N-[(4,5,6,7-四氢苯并[b]噻吩)-4-基]甲酰胺 | 58094-06-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 中文名称: N-[(4,5,6,7-四氢苯并[b]噻吩)-4-基]甲酰胺
• 英文名称: N-formyl-4,5,6,7-tetrahydrobenzo[b]thiophen-4-amine
• 英文别名: N-(4,5,6,7-tetrahydrobenzo[b]thien-4-yl)formamide；N-formyl-4,5,6,7tetrahydrobenzo[b]thiophen-4-amine；N-formyl-4,5,6,7-tetrahydrobenzo[b]thien-4-amine；Formamide, N-(4,5,6,7-tetrahydrobenzo[b]thien-4-yl)-；N-(4,5,6,7-tetrahydro-1-benzothiophen-4-yl)formamide
• CAS: 58094-06-7
• 化学式: C₉H₁₁NOS
• 分子量: 181.258
• InChiKey: SJFXHSBXVOAPJM-UHFFFAOYSA-N

物化性质

• 沸点：
  384.6±21.0 °C(Predicted)
• 密度：
  1.21±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  57.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-[(4,5,6,7-四氢苯并[b]噻吩)-4-基]甲酰胺 在 cerium (IV) ammonium nitrate 、 sodium chloride 作用下， 以 溶剂黄146 为溶剂， 生成 (-)-N-(4,5,6,7-tetrahydro-7-oxobenzo[b]thien-4-yl)formamide
  参考文献：
  名称：

  Novel 4,5,6,7-tetrahydro-7-oxy(oxy)benzo [b]thiophen-4-amine compounds

  摘要：

  本发明涉及4,5,6,7-四氢-7-氧(氧)苯并[b]噻吩-4-胺的新衍生物，其可用作动物生长调节剂，并提供其制备方法。本发明中所述的上述化合物也可用作制备4,5,6,7-四氢-7-氧(氧)苯并[b]噻吩-4-基脲化合物的中间体。

  公开号：

  US04134899A1
• 作为产物：
  描述：

  4,5,6,7-tetrahydrobenzo[b]thiophen-4-amine 在 甲酸 作用下， 以 甲苯 为溶剂， 生成 N-[(4,5,6,7-四氢苯并[b]噻吩)-4-基]甲酰胺
  参考文献：
  名称：

  Novel 4,5,6,7-tetrahydro-7-oxy(oxy)benzo [b]thiophen-4-amine compounds

  摘要：

  本发明涉及4,5,6,7-四氢-7-氧(氧)苯并[b]噻吩-4-胺的新衍生物，其可用作动物生长调节剂，并提供其制备方法。本发明中所述的上述化合物也可用作制备4,5,6,7-四氢-7-氧(氧)苯并[b]噻吩-4-基脲化合物的中间体。

  公开号：

  US04134899A1

文献信息

• Compositions containing 4,5,6,7-tetrahydrobenz[b]thien-4-yl-ureas or
  申请人：American Cyanamid Company

  公开号：US04036979A1

  公开（公告）日：1977-07-19

  This disclosure describes a novel method for improving feed efficiency and accelerating the growth rate of veterinary homothermic animals by administering to said animals a growth-promoting amount of a cycloalkano[b]thien-4-ylurea or thiourea.

  这份披露描述了一种新颖的方法，通过向兽医同温动物投予一定量的环戊烷基硫代脲或硫脲，以提高饲料效率并加快生长速度。
• 4,5,6,7-Tetra hydro-7-oxobenzo(B)thien-4-yl isocyanate and isothiocyanate
  申请人：American Cyanamid Company

  公开号：US03994924A1

  公开（公告）日：1976-11-30

  The present invention relates to 4,5,6,7-tetrahydro-7-oxobenzo[b]thien-4-yl isocyanate and isothiocyanate, which are novel and useful intermediates for the preparation of 4,5,6,7-tetrahydro-7-oxobenzo[b]thien-4-ylurea and thiourea compounds which are animal growth promoters. The present invention also relates to methods of preparation for the above-identified thienyl isocyanates and isothiocyanates.

  本发明涉及4,5,6,7-四氢-7-氧代苯并[b]噻-4-基异氰酸酯和异硫氰酸酯，它们是制备动物生长促进剂4,5,6,7-四氢-7-氧代苯并[b]噻-4-基脲和硫脲化合物的新颖且有用的中间体。本发明还涉及上述噻基异氰酸酯和异硫氰酯的制备方法。
• Process for preparation 4,5,6,7-tetrahydro-7-oxobenzo-[b]-thiophenes and
  申请人：American Cyanamid Company

  公开号：US04254268A1

  公开（公告）日：1981-03-03

  There is provided an oxidation process using potassium permanganate as oxidizing agent, for the preparation of certain animal growth promoters, namely, N-(4,5,6,7-tetrahydro-7-oxobenzo[b]thien-4-yl)amides, 4,5,6,7-tetrahydro-7-oxobenzo[b]-thien-4-ylureas, N-(1,2,3,4-tetrahydro-4-oxo-1-naphthyl)amides and 1,2,3,4-tetrahydro-4-oxo-1-naphthylureas, said process affording such compounds in markedly improved yields, and being readily suitable for scale-up.

  提供了一种使用高锰酸钾作为氧化剂的氧化过程，用于制备某些动物生长促进剂，即N-(4,5,6,7-四氢-7-氧代苯并[b]噻吩-4-基)酰胺，4,5,6,7-四氢-7-氧代苯并[b]噻吩-4-基脲，N-(1,2,3,4-四氢-4-氧代-1-萘基)酰胺和1,2,3,4-四氢-4-氧代-1-萘基脲，该过程大大提高了这些化合物的产量，并且易于扩大规模。
• Benzothienylisocyanates and isothiocyanates and method of preparation
  申请人：American Cyanamid Company

  公开号：US03944567A1

  公开（公告）日：1976-03-16

  This invention relates to 4,5,6,7-tetrahydrobenzo[b]b]thien-4-yl isocyanates and 4,5,6,7-tetrahydrobenzo[b]thien-4-yl isothiocyanates and methods for the preparation thereof. These compounds are useful in the manufacture of substituted urea derivatives which are useful as animal growth regulants and herbicides.

  本发明涉及4,5,6,7-四氢苯并[b]噻吩-4-基异氰酸酯和4,5,6,7-四氢苯并[b]噻吩-4-基异硫氰酸酯及其制备方法。这些化合物在制造取代脲衍生物方面非常有用，这些衍生物可用作动物生长调节剂和除草剂。
• Substituted tetrahydrobenzothiophenes and method of preparation thereof
  申请人：American Cyanamid Company

  公开号：US04156670A1

  公开（公告）日：1979-05-29

  This disclosure describes novel 4,5,6,7-tetrahydrobenzo[b]thien-4-ylureas useful as herbicidal agents and animal growth regulants and processes for the preparation thereof.

  本公开说明了作为除草剂和动物生长调节剂有用的新型4,5,6,7-四氢苯并[b]噻唑-4-基脲以及其制备方法。