(2E,7R,11R)-3,7,11,15-tetramethyl-hexadec-2-enoic acid | 22352-56-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (2E,7R,11R)-3,7,11,15-tetramethyl-hexadec-2-enoic acid
• 英文别名: (7R,11R)-3,7,11,15-tetramethyl-hexadec-2t-enoic acid；(7R,11R)-3,7,11,15-Tetramethyl-hexadec-2t-ensaeure；(7R,11R)-trans-Phytensaeure；Phytenoigsaeure；(2E,7R,11R)-phytenic acid；(E,7R,11R)-3,7,11,15-tetramethylhexadec-2-enoic acid
• CAS: 22352-56-3
• 化学式: C₂₀H₃₈O₂
• 分子量: 310.521
• InChiKey: WDWBNNBRPVEEOD-PFXVRADUSA-N

物化性质

• 沸点：
  417.1±14.0 °C(Predicted)
• 密度：
  0.892±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.4
• 重原子数：
  22
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2E,7R,11R)-3,7,11,15-tetramethyl-hexadec-2-enoic acid 生成 2,3-dihydrophytol
  参考文献：
  名称：

  Bessiere-Chretien,Y.; Marion,J.P., Bulletin de la Societe Chimique de France, 1970, p. 3013 - 3019

  摘要：

  DOI：
• 作为产物：
  描述：

  植物醇 在 manganese(IV) oxide 、 silver nitrate 作用下， 生成 (2E,7R,11R)-3,7,11,15-tetramethyl-hexadec-2-enoic acid
  参考文献：
  名称：

  Bessiere-Chretien,Y.; Marion,J.P., Bulletin de la Societe Chimique de France, 1970, p. 3013 - 3019

  摘要：

  DOI：

文献信息

• <i>N</i>-Acylvanillamides:  Development of an Expeditious Synthesis and Discovery of New Acyl Templates for Powerful Activation of the Vanilloid Receptor
  作者：Giovanni Appendino、Alberto Minassi、Aniello Schiano Morello、Luciano De Petrocellis、Vincenzo Di Marzo

  DOI：10.1021/jm020844o

  日期：2002.8.1

  A simple and general synthesis of vanillamides was developed and employed to screen acids from the fatty and isoprenoid pools for new acyl templates of biological relevance as capsaicin analogues. Potent activation of the human vanilloid receptor 1 (VR1) was observed for the vanillamides of certain polyfunctional acids from both pools, showing that the vanilloid activity of capsaicinoids can be. substantially improved by introducing polar groups and/or unsaturations on the acyl moiety. The activity of the unsaturated analogues was maintained or even increased by cyclopropAnation, while omega dimerization led to a substantial increase of activity. Because of the Wide structural diversity of the library of compounds screened, these observations could not be translated into a single framework of structure-activity relationships. Nevertheless, a series of new highly active leads was identified, validating the pharmacological potential of the unnatural combination of natural building blocks to provide new bioactive compounds.
• CANCER CELL GROWTH INHIBITING COMPOSITION AND PROCESSED FOOD
  申请人：HAGIHARA FARM PRODUCTION INSTITUTE CO., LTD.

  公开号：US20220135514A1

  公开（公告）日：2022-05-05

  Phytol contained in watermelon sprouts is known to have a cancer cell growth inhibiting effect. However, there is a problem that an amount of phytol to be taken for exhibiting cancer cell growth inhabition is large. A cancer cell growth inhibiting composition comprising at least one of compounds having a structure represented by Formula (1), Formula (2), Formula (6), Formula (7) or Formula (8), or a pharmaceutically acceptable salt thereof as main components has a higher cancer cell growth inhibiting effect than phytol.
• Bessiere-Chretien,Y.; Marion,J.P., Bulletin de la Societe Chimique de France, 1970, p. 3013 - 3019
  作者：Bessiere-Chretien,Y.、Marion,J.P.

  DOI：——

  日期：——