2-iodoethylamine | 52689-15-3

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机碘化物
• 英文名称: 2-iodoethylamine
• 英文别名: 1-Amino-2-jod-aethan；2-Jod-aethylamin；β-Jod-aethylamin；2-Iodoethan-1-amine；2-iodoethanamine
• CAS: 52689-15-3
• 化学式: C₂H₆IN
• mdl: MFCD06212590
• 分子量: 170.981
• InChiKey: DIOZLZOUTWUWIQ-UHFFFAOYSA-N

物化性质

• 沸点：
  158.0±23.0 °C(Predicted)
• 密度：
  2.034±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  4
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 储存条件：
  2-8°C

反应信息

• 作为反应物：
  描述：

  2-iodoethylamine 、 氯甲酸丁酯 在 sodium hydroxide 作用下， 生成 (2-iodo-ethyl)-carbamic acid butyl ester
  参考文献：
  名称：

  2-OXAZOLIDONES: SYNTHESIS FROM N-CARBALKOXY-β-HALOALKYLAMINES¹

  摘要：

  DOI：

  10.1021/jo01151a025
• 作为产物：
  描述：

  C.I.酸性橙108 在 水 、 氢碘酸 作用下， 生成 2-iodoethylamine
  参考文献：
  名称：

  2-OXAZOLIDONES: SYNTHESIS FROM N-CARBALKOXY-β-HALOALKYLAMINES¹

  摘要：

  DOI：

  10.1021/jo01151a025

文献信息

• [EN] LIPID-BASED PLATINUM-N-HETEROCYCLIC CARBENE COMPOUNDS AND NANOPARTICLES<br/>[FR] COMPOSÉS ET NANOPARTICULES DE PLATINE-CARBÈNE N-HÉTÉROCYCLIQUE À BASE DE LIPIDES
  申请人：INVICTUS ONCOLOGY PVT LTD

  公开号：WO2014199352A3

  公开（公告）日：2015-04-16
• Synthesis and SAR of 2,3-diarylpyrrole inhibitors of parasite cGMP-dependent protein kinase as novel anticoccidial agents
  作者：Tesfaye Biftu、Dennis Feng、Mitree Ponpipom、Narindar Girotra、Gui-Bai Liang、Xiaoxia Qian、Robert Bugianesi、Joseph Simeone、Linda Chang、Anne Gurnett、Paul Liberator、Paula Dulski、Penny Sue Leavitt、Tami Crumley、Andrew Misura、Terence Murphy、Sandra Rattray、Samantha Samaras、Tamas Tamas、John Mathew、Christine Brown、Don Thompson、Dennis Schmatz、Michael Fisher、Matthew Wyvratt

  DOI：10.1016/j.bmcl.2005.04.060

  日期：2005.7

  Several analogs of 2,3-diaryl pyrroles were synthesized and evaluated as inhibitors of Eimeria tenella cGMP-dependent protein kinase and in. in vivo anticoccidial assays. A 4-fluorophenyl group enhances both in vitro and in Vivo activities. The most potent analogs are the-5-(N-methyl, N-ethyl, and N-methylazetidine methyl) piperidyl derivatives 12, 23, and 34. These compounds have a broad spectrum of activity. Based on the in vivo efficacy and cost of synthesis, the N-ethyl analog 23 was chosen as a novel anticoccidial agent for a field trial. (c) 2005 Elsevier Ltd. All rights reserved.
• Melanocortin subtype-4 receptor agonists containing a piperazine core with substituted aryl sulfonamides
  作者：Christopher Fotsch、Nianhe Han、Premilla Arasasingham、Yunxin Bo、Michelle Carmouche、Ning Chen、James Davis、Martin H. Goldberg、Clarence Hale、Feng-Yin Hsieh、Michael G. Kelly、Qingyian Liu、Mark H. Norman、Duncan M. Smith、Markian Stec、Nuria Tamayo、Ning Xi、Shimin Xu、Anthony W. Bannon、James W. Baumgartner

  DOI：10.1016/j.bmcl.2005.01.060

  日期：2005.3

  The biological activity for a set of melanocortin-4 receptor (MC4R) agonists containing a piperazine core with an ortho-substituted aryl sulfonamide is described. Compounds from this set had binding and functional activities at MC4R less than 30 nM. The most selective compound in this series was > 25,000-fold more potent at MC4R than MC3R, and 490-fold more potent at MC4R than MC5R. This compound also reduced food intake after oral dosing at 25, 50, and 100 mg kg(-1) in fasted mice. (c) 2005 Elsevier Ltd. All rights reserved.
• Synthesis of N-(2-[18F]fluoroethyl)-N′-methylthiourea: a hydrogen peroxide scavenger
  作者：C. Gilissen、G. Bormans、T. de Groot、A. Verbruggen

  DOI：10.1002/(sici)1099-1344(199806)41:6<491::aid-jlcr102>3.0.co;2-9

  日期：1998.6

  N-(2-[F-18]fluoroethyl)-N'-methylthiourea ([F-18]FEMTU), a fluorine-18 labelled derivative of the hydrogen peroxide scavenger dimethylthiourea (DMTU), has been synthesized by reaction of 2-[F-18]fluoroethylamine with methylisothiocyanate. 2-[F-18]Fluoroethylamine was obtained in modest radiochemical yields (39+/-6%, mean+/-sd, n=5, decay corrected) by nucleophilic substitution with [F-18]fluoride on N-[2(p-toluenesulfonyloxy)ethyl] phthalimide followed by deprotection with hydrazine and distillation.The distilled 2-[F-18]fluoroethylamine was trapped in CH2Cl2 and reacted with methylisothiocyanate to yield [F-18]FEMTU that was purified by reversed phase HPLC. The total synthesis takes 150 min and provides [F-18]FEMTU with a specific activity of 3.3+0.5 GBq/mu mol (mean+/-sd, n=3) at end of synthesis, with an overall decay corrected radiochemical yield of 25+/-8% (mean+/-sd, n=5).
• 2-OXAZOLIDONES: SYNTHESIS FROM N-CARBALKOXY-β-HALOALKYLAMINES¹
  作者：EPHRAIM KATCHALSKI、DOV BEN ISHAI

  DOI：10.1021/jo01151a025

  日期：1950.9