(-)-N-(4,5,6,7-tetrahydro-7-oxobenzo[b]thien-4-yl)formamide | 58095-37-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (-)-N-(4,5,6,7-tetrahydro-7-oxobenzo[b]thien-4-yl)formamide
• 英文别名: N-formyl-4,5,6,7-tetrahydro-7-oxobenzo[b]-thiophen-4-amine；N-(4,5,6,7-tetrahydro-7-oxobenzo[b]thien-4-yl)-formamide；N-formyl-4,5,6,7-tetrahydro-7-oxobenzo-[b]thiophen-4-amine；N-formyl-4,5,6,7-tetrahydro-7-oxobenzo[b]thiophen-4-amine；N-(7-Oxo-4,5,6,7-tetrahydro-1-benzothiophen-4-yl)formamide；N-(7-oxo-5,6-dihydro-4H-1-benzothiophen-4-yl)formamide
• CAS: 58095-37-7；64607-54-1；64607-55-2
• 化学式: C₉H₉NO₂S
• 分子量: 195.242
• InChiKey: OVYSXAZBCBIOSB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  74.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (-)-N-(4,5,6,7-tetrahydro-7-oxobenzo[b]thien-4-yl)formamide 在 盐酸 、 sodium hydroxide 、 二氧化锰 、 sodium borohydrid 、 二氧化碳 、 溶剂黄146 、 paraformaldehyde 作用下， 以 甲醇 、 乙醇 、 正己烷 、 水 、 丙酮 为溶剂， 生成 1-(methoxymethyl)-3-(4,5,6,7-tetrahydro-7-oxobenzo[b]thien-4-yl)urea
  参考文献：
  名称：

  Compositions containing 4,5,6,7-tetrahydrobenz[b]thien-4-yl-ureas or

  摘要：

  这份披露描述了一种新颖的方法，通过向兽医同温动物投予一定量的环戊烷基硫代脲或硫脲，以提高饲料效率并加快生长速度。

  公开号：

  US04036979A1
• 作为产物：
  描述：

  4,5,6,7-tetrahydrobenzo[b]thiophen-4-amine 在 甲酸 、 cerium (IV) ammonium nitrate 作用下， 以 乙醚 、 水 、 溶剂黄146 、 甲苯 为溶剂， 生成 (-)-N-(4,5,6,7-tetrahydro-7-oxobenzo[b]thien-4-yl)formamide
  参考文献：
  名称：

  Compositions containing 4,5,6,7-tetrahydrobenz[b]thien-4-yl-ureas or

  摘要：

  这份披露描述了一种新颖的方法，通过向兽医同温动物投予一定量的环戊烷基硫代脲或硫脲，以提高饲料效率并加快生长速度。

  公开号：

  US04036979A1

文献信息

• 4,5,6,7-Tetra hydro-7-oxobenzo(B)thien-4-yl isocyanate and isothiocyanate
  申请人：American Cyanamid Company

  公开号：US03994924A1

  公开（公告）日：1976-11-30

  The present invention relates to 4,5,6,7-tetrahydro-7-oxobenzo[b]thien-4-yl isocyanate and isothiocyanate, which are novel and useful intermediates for the preparation of 4,5,6,7-tetrahydro-7-oxobenzo[b]thien-4-ylurea and thiourea compounds which are animal growth promoters. The present invention also relates to methods of preparation for the above-identified thienyl isocyanates and isothiocyanates.

