(E)-D-glucose oxime | 57820-48-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (E)-D-glucose oxime
• 英文别名: (E)-D-Glucose-oxim；D-glucose (E)-oxime；(E)-Glucoseoxim；Glucosoxime；(2R,3R,4R,5S,6E)-6-hydroxyiminohexane-1,2,3,4,5-pentol
• CAS: 57820-48-1
• 化学式: C₆H₁₃NO₆
• 分子量: 195.172
• InChiKey: FQDOAQMGAIINEJ-LJVFLWCUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.2
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  134
• 氢给体数：
  6
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (E)-D-glucose oxime 、 水杨醛 生成
  参考文献：
  名称：

  RYAN, GARY;UTLEY, JAMES H. P.;JONES, HAYDN F., TETRAHEDRON LETT., 29,(1988) N 30, C. 3699-3702

  摘要：

  DOI：
• 作为产物：
  描述：

  1-Desoxy-N-hydroxy-β-D-glucopyranosylamin 在 丙酮酸 作用下， 以 氘代二甲亚砜 为溶剂， 反应 0.02h， 以70%的产率得到
  参考文献：
  名称：

  糖肟和α-酮酸与糖基酰胺和N-糖肽的化学选择性偶联

  摘要：

  未保护的糖羟胺和肟与α-酮酸的反应会导致Bode酮酸羟胺（KAHA）的脱羧缩合路径发生化学选择性的糖基酰胺形成。具有葡萄糖构型的糖肟立体选择性地形成β-连接的产物。该方法可用于收敛合成在酰基部分带有小标记，间隔基或肽的N-酰化糖和寡糖。

  DOI：

  10.1016/j.tetlet.2014.02.056

文献信息

• Nitrosation of Sugar Oximes: Preparation of 2-Glycosyl-1-hydroxydiazene-2-oxides
  作者：Jörg Brand、Thomas Huhn、Ulrich Groth、Johannes C. Jochims

  DOI：10.1002/chem.200500325

  日期：2006.1

  Oximes of glucose, xylose, lactose, fructose, and mannose have been prepared. Nitrosation of the oximes of glucose, xylose, and lactose with NaNO2/HCl afforded 2-(beta-glycopyranosyl)-1-hydroxydiazene-2-oxides, which were isolated as salts 13, 22, and 28. Nitrosation of fructose oxime 29 furnished fructose, whereas nitrosation of mannose oxime 30 with NaNO2/HCl afforded the 1-hydroxy-2-(beta-D-man

  已经制备了葡萄糖，木糖，乳糖，果糖和甘露糖的肟。用NaNO 2 / HCl亚硝化葡萄糖，木糖和乳糖的肟，得到2-（β-甘露糖基）-1-羟基二氮杂-2-氧化物，其被分离为盐13、22和28。提供了果糖肟的亚硝化29果糖，而甘露糖肟30用NaNO2 / HCl的亚硝化得到1-羟基-2-（β-D-甘露吡喃糖基）二氮杂-2-氧化物32，由此制得对茴香醚鎓盐31和钠盐33。然而，在CsOH或KOH的水溶液中用亚硝酸异戊酯亚硝化30，导致分别形成2-（α-D-甘露呋喃糖基）-1-羟基二氮杂2-氧化物盐34和35。2-（β-D-吡喃葡萄糖基）-1-羟基二氮杂-2-氧化物铵13的甲基化产生1-甲氧基化合物，将其苯甲酰化得到四-O-苯甲酸酯14a，通过X射线衍射分析证实其结构。由葡萄糖O-甲基肟15和16制备N-甲氧基-N-亚硝基-2,3,4,6-四-O-乙酰基-β-D-吡喃葡萄糖胺18。该化合物的结构通过
• Desoxy-nitrozucker. 13. Mitteilung. Herstellung ungeschützter und partiell geschützter 1-Desoxy-1-nitro-<scp>D</scp>-aldosen sowie Röntgenstrukturanalysen einiger ihrer Vertreter
  作者：Dieter Beer、Jost H. Bieri、Ingolf Macher、Roland Prewo、Andrea Vasella

  DOI：10.1002/hlca.19860690526

  日期：1986.7.30

  Preparation of Unprotected and Partially Protected 1-Deoxy-1-nitro-D-aldoses and Some Representative X-Ray Structure Analyses

  未保护和部分保护的1-脱氧-1-硝基-D-醛糖的制备及一些代表性的X射线结构分析
• The use of glucose oxime to increase glucose isomerase activity in bacterial cells
  申请人：——

  公开号：EP0118703A3

  公开（公告）日：1986-05-21

  Disclosed is a method of increasing the production of enzymes involved in the production of carbohydrate metabolism by bacterium of the species F. arborescens or E. coli. The method involves growing the bacterium on an aqueous nutrient medium containing glucose oxime.

  本发明公开了一种方法，可提高树枝状芽孢杆菌或大肠杆菌参与碳水化合物代谢生产的酶的产量。 该方法包括在含有葡萄糖肟的水营养培养基上培养细菌。
• Methods and Materials for Selective Boron Adsorption from Aqueous Solution
  申请人：ROH Il Juhn

  公开号：US20120037565A1

  公开（公告）日：2012-02-16

  A method for reducing a boron concentration in a boron-containing aqueous liquid involves administering micelle(s) for selective boron adsorption to the boron-containing aqueous liquid to produce boron-bonded micelle(s), wherein the micelle(s) comprise a reaction product of an N-substituted-glucamine and a glycidyl ether; passing the micelle-containing aqueous liquid through a membrane to separate the boron-bonded micelle(s) from the aqueous liquid; and recovering a permeate having a reduced boron concentration from the membrane. A material capable of selectively adsorbing boron from a boron-containing aqueous liquid contains at least one micelle having a hydrophobic tail and a head comprising a hydrophilic functional group having formula (I): R 1 —O-A  (I) R 1 represents a hydrocarbon group selected from the group consisting of substituted and unsubstituted aromatic, linear aliphatic, and branched aliphatic hydrocarbon groups and mixtures thereof, and A contains hydroxyl and amine groups.
• ALCOHOL-, DIOL-, AND CARBOHYDRATE-SUBSTITUTED INDENOISOQUINOLINES AS TOPOISOMERASE I INHIBITORS
  申请人：PURDUE RESEARCH FOUNDATION

  公开号：US20150148370A1

  公开（公告）日：2015-05-28

  The invention described herein pertains to substituted indenoisoquinoline compounds as described herein, wherein R A , R D , W, X and Y are defined herein, pharmaceutical compositions and formulations comprising the indenoisoquinoline compounds, their synthesis, and methods for their use in the treatment and/or prevention of cancer.