6-bromo-3-(3-(3-nitrophenyl)acryloyl)-2H-chromen-2-one | 202828-03-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 6-bromo-3-(3-(3-nitrophenyl)acryloyl)-2H-chromen-2-one
• 英文别名: 6-Bromo-3-[3-(3-nitrophenyl)prop-2-enoyl]chromen-2-one
• CAS: 202828-03-3
• 化学式: C₁₈H₁₀BrNO₅
• mdl: MFCD00197434
• 分子量: 400.185
• InChiKey: DAXBKKRKMQZGHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  89.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  copper(II) nitrate trihydrate 、 6-bromo-3-(3-(3-nitrophenyl)acryloyl)-2H-chromen-2-one 、 环丙沙星 、 水 在 ammonium hydroxide 作用下， 以 乙醇 为溶剂， 反应 5.0h， 以72%的产率得到
  参考文献：
  名称：

  Synthesis, Thermal, and Biological Studies of Newly Synthesized Cu(II) Complexes With Ciprofloxacin Based on Bromo-Coumarins Derivatives

  摘要：

  The authors describe synthesis, characterization, and biological evaluation of Cu(II) complexes. Characterization of ligands has been carried out by elemental analysis, melting point, mass spectra, (H-1 & C-13) NMR, and FT-IR, while structure of metal complexes was confirmed by electronic spectra and FAB-mass spectral studies. Spectral studies confirm ligands is mono functional bidentate and octahedral environment around metal ions. Thermal behavior of Cu(II) complexes were investigated by means of TGA and magnetic measurements. The kinetic parameters are reported using the Freeman-Carroll method. Complexes were found significant potent antimicrobial and antioxidant activities compared to parent ligands employed for complexation. Supplemental materials are available for this article. Go to the publisher's online edition of Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry to view the supplemental file.

  DOI：

  10.1080/15533174.2012.754763
• 作为产物：
  描述：

  5-溴水杨醛 在 哌啶 、 吡啶 作用下， 反应 0.83h， 生成 6-bromo-3-(3-(3-nitrophenyl)acryloyl)-2H-chromen-2-one
  参考文献：
  名称：

  Synthesis, Thermal, and Biological Studies of Newly Synthesized Cu(II) Complexes With Ciprofloxacin Based on Bromo-Coumarins Derivatives

  摘要：

  The authors describe synthesis, characterization, and biological evaluation of Cu(II) complexes. Characterization of ligands has been carried out by elemental analysis, melting point, mass spectra, (H-1 & C-13) NMR, and FT-IR, while structure of metal complexes was confirmed by electronic spectra and FAB-mass spectral studies. Spectral studies confirm ligands is mono functional bidentate and octahedral environment around metal ions. Thermal behavior of Cu(II) complexes were investigated by means of TGA and magnetic measurements. The kinetic parameters are reported using the Freeman-Carroll method. Complexes were found significant potent antimicrobial and antioxidant activities compared to parent ligands employed for complexation. Supplemental materials are available for this article. Go to the publisher's online edition of Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry to view the supplemental file.

  DOI：

  10.1080/15533174.2012.754763

文献信息

• Synthesis, Thermal, and Biological Studies of Newly Synthesized Cu(II) Complexes With Ciprofloxacin Based on Bromo-Coumarins Derivatives
  作者：Ketan S. Patel、Jiten C. Patel、Hitesh R. Dholariya、Kanuprasad D. Patel

  DOI：10.1080/15533174.2012.754763

  日期：2013.9.14

  The authors describe synthesis, characterization, and biological evaluation of Cu(II) complexes. Characterization of ligands has been carried out by elemental analysis, melting point, mass spectra, (H-1 & C-13) NMR, and FT-IR, while structure of metal complexes was confirmed by electronic spectra and FAB-mass spectral studies. Spectral studies confirm ligands is mono functional bidentate and octahedral environment around metal ions. Thermal behavior of Cu(II) complexes were investigated by means of TGA and magnetic measurements. The kinetic parameters are reported using the Freeman-Carroll method. Complexes were found significant potent antimicrobial and antioxidant activities compared to parent ligands employed for complexation. Supplemental materials are available for this article. Go to the publisher's online edition of Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry to view the supplemental file.