  本发明涉及4,5,6,7-四氢-7-氧代苯并[b]噻-4-基异氰酸酯和异硫氰酸酯，它们是制备动物生长促进剂4,5,6,7-四氢-7-氧代苯并[b]噻-4-基脲和硫脲化合物的新颖且有用的中间体。本发明还涉及上述噻基异氰酸酯和异硫氰酯的制备方法。
• 1,3-Dithiolane compounds and method of preparation thereof
  申请人：American Cyanamid Company

  公开号：US04075228A1

  公开（公告）日：1978-02-21

  There are provided substituted 1,3-dithiolane compounds and a method for preparing the same. Said 1,3-dithiolane compounds are useful intermediates in the preparation of tetrahydro-7-oxobenzo[b]thien-4-ylureas and tetrahydro-4-oxo-1-naphthylureas which are known animal growth-promoting agents, which thiolanes are represented by the formula: ##STR1## wherein R.sub.1 is a member selected from the group consisting of 2-thienyl and phenyl; R.sub.2 is a member selected from the group consisting of ##STR2## wherein X is chlorine or bromine; R.sub.3 and R.sub.4 are each members selected from the group consisting of hydrogen and methyl; and when R.sub.1 and R.sub.2 are taken together with the carbon atom to which they are attached they represent a bicyclic moiety selected from the group consisting of ##STR3## wherein the carbon atom of said bicyclic moiety marked with an asterisk is also part of the 1,3-dithiolane ring; U is a moiety selected from the group consisting of ##STR4## and when U is ##STR5## said compounds are the racemic mixtures and the optical isomers thereof.

  提供了替代的1,3-二硫杂环化合物及其制备方法。所述1,3-二硫杂环化合物是制备已知的动物生长促进剂四氢-7-氧代苯并[b]噻唑-4-基脲和四氢-4-氧代-1-萘基脲的有用中间体，该硫杂环的化学式为：##STR1## 其中R.sub.1是从2-噻吩基和苯基中选择的成员；R.sub.2是从##STR2## 中选择的成员，其中X是氯或溴；R.sub.3和R.sub.4是从氢和甲基中选择的成员；当R.sub.1和R.sub.2与它们连接的碳原子一起被选为从##STR3## 中选择的双环基团时，它们代表一个双环基团，其中带有星号的双环基团的碳原子也是1,3-二硫杂环的一部分；U是从##STR4## 中选择的基团；当U是##STR5## 时，所述化合物是外消旋混合物及其光学异构体。
• Novel 4,5,6,7-tetrahydro-7-oxy(oxy)benzo [b]thiophen-4-amine compounds
  申请人：American Cyanamid Company

  公开号：US04134899A1

  公开（公告）日：1979-01-16

  This invention relates to novel derivatives of 4,5,6,7-tetrahydro-7-oxo(oxy)benzo[b]thiophen-4-amine which are useful as animal growth regulants, and a process for the preparation thereof. The above-identified compounds of this invention are also useful as intermediates for the preparation of 4,5,6,7-tetrahydro-7-oxo(oxy)benzo[b]thien-4-ylurea compounds.

  本发明涉及4,5,6,7-四氢-7-氧(氧)苯并[b]噻吩-4-胺的新衍生物，其可用作动物生长调节剂，并提供其制备方法。本发明中所述的上述化合物也可用作制备4,5,6,7-四氢-7-氧(氧)苯并[b]噻吩-4-基脲化合物的中间体。
• Substituted tetrahydrobenzothiophenes and method of preparation thereof
  申请人：American Cyanamid Company

  公开号：US04156670A1

  公开（公告）日：1979-05-29

  This disclosure describes novel 4,5,6,7-tetrahydrobenzo[b]thien-4-ylureas useful as herbicidal agents and animal growth regulants and processes for the preparation thereof.

  本公开说明了作为除草剂和动物生长调节剂有用的新型4,5,6,7-四氢苯并[b]噻唑-4-基脲以及其制备方法。
• Substituted tetrahydrobenzothiophenes
  申请人：American Cyanamid Company

  公开号：US04191830A1

  公开（公告）日：1980-03-04

  This disclosure describes novel 4,5,6,7-tetrahydrobenzo[b]thien-4-ylureas useful as herbicidal agents and animal growth regulants and processes for the preparation thereof.

  本公开说明了一种新型的4,5,6,7-四氢苯并[b]噻唑-4-基脲，可用作除草剂和动物生长调节剂，并提供了其制备方法。