2-Butyl-8-chloro-3-propylquinoline | 1380437-87-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-Butyl-8-chloro-3-propylquinoline
• 英文别名: 2-butyl-8-chloro-3-propylquinoline
• CAS: 1380437-87-5
• 化学式: C₁₆H₂₀ClN
• 分子量: 261.794
• InChiKey: PYAJXFGYTWWYAB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-乙烯基吡咯烷酮 、 正戊醛 、 邻氯苯胺 在 bismuth(III) chloride 作用下， 以 乙腈 为溶剂， 反应 4.0h， 以70%的产率得到N-(8-chloro-2-methyl-1,2,3,4-tetrahydroquinolin-4-yl)pyrrolidin-2-one
  参考文献：
  名称：

  Simple entry to new 2-alkyl-1,2,3,4-tetrahydroquinoline and 2,3-dialkylquinoline derivatives using BiCl3-catalyzed three component reactions of anilines and aliphatic aldehydes in the presence (or lack) of N-vinyl amides

  摘要：

  A general protocol for the simple and efficient synthesis of 2-alkyl-1,2,3,4-tetrahydroquinolines and 2,3-dialkylquinolines was reported. Synthetic protocol describes the one-pot preparation of these tetrahydroquinoline and quinoline products using the same reagents (aliphatic aldehydes and anilines) in the BiCl3-catalyzed multicomponent condensation process where the third component, N-vinyl amide is present. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.04.008

文献信息

• Simple entry to new 2-alkyl-1,2,3,4-tetrahydroquinoline and 2,3-dialkylquinoline derivatives using BiCl3-catalyzed three component reactions of anilines and aliphatic aldehydes in the presence (or lack) of N-vinyl amides
  作者：Vladimir V. Kouznetsov、Carlos M. Meléndez Gómez、Fernando A. Rojas Ruíz、Esther del Olmo

  DOI：10.1016/j.tetlet.2012.04.008

  日期：2012.6

  A general protocol for the simple and efficient synthesis of 2-alkyl-1,2,3,4-tetrahydroquinolines and 2,3-dialkylquinolines was reported. Synthetic protocol describes the one-pot preparation of these tetrahydroquinoline and quinoline products using the same reagents (aliphatic aldehydes and anilines) in the BiCl3-catalyzed multicomponent condensation process where the third component, N-vinyl amide is present. (C) 2012 Elsevier Ltd. All rights reserved.