2-deoxyribose 1-phosphate | 18684-29-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-deoxyribose 1-phosphate
• 英文别名: deoxyribose 1-phosphate；2-Desoxy-β-D-ribofuranose-1-phosphat；2-deoxy-α-D-ribose-1-phosphate；2-deoxy-beta-D-ribose 1-phosphate；[(2S,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl] dihydrogen phosphate
• CAS: 18684-29-2
• 化学式: C₅H₁₁O₇P
• 分子量: 214.112
• InChiKey: KBDKAJNTYKVSEK-LMVFSUKVSA-N

物化性质

• 沸点：
  527.6±60.0 °C(Predicted)
• 密度：
  1.72±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  116
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2-deoxyribose 1-phosphate 、 <7-15N>guanide 在 nucleoside phosphorylase 、 三羟甲基氨基甲烷 作用下， 以 水 为溶剂， 反应 0.33h， 生成 <7-¹⁵N>2'-deoxyguanosine
  参考文献：
  名称：

  [7-15N]guanosine-labeled oligonucleotides as a nuclear magnetic resonance probe for protein-nucleic acid interaction in the major groove

  摘要：

  DOI：

  10.1021/ja00169a052
• 作为产物：
  描述：

  beta-胸苷 在 potassium phosphate 、 thymidine phosphorylase 、 三羟甲基氨基甲烷盐酸盐 作用下， 以 水 为溶剂， 反应 0.03h， 生成 2-deoxyribose 1-phosphate 、 胸腺嘧啶
  参考文献：
  名称：

  氟化酶偶联的碱基互换：[18F] -5'-脱氧-5'-氟尿苷的合成。

  摘要：

  DOI：

  10.1002/anie.200804040

文献信息

• Gene Therapy of Cancer: Activation of Nucleoside Prodrugs with<i>E. coli</i>Purine Nucleoside Phosphorylase
  作者：John A. Secrist、William B. Parker、Paula W. Allan、L. Lee Bennett、William R. Waud、Jackie W. Truss、Anita T. Fowler、John A. Montgomery、Steven E. Ealick、Alan H. Wells、G. Yancey Gillespie、V. K. Gadi、Eric J. Sorscher

  DOI：10.1080/15257779908041562

  日期：1999.4

  During the last few years, many gene therapy strategies have been developed for various disease targets. The development of anticancer gene therapy strategies to selectively generate cytotoxic nucleoside or nucleotide analogs is an attractive goal. One such approach involves the delivery of herpes simplex virus thymidine kinase followed by the acyclic nucleoside analog ganciclovir. We have developed another gene therapy methodology for the treatment of cancer that has several significant attributes. Specifically, our approach involves the delivery off. coli purine nucleoside phosphorylase, followed by treatment with a relatively non-toxic nucleoside prodrug that is cleaved by the enzyme to a toxic compound. This presentation describes the concept, details our search for suitable prodrugs, and summarizes the current biological data.
• Fluorinase-Coupled Base Swaps: Synthesis of [¹⁸F]-5′-Deoxy-5′-fluorouridines
  作者：Margit Winkler、Juozas Domarkas、Lutz F. Schweiger、David O'Hagan

  DOI：10.1002/anie.200804040

  日期：2008.12.15
• [7-15N]guanosine-labeled oligonucleotides as a nuclear magnetic resonance probe for protein-nucleic acid interaction in the major groove
  作者：Walter Massefski、Alfred Redfield、Ujjayini Das Sarma、Avijit Bannerji、Siddhartha Roy

  DOI：10.1021/ja00169a052

  日期：1990.6