ethyl 4-(guaiazulen-1-yl)-2-phenyl-5-(2-thienyl)furan-3-carboxylate | 1447465-58-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: ethyl 4-(guaiazulen-1-yl)-2-phenyl-5-(2-thienyl)furan-3-carboxylate
• 英文别名: Ethyl 4-(3,8-dimethyl-5-propan-2-ylazulen-1-yl)-2-phenyl-5-thiophen-2-ylfuran-3-carboxylate；ethyl 4-(3,8-dimethyl-5-propan-2-ylazulen-1-yl)-2-phenyl-5-thiophen-2-ylfuran-3-carboxylate
• CAS: 1447465-58-8
• 化学式: C₃₂H₃₀O₃S
• 分子量: 494.654
• InChiKey: FYUCJYNVCCUNKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.7
• 重原子数：
  36
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  67.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  愈创奥 、 在 对甲苯磺酸 作用下， 以 二氯甲烷 为溶剂， 反应 8.0h， 以83%的产率得到ethyl 4-(guaiazulen-1-yl)-2-phenyl-5-(2-thienyl)furan-3-carboxylate
  参考文献：
  名称：

  One-Pot Synthesis of (Guaiazulen-1-yl)furan Derivatives from Guaiazulene and 1,4-Diaryl-2-butene-1,4-diones

  摘要：

  A facile, convenient, efficient, and high yielding synthesis of 3-(guaiazulen-1-yl)furan derivatives (3) has been developed by the condensation of guaiazulene (1) with 1,4-diaryl-2-butene-1, 4-diones (2) as nucleophiles in the presence of p-toluenesulfonic acid as the catalyst.

  DOI：

  10.3987/com-13-12690

文献信息

• One-Pot Synthesis of (Guaiazulen-1-yl)furan Derivatives from Guaiazulene and 1,4-Diaryl-2-butene-1,4-diones
  作者：Dao-Lin Wang、Jiao Xu、Jia-Yi Yu、Zhe Dong

  DOI：10.3987/com-13-12690

  日期：——

  A facile, convenient, efficient, and high yielding synthesis of 3-(guaiazulen-1-yl)furan derivatives (3) has been developed by the condensation of guaiazulene (1) with 1,4-diaryl-2-butene-1, 4-diones (2) as nucleophiles in the presence of p-toluenesulfonic acid as the catalyst.