[(1R,3aR,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a,5a,5b,8,8,11a-hexamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysen-9-yl] 4-chlorobenzoate | 1186599-64-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: [(1R,3aR,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a,5a,5b,8,8,11a-hexamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysen-9-yl] 4-chlorobenzoate
• CAS: 1186599-64-3
• 化学式: C₃₇H₅₃ClO₂
• 分子量: 565.28
• InChiKey: SOIOSHBELCFZPN-WEZIXBNWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.7
• 重原子数：
  40
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  羽扇豆醇 、 对氯苯甲酸 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 以85%的产率得到[(1R,3aR,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a,5a,5b,8,8,11a-hexamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysen-9-yl] 4-chlorobenzoate
  参考文献：
  名称：

  Synthesis of novel triterpenoid (lupeol) derivatives and their in vivo antihyperglycemic and antidyslipidemic activity

  摘要：

  The triterpenoid, lupeol (1) has been isolated from the leaves extract of Aegle marmelos. Few novel derivatives (2-13) were synthesized from the naturally occurring lupeol (1) and screened for their antihyperglycemic activity (2-11) and antidyslipidemic activity (2-4 and 12-13). The derivative 4 lowered the blood glucose levels by 18.2% and 25.0% at 5 h and 24 h, respectively, in sucrose challenged streptozotocin induced diabetic rats (STZ-S) model at the dose of 100 mg/kg body weight. The compound 4 also significantly lowered 40% (P <0.001) in triglycerides, 30% (P <0.05) in glycerol, 24% (P <0.05) in cholesterol quantity and also improved the HDL-cholesterol by 5% in dyslipidemic hamster model at the dose of 50 mg/kg b.wt. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.05.034

文献信息

• COMPOSITION PHARMACEUTIQUE DESTINÉE À INHIBER L'INFECTIOSITÉ DU VIH, À TRAITER LE SYNDROME D'IMMUNODÉFICIENCE ACQUISE (SIDA) ET SES COMPLICATIONS
  申请人：Monkam Nitcheu, Guy Faustin

  公开号：EP3785709A1

  公开（公告）日：2021-03-03

  La présente invention concerne une composition pharmaceutique utilisée pour inhiber la pénétration d'agents pathogènes dans les cellules cibles. Elle peut être également utilisée dans la prévention ou le traitement d'infections par le VIH, empêche l'apparition ou la progression du sida et ses différentes conséquences.

  本发明涉及一种用于抑制病原体渗透到靶细胞的药物组合物。它还可用于预防或治疗艾滋病病毒感染，防止艾滋病及其各种后果的发生或发展。
• The Pharmaceutical Composition Intended to Inhibit HIV Infectivity in Order to Treat the Acquired Immune Deficiency Syndrome (AIDS) and Its Complications
  申请人：Monkam Nitcheu Guy Faustin

  公开号：US20210060034A1

  公开（公告）日：2021-03-04

  This invention relates to a pharmaceutical composition used to inhibit pathogenic agents from penetrating target cells. It can also be used in the prevention or treatment of HIV infections, prevent the appearance or advance of AIDS and its various consequences.