4-(4-Fluorophenyl)-1,2-diphenylbut-2-ene-1,4-dione | 883048-21-3

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物
• 英文名称: 4-(4-Fluorophenyl)-1,2-diphenylbut-2-ene-1,4-dione
• CAS: 883048-21-3
• 化学式: C₂₂H₁₅FO₂
• 分子量: 330.358
• InChiKey: UJFNFBRQUPJYTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(4-Fluorophenyl)-1,2-diphenylbut-2-ene-1,4-dione 在 甲醇 、 三氯硅烷 、 三苯基氧化膦 作用下， 以 1,2-二氯乙烷 为溶剂， 生成 5-(4-fluorophenyl)-2,3-diphenylfuran
  参考文献：
  名称：

  Successively Recycle Waste as Catalyst: A One-Pot Wittig/1,4-Reduction/Paal–Knorr Sequence for Modular Synthesis of Substituted Furans

  摘要：

  A one-pot tandem Wittig/conjugate reduction/PaalKnorr reaction is reported for the synthesis of di- or trisubstituted furans. This novel sequence first demonstrates the possibility of successively recycling waste from upstream steps to catalyze downstream reactions.

  DOI：

  10.1021/acs.orglett.5b00442
• 作为产物：
  描述：

  1-(4-fluorophenyl)-2-(triphenyl-λ⁵phosphanylidene)ethanone 、 联苯甲酰 以 甲苯 为溶剂， 反应 36.0h， 生成 4-(4-Fluorophenyl)-1,2-diphenylbut-2-ene-1,4-dione
  参考文献：
  名称：

  Successively Recycle Waste as Catalyst: A One-Pot Wittig/1,4-Reduction/Paal–Knorr Sequence for Modular Synthesis of Substituted Furans

  摘要：

  A one-pot tandem Wittig/conjugate reduction/PaalKnorr reaction is reported for the synthesis of di- or trisubstituted furans. This novel sequence first demonstrates the possibility of successively recycling waste from upstream steps to catalyze downstream reactions.

  DOI：

  10.1021/acs.orglett.5b00442

文献信息

• One-Pot Synthesis of (Guaiazulen-1-yl)furan Derivatives from Guaiazulene and 1,4-Diaryl-2-butene-1,4-diones
  作者：Dao-Lin Wang、Jiao Xu、Jia-Yi Yu、Zhe Dong

  DOI：10.3987/com-13-12690

  日期：——

  A facile, convenient, efficient, and high yielding synthesis of 3-(guaiazulen-1-yl)furan derivatives (3) has been developed by the condensation of guaiazulene (1) with 1,4-diaryl-2-butene-1, 4-diones (2) as nucleophiles in the presence of p-toluenesulfonic acid as the catalyst.
• Successively Recycle Waste as Catalyst: A One-Pot Wittig/1,4-Reduction/Paal–Knorr Sequence for Modular Synthesis of Substituted Furans
  作者：Long Chen、Yi Du、Xing-Ping Zeng、Tao-Da Shi、Feng Zhou、Jian Zhou

  DOI：10.1021/acs.orglett.5b00442

  日期：2015.3.20

  A one-pot tandem Wittig/conjugate reduction/PaalKnorr reaction is reported for the synthesis of di- or trisubstituted furans. This novel sequence first demonstrates the possibility of successively recycling waste from upstream steps to catalyze downstream reactions.