4'-[3-(di-n-butylamino)propoxy]acetophenone | 1257220-36-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4'-[3-(di-n-butylamino)propoxy]acetophenone
• 英文别名: 4-[3-(dibutylamino)-propoxy]-acetophenone；1-(4-(3-(dibutylamino)propoxy)phenyl)ethanone；1-[4-[3-(dibutylamino)propoxy]phenyl]ethanone
• CAS: 1257220-36-2
• 化学式: C₁₉H₃₁NO₂
• 分子量: 305.461
• InChiKey: XHEHJGBRYWSWGQ-UHFFFAOYSA-N

物化性质

• 沸点：
  420.2±25.0 °C(Predicted)
• 密度：
  0.962±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  22
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4'-[3-(di-n-butylamino)propoxy]acetophenone 在 trityl perchlorate 、 sodium hydride 、 三乙胺 作用下， 以 二氯甲烷 、 甲苯 、 mineral oil 为溶剂， 反应 2.0h， 生成 决奈达隆
  参考文献：
  名称：

  [EN] PROCESS FOR THE PREPARATION OF 3-AROYL-5-AMINOBENZOFURAN DERIVATIVES
  [FR] PROCÉDÉ POUR LA PRÉPARATION DE DÉRIVÉS DE 3-AROYL-5-AMINOBENZOFURANNE

  摘要：

  本发明涉及一种制备3-芳酰基-5-氨基苯并呋喃衍生物的方法，该衍生物可用作抗心律失常药物，避免了使用硝基中间体。

  公开号：

  WO2012062918A1
• 作为产物：
  描述：

  对羟基苯乙酮 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 25.0h， 生成 4'-[3-(di-n-butylamino)propoxy]acetophenone
  参考文献：
  名称：

  Process for the preparation of 3-aroyl-5-aminobenzofuran derivatives

  摘要：

  本发明涉及一种制备3-芳酰基-5-氨基苯并呋喃衍生物的方法，用作抗心律失常药物，避免了使用硝基中间体。

  公开号：

  EP2452938A1

文献信息

• PROCESS FOR PREPARING BENZOFURAN DERIVATIVES SUBSTITUTED AT POSITION 5
  申请人：SANOFI

  公开号：US20130165674A1

  公开（公告）日：2013-06-27

  The disclosure relates to a process for preparing benzofuran derivatives of general formula I: in which R, R 1 , and R 2 are as defined in the disclosure; by coupling the hydroxylamine with a diketone of general formula III: in order to form an oxime that is then cyclized by heating in order to form the desired compound.

  该披露涉及一种制备一般式I的苯并呋喃衍生物的过程：其中R、R1和R2如披露中定义；通过将羟胺与一般式III的二酮偶联，以形成氧胺，然后通过加热环化以形成所需化合物。
• Process for preparing 2-Alkyl-3-aroyl-5-nitro-benzofurans
  申请人：Lonza Ltd.

  公开号：EP2246341A1

  公开（公告）日：2010-11-03

  The present invention relates to a process for the preparation of a compound of formula wherein R1 is selected from C1-6-alkyl, C3-6-cycloalkyl and aralkyl, and wherein R2 at each occurrence independently is halogen or C1-6-alkyl, and m is an integer from 0 to 4, Q is selected from halogen, -NO2 and -NR3R4, wherein R3 and R4 are independently selected from hydrogen, C1-6-alkyl, C1-6-cycloalkyl, aryl, aralkyl, mesyl and tosyl, or wherein R3 and R4 together form a C4-6-alkylene group, Y at each occurrence is hydrogen or a hydroxy protection group W that can be hydrolytically cleaved under acidic conditions, and n is an integer from 1 to 3, and n is an integer from 1 to 3, with the proviso that n and m together are not greater than 5.

