6,7-dihydropyrido[3,2,1-ij]quinolin-1(5H)-one | 1399859-04-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6,7-dihydropyrido[3,2,1-ij]quinolin-1(5H)-one
• 英文别名: 1-Azatricyclo[7.3.1.05,13]trideca-2,5,7,9(13)-tetraen-4-one
• CAS: 1399859-04-1
• 化学式: C₁₂H₁₁NO
• 分子量: 185.225
• InChiKey: RKCDIJOQOWHUFN-UHFFFAOYSA-N

物化性质

• 沸点：
  332.0±42.0 °C(Predicted)
• 密度：
  1.25±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-(1,2,3,4-tetrahydroquinolin-8-yl)propan-1-one 在 吗啉 、 bis(1,5-cyclooctadiene)nickel (0) 、 potassium phosphate 、 三甲基膦 作用下， 以 N,N-二甲基甲酰胺 、 氯苯 为溶剂， 反应 48.0h， 以83%的产率得到6,7-dihydropyrido[3,2,1-ij]quinolin-1(5H)-one
  参考文献：
  名称：

  Synthesis of 4-Quinolones through Nickel-Catalyzed Intramolecular Amination on the β-Carbon of o-(N-Alkylamino)propiophenones

  摘要：

  o-(N-Alkylamino)propiophenones are converted into 4-quinolones in the presence of chlorobenzene, potassium phosphate, morpholine, and nickel(0) catalyst. The reaction proceeds through the nickel-catalyzed formation of beta-enaminones from o-(N-alkylamino)propiophenones and morpholine, followed by the intramolecular transamination.

  DOI：

  10.1055/s-0031-1291146

文献信息

• Novel 14 and 15 Membered Ring Compounds
  申请人：Alihodzic Sulejman

  公开号：US20070293472A1

  公开（公告）日：2007-12-20

  The present invention relates to 14- or 15-membered macrolides substituted at the 4″ position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis of systemic or topical microbial infections in a human or animal body.

  本发明涉及在式（I）的4”位取代的14或15元大环内酯及其药学上可接受的衍生物，以及它们的制备方法和在人或动物体内治疗或预防系统性或局部微生物感染的用途。
• Novel 14 and 15 membrered ring compounds
  申请人：Alihodzic Sulejman

  公开号：US20070185117A1

  公开（公告）日：2007-08-09

  The present invention relates to 14- or 15-membered macrolides substituted at the 4″ position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis of systemic or topical microbial infections in a human or animal body.

  本发明涉及在公式(I)的4″位置被取代的14或15元环大环内酯及其药学上可接受的衍生物，以及它们的制备过程和在人或动物体内治疗或预防系统性或局部微生物感染中的用途。
• Neue Chlormethylchinolin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung
  申请人：ALKALOIDA VEGYéSZETI GYáR

  公开号：EP0113432B1

  公开（公告）日：1993-03-17
• ANIMAL MODELS, SCREENING METHODS, AND TREATMENT METHODS FOR INTRAOCULAR DISEASES OR DISORDERS
  申请人：ZHUHAI QIWEI BIO-TECHNOLOGY LTD.

  公开号：US20220015338A1

  公开（公告）日：2022-01-20

  Provided herein are screening methods and animal models related to intraocular diseases such as age-related macular degeneration (AMD), for example, for identifying candidate therapeutics for treating or preventing eye diseases, such as AMD. Also provided herein are compounds/compositions that are useful for killing or inhibiting the growth of a microorganism, such as Bacillus megaterium . Further provided herein are methods of using the compounds/compositions for treating infections with a microorganism, such as Bacillus megaterium and for treating or preventing diseases or disorders associated with such infections, such as AMD.
• METHOD OF TREATING AGE-RELATED MACULAR DEGENERATION
  申请人：ZHUHAI QiWEl BIO-TECHNOLOGY LTD.

  公开号：US20220016146A1

  公开（公告）日：2022-01-20

  Provided herein are compounds/compositions that are useful for killing or inhibiting the growth of a microorganism, such as Bacillus megaterium . Also provided herein are methods of using the compounds/compositions for treating infections with a microorganism, such as Bacillus megaterium and for treating or preventing diseases or disorders associated with such infections, such as AMD.