3-bromo-2-phenoxypyridine | 1167991-22-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-bromo-2-phenoxypyridine
• CAS: 1167991-22-1
• 化学式: C₁₁H₈BrNO
• mdl: MFCD14584706
• 分子量: 250.095
• InChiKey: UAGNHWZDNVZCTN-UHFFFAOYSA-N

物化性质

• 沸点：
  295.9±25.0 °C(Predicted)
• 密度：
  1.476±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-bromo-2-phenoxypyridine 、 3.6-二氢-2H-吡啶-1-叔丁氧羰基-4-硼酸新戊二醇酯 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride cesium fluoride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以53%的产率得到tert-butyl 4-(2-phenoxypyridin-3-yl)-5,6-dihydropyridine-1(2H)-carboxylate
  参考文献：
  名称：

  [EN] PHENOXY-PYRIDYL DERIVATIVES
  [FR] DÉRIVÉS PHÉNOXY-PYRIDYLÉS

  摘要：

  披露了化合物及化合物的药物可接受盐，其中化合物具有本说明书中定义的式(I)的结构。还披露了相应的药物组合物、治疗方法、合成方法和中间体。

  公开号：

  WO2009081259A1
• 作为产物：
  描述：

  3-溴-2-氯吡啶 、 苯酚 在 sodium carbonate 作用下， 以 二甲基亚砜 为溶剂， 反应 24.0h， 以34%的产率得到3-bromo-2-phenoxypyridine
  参考文献：
  名称：

  Base-regulated tunable synthesis of pyridobenzoxazepinones and pyridobenzoxazines

  摘要：

  已开发出一种基础调控的一锅法协议，用于可调合成吡啶苯并噁唑酮和吡啶苯并噁唑胺。吡啶苯并噁唑酮和吡啶苯并噁唑胺以良好的产率选择性地产生。

  DOI：

  10.1039/c5cy00798d

文献信息

• Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agonists
  作者：Amy B. Dounay、Nancy S. Barta、Brian M. Campbell、Corey Coleman、Elizabeth M. Collantes、Lynne Denny、Satavisha Dutta、David L. Gray、Dongfeng Hou、Rathna Iyer、Samarendra N. Maiti、Daniel F. Ortwine、Al Probert、Nancy C. Stratman、Rajendra Subedi、Tammy Whisman、Wenjian Xu、Kim Zoski

  DOI：10.1016/j.bmcl.2009.12.023

  日期：2010.2

  Preclinical studies suggest that compounds with dual norepinephrine reuptake inhibitor (NRI) and 5-HT1A partial agonist properties may provide an important new therapeutic approach to ADHD, depression, and anxiety. Reported herein is the discovery of a novel chemical series with a favorable NRI and 5-HT1A partial agonist pharmacological pro. le as well as excellent selectivity for the norepinephrine transporter over the dopamine transporter. (C) 2009 Elsevier Ltd. All rights reserved.
• Copper-catalyzed highly regioselective 2-aryloxylation of 2,x-dihalopyridines
  作者：Qizhong Zhou、Bin Zhang、Tieqi Du、Haining Gu、Yuyuan Ye、Huajiang Jiang、Rener Chen

  DOI：10.1016/j.tet.2012.10.025

  日期：2013.1

  2,x-Dihalopyridines reacted with phenols catalyzed by CuI/TMEDA in the presence of Cs2CO3 in DMSO at 110 degrees C under nitrogen atmosphere for 24 h to afford 2-aryloxypyridines in good to high yields except p-nitrophenol. To expand this methodology, a vanilloid receptor ligand used in treatments was prepared in good yield. This method has potential utility in the synthesis of pharmaceuticals, agrochemicals and even natural products. (C) 2012 Elsevier Ltd. All rights reserved.
• [EN] COMPOUNDS AND COMPOSITIONS THAT INHIBIT PIKFYVE<br/>[FR] COMPOSÉS ET COMPOSITIONS QUI INHIBENT PIKFYVE
  申请人：[en]KINETA, INC.

  公开号：WO2023107557A1

  公开（公告）日：2023-06-15

  Pyrazolo[1,5-a]pyrimidines are disclosed. These compounds may be useful in the treatment of neurological disorder, including frontotemporal dementia, chronic traumatic encephalopathy, Alzheimer's disease, limbic-predominant age-related TDP-43 encephalopathy, or frontotemporal lobar degeneration. Further, the invention features a method of inhibiting toxicity in a cell related to a protein TDP-43 or C9orf72. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.
• [EN] PHENOXY-PYRIDYL DERIVATIVES<br/>[FR] DÉRIVÉS PHÉNOXY-PYRIDYLÉS
  申请人：PFIZER

  公开号：WO2009081259A1

  公开（公告）日：2009-07-02

  Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I), as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

  披露了化合物及化合物的药物可接受盐，其中化合物具有本说明书中定义的式(I)的结构。还披露了相应的药物组合物、治疗方法、合成方法和中间体。
• Base-regulated tunable synthesis of pyridobenzoxazepinones and pyridobenzoxazines
  作者：Chaoren Shen、Xiao-Feng Wu

  DOI：10.1039/c5cy00798d

  日期：——

  A base-regulated one-pot protocol for the tunable synthesis of pyridobenzoxazepinones and pyridobenzoxazines has been developed. Pyridobenzoxazepinones and pyridobenzoxazines were produced in good yields selectively.

  已开发出一种基础调控的一锅法协议，用于可调合成吡啶苯并噁唑酮和吡啶苯并噁唑胺。吡啶苯并噁唑酮和吡啶苯并噁唑胺以良好的产率选择性地产生。