2-(Furan-2-yl)-2,2-dimethoxyethanol | 1442748-89-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(Furan-2-yl)-2,2-dimethoxyethanol
• 英文别名: 2-(furan-2-yl)-2,2-dimethoxyethanol
• CAS: 1442748-89-1
• 化学式: C₈H₁₂O₄
• 分子量: 172.181
• InChiKey: KMILMYVLZDSOHD-UHFFFAOYSA-N

物化性质

• 沸点：
  257.3±35.0 °C(Predicted)
• 密度：
  1.154±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  51.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(Furan-2-yl)-2,2-dimethoxyethanol 在 对甲苯磺酸 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 4.5h， 生成 2-呋喃基羟基甲基甲酮
  参考文献：
  名称：

  2-羟基苯乙酮的直接好氧氧化反应

  摘要：

  开发了2-羟基苯乙酮的无金属和无外部氧化剂的好氧氧化反应。该反应是基于有氧形成少量的2-酮醛的平衡量。邻苯二甲酰，喹喔啉，α-酮酰胺和烯烃可以直接从醇类以中等到良好的产率形成。DIPEA =二异丙基乙胺。

  DOI：

  10.1002/ejoc.201700909
• 作为产物：
  描述：

  2-乙酰基呋喃 、 甲醇 在 碘苯二乙酸 、 potassium hydroxide 作用下， 反应 3.0h， 生成 2-(Furan-2-yl)-2,2-dimethoxyethanol
  参考文献：
  名称：

  铱催化的动态动力学异构化：从Achmatowicz重排产物方便地合成碳水化合物

  摘要：

  发现了Achmatowicz重排产物的高度立体选择性的动态动力学异构化。这种新的内部氧化还原异构化为一系列天然糖的对映和非对映选择性合成提供了关键中间体的现成通道。从头合成的性质还使得能够制备两种对映异构体。

  DOI：

  10.1002/anie.201503151

文献信息

• Preparation and Application of α-Imino Ketones through One-Pot Tandem Reactions Based on Heyns Rearrangement
  作者：Ling Li、Shiqi Zhang、Xiongfei Deng、Guangxun Li、Zhuo Tang、Gang Zhao

  DOI：10.1021/acs.orglett.1c02390

  日期：2021.9.3

  α-Imino ketone is a useful building block for the preparation of α-amino ketones and α-amino alcohols. However, its preparation has been seldomly seen. Herein, a metal-free and operationally simple strategy has been developed to generate α-imino ketones with high regioselectivity. Meanwhile, the method allowed for the preparation of various N,O-ketals with high regioselectivities and diastereoselectivities

  α-亚氨基酮是制备 α-氨基酮和 α-氨基醇的有用构件。然而，很少有人看到它的准备工作。在此，已开发出一种无金属且操作简单的策略来生成具有高区域选择性的 α-亚氨基酮。同时，该方法允许通过一锅级联反应制备具有高区域选择性和非对映选择性的各种N,O-缩酮。
• 4-PREGENEN-11BETA-17-21-TRIOL-3,20-DIONE DERIVATIVES
  申请人：Allergan, Inc.

  公开号：US20130123223A1

  公开（公告）日：2013-05-16

  The present invention relates to novel 4-pregenen-11β-17-21-triol-3,20-dione derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals, as modulators of glucocorticoid or mineralocorticoid receptors. The invention relates specifically to the use of these compounds and their pharmaceutical compositions to treat disorders associated with glucocorticoid or mineralocorticoid receptor modulation.

  本发明涉及新型的4-孕烷-11β-17-21-三醇-3,20-二酮衍生物，其制备方法，包含它们的制药组合物以及它们作为药物的用途，作为糖皮质激素或醛固酮受体调节剂。本发明具体涉及这些化合物及其制药组合物用于治疗与糖皮质激素或醛固酮受体调节相关的疾病。
• Palladium-catalyzed ring-opening [5+2] annulation of vinylethylene carbonates (VECs) and C5-substituted Meldrum's acids: rapid synthesis of 7-membered lactones
  作者：Fei Li、Xin Chen、Ben-Qing Huang、Hua-Dong Xu、Chi-Fan Zhu、Mei-Hua Shen

  DOI：10.1039/d3cc05819k

  日期：——

  A novel approach for the synthesis of unsaturated 7-membered lactones by Pd-catalyzed [5+2] dipolar cycloaddition of vinylethylene carbonates (VECs) and C5-substituted Meldrum's acid derivatives has been developed. Various Meldrum's acid derivatives worked well in this reaction under mild reaction conditions. A variety of 7-membered lactones can be accessed in a facile manner in moderate to good yields

  开发了一种通过 Pd 催化乙烯基碳酸亚乙酯 (VEC) 和 C5 取代的 Meldrum 酸衍生物的 [5+2] 偶极环加成合成不饱和 7 元内酯的新方法。在温和的反应条件下，各种Meldrum酸衍生物在此反应中表现良好。通过使用容易制备的Meldrum酸衍生物，可以以中等至良好的产率以简便的方式获得各种7元内酯。
• Oxidative Coupling of Terminal Alkyne with α-Hydroxy Ketone: An Expedient Approach toward Ynediones
  作者：Zeguang Zhang、Xuefeng Jiang

  DOI：10.1021/ol502298a

  日期：2014.9.5

  An efficient and mild copper-catalyzed one-pot approach toward ynediones has been established. A variety of ynediones were constructed directly through oxidative coupling of alkyne with alpha-hydroxy ketone. Oxygen-oxidizing and neutral conditions in one-pot for a wide range of substrates including natural product derivatives make this transformation highly efficient and practical. On the basis of control experiments, in situ IR measurements, and isotopic labeling experiments, a plausible mechanism involving intermediate phenylglyoxal was drawn. Applications by synthesis of various heterocycles were also investigated.
• Investigation and Application of Amphoteric α-Amino Aldehyde: An in Situ Generated Species Based on Heyns Rearrangement
  作者：Guangxun Li、Ling Tang、Hongxin Liu、Yingwei Wang、Gang Zhao、Zhuo Tang

  DOI：10.1021/acs.orglett.6b02133

  日期：2016.9.16

  In situ generation of the reactive amphoteric a amino aldehyde with simple alpha-hydroxy ketones and phenyl amine-via Heyns rearrangement was proven to be feasible. Metal-free domino reactions based on this reactive intermediate were effectively used to afford important N-heterocycles including polysubstituted pyrroles, indoles, and quinoxalines conveniently. A simple starting material, water as the only byproduct, and diversity of the useful products will make this method greatly attractive for pharmaceutics.