| 14564-74-0

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物 - 环羧酸
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 14564-74-0
• 化学式: C18H30KO3S
• 分子量: 365.6
• InChiKey: YVSMNLKLBZFOCN-UHFFFAOYSA-N

物化性质

• 熔点：
  >182°C (dec.)
• 溶解度：
  甲醇（微溶，加热），水（微溶）

计算性质

• 辛醇/水分配系数(LogP)：
  5.02
• 重原子数：
  23
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  62.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• DEPROTECTION METHOD FOR TETRAZOLE COMPOUND
  申请人：API CORPORATION

  公开号：US20150239854A1

  公开（公告）日：2015-08-27

  The present invention relates to a method of deprotecting a tetrazole compound, useful as an intermediate for angiotensin II receptor blockers, and provides a novel production method of angiotensin II receptor blockers. Provided is a production method of a compound represented by the formula [3] or [4] or a salt thereof, including (i) reducing a compound represented by the formula [1] or [2] or a salt thereof in the presence of a metal catalyst and an alkaline earth metal salt, or (ii) reacting the compound with a particular amount of Brønsted acid: wherein each symbol is as defined in the present specification.

  本发明涉及一种去保护四唑化合物的方法，该方法作为血管紧张素II受体拮抗剂的中间体，并提供了一种新颖的血管紧张素II受体拮抗剂的生产方法。 提供了一种由式[3]或[4]表示的化合物或其盐的生产方法，包括(i)在金属催化剂和碱土金属盐的存在下还原式[1]或[2]表示的化合物或其盐，或(ii)将该化合物与特定量的Brønsted酸反应： 其中每个符号如本说明书中所定义。
• PHARMACEUTICAL COMPOSITIONS AND FORMULATIONS INCLUDING INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME
  申请人：Kirkpatrick D. Lynn

  公开号：US20120189670A1

  公开（公告）日：2012-07-26

  Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.

  本文描述了与Pleckstrin同源结构域结合的化合物，包括这些化合物的药物组合物，以及其使用方法。
• SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME
  申请人：Mahadevan Daruka

  公开号：US20110144066A1

  公开（公告）日：2011-06-16

  Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.

  本文描述了Pleckstrin homology domain结合化合物、包括这些化合物的制药组合物以及它们的使用方法。
• Process for the preparation of modified polybutylene terephthalate resin
  申请人：POLYPLASTICS CO. LTD.

  公开号：EP0678552A1

  公开（公告）日：1995-10-25

  The present invention provides a process for the preparation of a polyester from an acid component comprising terephthalic acid or a lower alcohol ester thereof as a main component and a diol component comprising 1,4-butanediol as a main component, wherein 0.001 to 0.5 mol % (based on the acid component) of a specific aromatic sulfonic acid compound is dissolved in the diol component or a mixture of the diol component with the acid component and thereafter a catalyst is added to the resulting reaction system to conduct esterification (or transesterification) and polycondensation successively, for the purpose of providing a modified polybutylene terephthalate resin which little generates gas such as tetrahydrofuran even in high-temperature service and little gives sublimate in melting.

  本发明提供了一种由包括对苯二甲酸或其低级醇酯作为主要成分的酸组分和包括 1,4-丁二醇作为主要成分的二元醇组分制备聚酯的工艺，其中 0.001 至 0.5 mol %（以酸组分为基准）的特定芳香族磺酸化合物溶解在二元醇组分或二元醇组分与酸组分的混合物中，然后向生成的反应体系中添加催化剂，以先后进行酯化（或酯交换）和缩聚反应，目的是提供一种改性聚对苯二甲酸丁二醇酯树脂，这种树脂即使在高温下使用也很少产生四氢呋喃等气体，在熔化时也很少产生亚硝酸盐。
• Antistatic agent for synthetic polymer materials and method of application thereof
  申请人：Takemoto Yushi Kabushiki Kaisha

  公开号：EP1000969A1

  公开（公告）日：2000-05-17

  An antistatic agent having a phosphonium sulfonate of formula (1) and an inorganic sulfonate of formula (2) where A1 and A2 are each independently an alkyl group with 1-36 carbon atoms, an alkenyl group with 4-24 carbon atoms, a phenyl group, a phenyl group substituted by an alkyl group with 1-18 carbon atoms, a naphthyl group or a naphthyl group substituted by an alkyl group with 1-18 carbon atoms; R1, R2, R3 and R4 are each independently an aliphatic or aromatic hydrocarbon group with 1-18 carbon atoms or a hydrocarbon group substituted by a hydroxyl or cyano group; Mn+ is an alkali metal cation if n = 1 and an alkaline-earth metal cation if n = 2; and n = 1 or 2, can provide synthetic polymer materials with a superior antistatic characteristic without adversely affecting the natural hue and transparency of the material. An aliphatic carboxylic acid ester of a polyhydric alcohol may also be mixed together in the agent.

  一种抗静电剂，具有式(1)的鏻磺酸盐和式(2)的无机磺酸盐 其中 A1 和 A2 各自独立地为具有 1-36 个碳原子的烷基、具有 4-24 个碳原子的烯基、苯基、被具有 1-18 个碳原子的烷基取代的苯基、萘基或被具有 1-18 个碳原子的烷基取代的萘基；R1、R2、R3 和 R4 分别独立地为具有 1-18 个碳原子的脂肪族或芳香族烃基，或被羟基或氰基取代的烃基；如果 n = 1，则 Mn+ 为碱金属阳离子；如果 n = 2，则为碱土金属阳离子；以及 n = 1 或 2，可使合成聚合物材料具有优异的抗静电特性，而不会对材料的天然色调和透明度产生不利影响。还可以在药剂中混入多羟基乙醇的脂肪族羧酸酯。