2-endo-benzoylamino, bornane | 105615-60-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2-endo-benzoylamino, bornane
• 英文别名: N-bornyl-2-phenylacetamide；N-((1R)-bornyl)-benzamide；N-((1R)-Bornyl)-benzamid；Benzoylbornylamin；N-[(1R,2S,4R)-1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl]benzamide
• CAS: 105615-60-9
• 化学式: C₁₇H₂₃NO
• 分子量: 257.376
• InChiKey: NTWLHHBGBISWLH-KEYYUXOJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-endo-benzoylamino, bornane 生成 N-[(1R,2R,4S,5R)-5-hydroxy-1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl]benzamide
  参考文献：
  名称：

  FOURNERON, J. -D.;ARCHELAS, A.;VIGNE, B.;FURSTOSS, R., TETRAHEDRON, 43,(1987) N 10, 2273-2284

  摘要：

  DOI：
• 作为产物：
  描述：

  (+)-冰片 、 苯甲腈 在 SiO₂ coated on magnetic CoFe₂O₄ nanoparticle immobilized N-propyldiethylenetriamine sulfamic acid 作用下， 反应 4.0h， 以90%的产率得到2-endo-benzoylamino, bornane
  参考文献：
  名称：

  磁性CoFe 2 O 4纳米粒子固定化的N-丙基二亚乙基三胺氨基磺酸作为一种有效且可回收的催化剂，用于通过Ritter反应合成酰胺

  摘要：

  合成了磁性CoFe 2 O 4纳米颗粒固定化的二胺-N-氨基磺酸（CoFe 2 O 4 @SiO 2 -DASA），并用作无溶剂条件下通过Ritter反应合成酰胺的有效多相催化剂。通过施加外部磁体可以容易地回收磁性纳米催化剂，并循环几次，而不会显着降低其催化活性。

  DOI：

  10.1016/j.apcata.2014.06.006

文献信息

• Reliability of the time trade-off technique of utility assessment in patients with retinal disease
  作者：Hussein Hollands、Miu Lam、Joe Pater、Dave Albiani、Gary C. Brown、Melissa Brown、Alan F. Cruess、Sanjay Sharma

  DOI：10.1016/s0008-4182(01)80041-7

  日期：2001.6

  Background: Studies in medical fields other than ophthalmology have given conflicting results regarding the reliability of the time trade-off technique of utility assessment. We performed a study to determine the test-retest reliability of the time trade-off technique for assessing utilities in patients with ocular diseases of the retina and to investigate possible factors associated with differences in utility over time.Methods: Patients referred to the retina service of a tertiary care hospital in eastern Canada were eligible for the initial interview if they had best corrected vision of 20/30 or worse in at least one eye and were deemed competent to answer the required questions. Patients were interviewed prospectively between December 1999 and March 2000 during a normal 30-minute period needed for pharmacologic mydriasis to occur. Demographic, clinical (including Snellen visual acuity) and time trade-off utility information was collected through chart review and standardized interview. Patients who completed the interview successfully were called back 28 days later for follow-up.Results: Of the 138 eligible patients 112 (81.2%) completed the initial interview. Of the 112, 96 (85.7%) completed the second interview. Half of the respondents were women, and all but one respondent were white. The mean age was 65.3 years. The primary reasons for visual loss included diabetic retinopathy (59 patients [61.4%]) and age-related macular degeneration (14 patients [14.6%]). The intraclass correlation coefficient between the initial and follow-up visual utilities was 0.7634 (95% confidence interval 0.6655-0.8355).Interpretation: Our results show excellent reliability of the time trade-off technique of utility assessment in patients with ocular diseases of the retina.
• Microbial transformations. Part 7 (1) Biohydroxylation of bornylamide derivatives by the fungus beauveria sulfurescens
  作者：Jeen-Dominique Fourneron、Alain Archelas、Bernard Vigne、Roland Furstoss

  DOI：10.1016/s0040-4020(01)86811-3

  日期：——
• Frankland; Barrow, Journal of the Chemical Society, 1909, vol. 95, p. 2022
  作者：Frankland、Barrow

  DOI：——

  日期：——
• Magnetic CoFe2O4 nanoparticle immobilized N-propyl diethylenetriamine sulfamic acid as an efficient and recyclable catalyst for the synthesis of amides via the Ritter reaction
  作者：Xiao-Na Zhao、Hai-Chuan Hu、Fu-Jun Zhang、Zhan-Hui Zhang

  DOI：10.1016/j.apcata.2014.06.006

  日期：2014.7

  A magnetic CoFe2O4 nanoparticle immobilized diamine-N-sulfamic acid (CoFe2O4@SiO2–DASA) was synthesized and used as efficient heterogeneous catalyst for the synthesis of amides via the Ritter reaction under solvent-free conditions. The magnetic nanocatalyst could be readily recovered by applying an external magnet and recycled several times without considerable loss of its catalytic activity.

  合成了磁性CoFe 2 O 4纳米颗粒固定化的二胺-N-氨基磺酸（CoFe 2 O 4 @SiO 2 -DASA），并用作无溶剂条件下通过Ritter反应合成酰胺的有效多相催化剂。通过施加外部磁体可以容易地回收磁性纳米催化剂，并循环几次，而不会显着降低其催化活性。
• FOURNERON, J. -D.;ARCHELAS, A.;VIGNE, B.;FURSTOSS, R., TETRAHEDRON, 43,(1987) N 10, 2273-2284
  作者：FOURNERON, J. -D.、ARCHELAS, A.、VIGNE, B.、FURSTOSS, R.

  DOI：——

  日期：——