  本发明涉及一种制备化合物的过程，其化学式为其中R1选自C1-6-烷基，C3-6-环烷基和芳基，R2在每个出现的位置独立地是卤素或C1-6-烷基，m是0到4的整数，Q选自卤素，-NO2和-NR3R4，其中R3和R4独立地选自氢，C1-6-烷基，C1-6-环烷基，芳基，芳基烷基，甲烷磺基和对甲苯磺基，或者R3和R4一起形成一个C4-6-烷基烯基基团，Y在每个出现的位置是氢或可在酸性条件下水解的羟基保护基W，n是1到3的整数，且n是1到3的整数，但要求n和m的总和不大于5。
• KETOBENZOFURAN DERIVATIVES, METHOD FOR SYNTHESIZING SAME, AND INTERMEDIATES
  申请人：BAILLY Frederic

  公开号：US20130012729A1

  公开（公告）日：2013-01-10

  The present disclosure relates to ketobenzofuran derivatives of the general formula (I): as well as to a method of synthesizing the same by coupling a quinonimine and an enaminone by a Nenitzescu reaction and to the intermediates of the synthesis thereof.

  本公开涉及一般式(I)的酮苯并呋喃衍生物，以及通过将醌亚胺和烯酰胺通过Nenitzescu反应偶联合成它们的方法，以及合成过程中的中间体。
• [EN] PROCESS FOR PREPARING 2-ALKYL-3-AROYL-5-NITRO-BENZOFURANS<br/>[FR] PROCÉDÉ DE PRÉPARATION DU 2-ALKYLE-3-AROYLE-5-NITRO-BENZOFURANE
  申请人：LONZA AG

  公开号：WO2010040261A1

  公开（公告）日：2010-04-15

  The present invention relates to a process for the preparation of a compound of formula (I), wherein R1 is selected from C1-6-alkyl, C3-6-cycloalkyl and aralkyl, and wherein R2 at each occurrence independently is halogen or C1-6-alkyl, and m is an integer from 0 to 4, Q is selected from halogen, -NO2 and -NR3R4, wherein R3 and R4 are independently selected from hydrogen, C1-6-alkyl, C3-6-cycloalkyl, aryl, aralkyl, mesyl and tosyl, or wherein R3 and R4 together form a C4-6-alkylene group, Y at each occurrence is hydrogen or a hydroxy protection group W that can be hydrolytically cleaved under acidic conditions, and n is an integer from 1 to 3, and n is an integer from 1 to 3, with the proviso that n and m together are not greater than 5.

  本发明涉及一种制备式(I)化合物的方法，其中R1从C1-6-烷基，C3-6-环烷基和芳基中选择，R2在每次出现时独立地为卤素或C1-6-烷基，m为0到4的整数，Q从卤素，-NO2和-NR3R4中选择，其中R3和R4独立地选择自氢，C1-6-烷基，C3-6-环烷基，芳基，芳基烷基，甲苯磺酰基和对甲苯磺酰基，或者R3和R4一起形成一个C4-6-烷基烯基，Y在每次出现时是氢或可在酸性条件下水解的羟基保护基W，n为1到3的整数，且n为1到3的整数，但须满足n和m的总和不大于5。
• PROCESS FOR PREPARING 2-ALKYL-3-AROYL-5-NITRO-BENZOFURANS
  申请人：Wellig Alain

  公开号：US20110178314A1

  公开（公告）日：2011-07-21

  The present invention relates to a process for the preparation of a compound of formula wherein R 1 is selected from C 1-6 -alkyl, C 3-6 -cycloalkyl and aralkyl, and wherein R 2 at each occurrence independently is halogen or C 1-6 -alkyl, and m is an integer from 0 to 4, Q is selected from halogen, —NO 2 and —NR 3 R 4 , wherein R 3 and R 4 are independently selected from hydrogen, C 1-6 -alkyl, C 3-6 -cycloalkyl, aryl, aralkyl, mesyl and tosyl, or wherein R 3 and R 4 together form a C 4-6 -alkylene group, Y at each occurrence is hydrogen or a hydroxy protection group W that can be hydrolytically cleaved under acidic conditions, and n is an integer from 1 to 3, and n is an integer from 1 to 3, with the proviso that n and m together are not greater than 5.

  本发明涉及一种制备符合以下结构的化合物的方法：其中R1选自C1-6-烷基、C3-6-环烷基和芳基，R2在每次出现时独立地是卤素或C1-6-烷基，m是0到4的整数，Q选自卤素、—NO2和—NR3R4，其中R3和R4独立地选自氢、C1-6-烷基、C3-6-环烷基、芳基、芳基烷基、甲磺酰基和对甲苯磺酰基，或者R3和R4一起形成一个C4-6-烷基烯基团，Y在每次出现时是氢或可在酸性条件下水解的羟基保护基W，n是1到3的整数，且n和m的总和不大于5。