126F-004 | 848701-25-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 126F-004
• 英文别名: N-[(2S,3R,4R,5R,6R)-5-hydroxy-6-(hydroxymethyl)-2-[2-[2-[2-[2-[2-[2-(5-sulfanylpentoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-4-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-3-yl]acetamide
• CAS: 848701-25-7
• 化学式: C₃₁H₅₉NO₁₇S
• 分子量: 749.872
• InChiKey: QFSRXYNXNKVOBE-JGQJXZNDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.2
• 重原子数：
  50
• 可旋转键数：
  29
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.97
• 拓扑面积：
  244
• 氢给体数：
  8
• 氢受体数：
  18

反应信息

• 作为反应物：
  描述：

  126F-004 生成 126F-062
  参考文献：
  名称：

  [EN] CARBOHYDRATE ANTIGEN-NANOPARTICLE CONJUGATES AND USES THEREOF AS ANTIMETASTATIC AGENTS IN TREATING CANCER
  [FR] CONJUGUES DE NANOPARTICULES-ANTIGENES CARBOHYDRATE ET UTILISATION COMME AGENTS ANTI-METASTATIQUES DANS LE TRAITEMENT DU CANCER

  摘要：

  公开号：

  WO2005046722A3
• 作为产物：
  描述：

  六甘醇 在 甲醇 、 sodium hydroxide 、 偶氮二异丁腈 、 三氟甲磺酸三甲基硅酯 、 sodium methylate 、 溶剂黄146 、 乙酰氯 、 锌 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 反应 31.0h， 生成 126F-004
  参考文献：
  名称：

  Synthesis of gold nanoparticles bearing the Thomsen–Friedenreich disaccharide: a new multivalent presentation of an important tumor antigen

  摘要：

  Herein we describe the synthesis gold nanoshells encapsulated with up to 90 units of the Thomsen-Friedenreich (TF) tumor-associated carbohydrate antigen (TACA) disaccharide (Galbeta1-3GaINAc-alpha-O-Ser/Thr) as well as the assembly of a suitably linked designer glycopeptide as a precursor to similar multivalent presentations on gold. The TF-coated nanoparticles are highly stable, water soluble, and easily handled. Improvements in the linker technology used to attach the disaccharide to the particles led to a robust multivalent platform for the presentation of this important carbohydrate. The antigen retains all recognition characteristics while displayed on this template as shown by several in vitro assays. This area of research could lead to the development of novel therapeutic agents that inhibit protein-carbohydrate interactions. Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetasy.2004.12.003

文献信息

• Synthesis of gold nanoparticles bearing the Thomsen–Friedenreich disaccharide: a new multivalent presentation of an important tumor antigen
  作者：Sergei A. Svarovsky、Zoltan Szekely、Joseph J. Barchi

  DOI：10.1016/j.tetasy.2004.12.003

  日期：2005.1

  Herein we describe the synthesis gold nanoshells encapsulated with up to 90 units of the Thomsen-Friedenreich (TF) tumor-associated carbohydrate antigen (TACA) disaccharide (Galbeta1-3GaINAc-alpha-O-Ser/Thr) as well as the assembly of a suitably linked designer glycopeptide as a precursor to similar multivalent presentations on gold. The TF-coated nanoparticles are highly stable, water soluble, and easily handled. Improvements in the linker technology used to attach the disaccharide to the particles led to a robust multivalent platform for the presentation of this important carbohydrate. The antigen retains all recognition characteristics while displayed on this template as shown by several in vitro assays. This area of research could lead to the development of novel therapeutic agents that inhibit protein-carbohydrate interactions. Published by Elsevier Ltd.
• [EN] CARBOHYDRATE ANTIGEN-NANOPARTICLE CONJUGATES AND USES THEREOF AS ANTIMETASTATIC AGENTS IN TREATING CANCER<br/>[FR] CONJUGUES DE NANOPARTICULES-ANTIGENES CARBOHYDRATE ET UTILISATION COMME AGENTS ANTI-METASTATIQUES DANS LE TRAITEMENT DU CANCER
  申请人：US GOV HEALTH & HUMAN SERV

  公开号：WO2005046722A3

  公开（公告）日：2005-07-21