Diolein | 25637-84-7

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: Diolein
• 英文别名: glyceryl dioleate；1-Oleyl-3-elaidyl-glycerin；9-Octadecenoic acid (9Z)-, diester with 1,2,3-propanetriol；[2-hydroxy-3-[(E)-octadec-9-enoyl]oxypropyl] (Z)-octadec-9-enoate
• CAS: 25637-84-7
• 化学式: C₃₉H₇₂O₅
• 分子量: 620.998
• InChiKey: DRAWQKGUORNASA-YAFCTCPESA-N

物化性质

• 溶解度：
  DMF：10mg/mL；乙醇：10mg/mL；乙醇:PBS (pH 7.2) (1:1): 0.5 mg/mL
• 密度：
  0.89-0.92 g/cm3(Temp: 50 °C)
• 熔点：
  12 °C
• LogP：
  15.178 (est)
• 物理描述：
  Liquid; OtherSolid

计算性质

• 辛醇/水分配系数(LogP)：
  14.3
• 重原子数：
  44
• 可旋转键数：
  36
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

制备方法与用途

用途

二油酸甘油酯可用于治疗乳腺癌。

文献信息

• AGENTS FOR MAINTAINING UNDIFFERENTIATED STATE AND PROMOTING PROLIFERATION OF STEM CELLS
  申请人：NIPPON MENARD COSMETIC CO., LTD.

  公开号：US20170320809A1

  公开（公告）日：2017-11-09

  An object of the present invention is to find a novel substance that is capable of efficiently promoting the proliferation of stem cells while maintaining the undifferentiated state thereof and to provide the substance as an agent for maintaining the undifferentiated state of stem cells or an agent for promoting the proliferation of stem cells. Another object of the present invention is to provide an agent for treating a wound that has a wound healing effect on the skin and is readily available in the field of skin regenerative medicine or cosmetic treatment, and safe and inexpensive. The present invention relates to an agent for maintaining the undifferentiated state or promoting the proliferation of stem cells or an agent for treating a wound, comprising, as an active ingredient, one or a mixture of two or more of fatty acid glycerides represented by the following general formula (I): wherein at least one of R 1 , R 2 , and R 3 represents an acyl group derived from an unsaturated fatty acid having 16 to 22 carbon atoms and the others each represent an acyl group derived from a saturated fatty acid or a hydrogen atom.

  本发明的目的是寻找一种新的物质，能够高效地促进干细胞的增殖，同时保持其未分化状态，并将该物质作为维持干细胞未分化状态的药剂或促进干细胞增殖的药剂提供。本发明的另一个目的是提供一种治疗伤口的药剂，该药剂对皮肤具有愈合作用，在皮肤再生医学或美容治疗领域中易得，且安全且价格便宜。本发明涉及一种维持干细胞未分化状态或促进干细胞增殖或治疗伤口的药剂，其包括以下通式（I）所表示的脂肪酸甘油酯之一或两种或更多种混合物作为活性成分：其中R1、R2和R3中至少有一个代表由具有16到22个碳原子的不饱和脂肪酸衍生的酰基，其他各自代表由饱和脂肪酸或氢原子衍生的酰基。
• Agents for maintaining undifferentiated state and promoting proliferation of stem cells
  申请人：NIPPON MENARD COSMETIC CO., LTD.

  公开号：US10259772B2

  公开（公告）日：2019-04-16

  An object of the present invention is to find a novel substance that is capable of efficiently promoting the proliferation of stem cells while maintaining the undifferentiated state thereof and to provide the substance as an agent for maintaining the undifferentiated state of stem cells or an agent for promoting the proliferation of stem cells. Another object of the present invention is to provide an agent for treating a wound that has a wound healing effect on the skin and is readily available in the field of skin regenerative medicine or cosmetic treatment, and safe and inexpensive. The present invention relates to an agent for maintaining the undifferentiated state or promoting the proliferation of stem cells or an agent for treating a wound, comprising, as an active ingredient, one or a mixture of two or more of fatty acid glycerides represented by the following general formula (I): wherein at least one of R1, R2, and R3 represents an acyl group derived from an unsaturated fatty acid having 16 to 22 carbon atoms and the others each represent an acyl group derived from a saturated fatty acid or a hydrogen atom.

