D-Phenylalaninamide, N-acetyl-D-tyrosyl-D-arginyl- | 1809784-29-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: D-Phenylalaninamide, N-acetyl-D-tyrosyl-D-arginyl-
• 英文别名: (2R)-2-[[(2R)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-N-[(2R)-1-amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)pentanamide
• CAS: 1809784-29-9
• 化学式: C₂₆H₃₅N₇O₅
• 分子量: 525.6
• InChiKey: AOUZPXZGMZUQQS-YPAWHYETSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  38
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  215
• 氢给体数：
  7
• 氢受体数：
  6

文献信息

• GADD45BETA TARGETING AGENTS
  申请人：Imperial Innovations Limited

  公开号：US20150368294A1

  公开（公告）日：2015-12-24

  Compounds based around tetrapeptide, tripeptide and dipeptide moeties and corresponding peptiod moeties. Related methods and pharmaceutical compositions for use in treatment of cancer, inflammatory diseases, and other disorders.

  以四肽、三肽和二肽为基础的化合物，以及相应的肽类基元。相关方法和药物组合物，用于治疗癌症、炎症性疾病和其他疾病。
• GADD45BETA/MKK7 INHIBITOR FOR THE TREATMENT OF A RESISTANT HAEMATOLOGICAL MALIGNANCY
  申请人：IMPERIAL INNOVATIONS LIMITED

  公开号：US20170240592A1

  公开（公告）日：2017-08-24

  A Gadd45β/MKK7 inhibitor for use in a method of treating a resistant haematological malignancy, combinations of said inhibitor with a further anti-cancer agent and related methods of use.
• METHODS OF DIFFERENTIATING STEM CELLS INTO ENDODERM
  申请人：MEMORIAL SLOAN-KETTERING CANCER CENTER

  公开号：US20190224251A1

  公开（公告）日：2019-07-25

  The present invention relates to methods and compositions for enhancing the differentiation of stem cells into endodermal cells by inhibiting JNK signaling. The present invention is also directed to methods of treating endodermal disorders in a subject, comprising administering inhibitors of JNK signaling to the subject.
• US9518083B2
  申请人：——

  公开号：US9518083B2

  公开（公告）日：2016-12-13