  本发明的一个目的是找到一种新型物质，该物质能够有效促进干细胞增殖，同时保持干细胞的未分化状态，并提供该物质作为保持干细胞未分化状态的制剂或促进干细胞增殖的制剂。本发明的另一个目的是提供一种用于治疗伤口的药剂，该药剂对皮肤具有伤口愈合效果，并且在皮肤再生医学或美容治疗领域容易获得，安全且价格低廉。本发明涉及一种维持干细胞未分化状态或促进干细胞增殖的制剂或一种治疗伤口的制剂，其活性成分包括一种或两种以上由下式通式（I）代表的脂肪酸甘油酯的混合物： 其中，R1、R2 和 R3 中至少有一个代表源自具有 16 至 22 个碳原子的不饱和脂肪酸的酰基，其他各代表源自饱和脂肪酸的酰基或氢原子。
• Use of aldehydes formulated with nanoparticles and/or nanoemulsions to enhance disease resistance of plants to liberibacters
  申请人：UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

  公开号：US10772326B2

  公开（公告）日：2020-09-15

  Methods and compositions based upon natural phenolic aromatic aldehydes (ex: cinnamaldehyde, benzaldehyde) are provided, which find use as curing agents for systemic bacterial infections of living plants, in particular against Gram negative bacteria and more particularly species of Liberibacter, including Ca. Liberibacter asiaticus. The curing agent compositions described are used synergistically with other antimicrobial compounds, such as those that plants manufacture or release as a result of biotic or abiotic stresses, including the application of the subject aldehydes, certain proteins, whether produced by recombinant methods or not, nanoparticles, nanoemulsions, or by natural essential oils such as carvacrol or allicin. The aromatic aldehydes have high volatility and exhibit phytotoxicity when applied above certain amounts. Systemic infections and infestations of a variety of plant parts can be treated, including those of leaves and roots. Methods of applying the compositions for agriculture use are disclosed.

  提供了基于天然酚类芳香醛（例如：肉桂醛、苯甲醛）的方法和组合物，可用作活体植物系统性细菌感染的固化剂，特别是针对革兰氏阴性细菌，尤其是自由杆菌的种类，包括Ca.asiaticus）。所述固化剂组合物可与其他抗微生物化合物协同使用，例如植物在生物或非生物胁迫下制造或释放的化合物，包括应用所述醛类、某些蛋白质（无论是否通过重组方法生产）、纳米颗粒、纳米乳液或天然精油（如香芹酚或大蒜素）。芳香醛具有高挥发性，施用超过一定量时会产生植物毒性。可以治疗多种植物部位的系统感染和侵染，包括叶片和根部的感染和侵染。此外，还公开了用于农业用途的组合物的施用方法。
• USE OF ALDEHYDES FORMULATED WITH NANOPARTICLES AND/OR NANOEMULSIONS TO ENHANCE DISEASE RESISTANCE OF PLANTS TO LIBERIBACTERS
  申请人：UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

  公开号：US20170006863A1

  公开（公告）日：2017-01-12

  Methods and compositions based upon natural phenolic aromatic aldehydes (ex: cinnamaldehyde, benzaldehyde) are provided, which find use as curing agents for systemic bacterial infections of living plants, in particular against Gram negative bacteria and more particularly species of Liberibacter, including Ca. Liberibacter asiaticus. The curing agent compositions described are used synergistically with other antimicrobial compounds, such as those that plants manufacture or release as a result of biotic or abiotic stresses, including the application of the subject aldehydes, certain proteins, whether produced by recombinant methods or not, nanoparticles, nanoemulsions, or by natural essential oils such as carvacrol or allicin. The aromatic aldehydes have high volatility and exhibit phytotoxicity when applied above certain amounts. Systemic infections and infestations of a variety of plant parts can be treated, including those of leaves and roots. Methods of applying the compositions for agriculture use are disclosed.
• ALL PURPOSE CLEANER, DISINFECTANT, DUST SUPPRESSANT, BIOAEROSOL PARTICLE REMOVER, AND PESTICIDE MICROEMULSION FORMULATION AND METHOD OF USE
  申请人：BOND Jerry R.

  公开号：US20220202020A1

  公开（公告）日：2022-06-30

  An all 25(b) botanical food grade, all purpose cleaner, anti-microbial and disinfectant includes a microemulsion that contains effective amounts of the ingredients of thyme oil, wintergreen oil, a surfactant, citric acid, and isopropanol. The ingredients combined with water to produce a clear microemulsion for application as a cleaner/disinfectant as well as treating growing and harvested crops, animals and pets for pesticide purposes and as a dust suppressant and to disrupt bioaerosols in the air and/or remove them from the air. Areas of treatment can include hospitals, homes, construction sites, open areas outside, laboratories, and the like.