8-[[4-methyl-3-[[3-[[3-[[2-methyl-5-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl]carbamoyl]phenyl]carbamoylamino]benzoyl]amino]benzoyl]amino]naphthalene-1,3,5-trisulfonic acid | 129-46-4

• 物质功能分类: 原料药 - 抗寄生虫病药
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 8-[[4-methyl-3-[[3-[[3-[[2-methyl-5-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl]carbamoyl]phenyl]carbamoylamino]benzoyl]amino]benzoyl]amino]naphthalene-1,3,5-trisulfonic acid
• 英文别名: 8-[[3-[[3-[N-carbamoyl-3-[[2-methyl-5-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl]carbamoyl]anilino]benzoyl]amino]-4-methylbenzoyl]amino]naphthalene-1,3,5-trisulfonic acid
• CAS: 129-46-4
• 化学式: C₅₁H₄₀N₆O₂₃S₆
• 分子量: 1297.3
• InChiKey: ZFQRDUONLPXTNR-UHFFFAOYSA-N

物化性质

• 熔点：
  >260°C (dec.)
• 溶解度：
  H2O:>10mg/mL

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  86
• 可旋转键数：
  16
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  539
• 氢给体数：
  11
• 氢受体数：
  23

安全信息

• 危险品标志：
  Xn
• WGK Germany：
  3
• RTECS号：
  QM7000000
• 安全说明：
  S22,S24/25
• 危险类别码：
  R22,R36/38
• 危险性防范说明：
  P261,P280,P301+P312,P302+P352,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335
• 储存条件：
  0-6°C

SDS

Name:	Suramin.hexasodium salt Material Safety Data Sheet
Synonym:
CAS:	129-46-4

Section 1 - Chemical Product MSDS Name:Suramin.hexasodium salt Material Safety Data Sheet
Synonym:

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
129-46-4	Suramin.hexasodium salt		204-949-3

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Not available.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
Not available.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

---

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

---

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

---

Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.
Keep refrigerated. (Store below 4C/39F.)

---

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 129-46-4: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

---

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Powder
Color: white
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: Soluble.
Specific Gravity/Density:
Molecular Formula: C51H34N6O23S6Na6
Molecular Weight: 1428.5632

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide, sodium oxide.
Hazardous Polymerization: Will not occur.

---

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 129-46-4: QM7000000 LD50/LC50:
Not available.
Carcinogenicity:
Suramin.hexasodium salt - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

---

Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

---

Section 14 - TRANSPORT INFORMATION

IATA
No information available.
IMO
No information available.
RID/ADR
No information available.

---

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 129-46-4: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 129-46-4 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 129-46-4 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

背景

苏拉明钠（suramin），又称舒拉明钠或苏拉明，是德国Bayer AG公司于1961年合成的一种抗锥虫类化合物，主要用于治疗非洲锥虫病和盘尾丝虫病。20世纪80年代，有学者发现苏拉明钠能够抑制肿瘤病毒相关的逆转录酶活性，并将其应用于获得性免疫缺陷综合症（AIDS）的治疗，表明苏拉明钠对人类免疫缺陷病毒（HIV）有一定的抑制作用。

简介

苏拉明钠是一种可逆的竞争性蛋白酪氨酸磷酸酶 (PTPases) 抑制剂。它也是有效的sirtuins抑制剂：SirT1 (IC50=297 nM)，SirT2 (IC50=1.15 μM)，SirT5 (IC50=22 μM)。苏拉明钠是竞争性逆转录酶抑制剂（DNA topoisomerase II: IC50=5 μM），并且有效抑制IP5K，具有抗寄生虫、抗肿瘤和抗血管生成的特性。

应用

苏拉明钠已被证实具有抗锥虫病、抗肿瘤、防治眼部增殖性疾病、抗病毒以及免疫调节等作用，并广泛应用于临床。然而，尽管其对HIV有一定的抑制作用，但目前尚未发现其在治疗AIDS方面的广泛应用证据。此外，关于其是否能有效用于其他病毒感染的研究仍在进行中。

体内和体外研究 体内研究

苏拉明钠（10 mg/kg；静脉注射；每周两次共三周）逆转了成年雄性Wistar大鼠已建立的肺动脉高压（PH），从而恢复正常肺动脉压力值及血管结构。

研究详情

• 动物模型：成年雄性Wistar大鼠（200-225 g）
• 剂量：10 mg/kg
• 给药方式：静脉注射；每周两次共三周
• 结果：逆转了已建立的肺动脉高压，恢复正常肺动脉压力值及血管结构。

体外研究 细胞增殖试验

• 细胞系：HO-8910 PM卵巢癌细胞和Hela宫颈癌细胞
• 浓度：50, 100, 200, 300, 400, 500 和600 μg/mL
• 孵育时间：24、48、72和96小时
• 结果：剂量和时间依赖性地抑制细胞增殖

细胞凋亡分析

• 细胞系：Hela细胞
• 浓度：300 μg/mL
• 孵育时间：48小时
• 结果：诱导细胞凋亡

蛋白质印迹分析

• 细胞系：PA-SMCs细胞
• 浓度：1 mg/mL
• 孵育时间：1小时
• 结果：显著抑制磷酸化ERK1/2的表达

文献信息

• [EN] CAMP DEPENDENT INDUCTION OF AUTOPHAGY<br/>[FR] INDUCTION D'AUTOPHAGIE DÉPENDANTE DE L'AMP CYCLIQUE
  申请人：CAMBRIDGE ENTPR LTD

  公开号：WO2008099175A1

  公开（公告）日：2008-08-21

  [EN] The present invention relates to the induction of autophagy via mTOR independent pathways which modulate intracytosolic cAMP levels. In some embodiments, autophagy may be induced in a cell by reducing intracytosolic cAMP levels, for example using a cAMP antagonist, such as clonidine. This may be useful, for example in the treatment of neurodegenerative disorders or pathogen infections.
  [FR] La présente invention concerne l'induction d'autophagie par des trajectoires indépendantes du mTOR qui modulent des niveaux d'AMP cyclique intracytosolique. Dans certains modes de réalisation, l'autophagie peut être induite dans une cellule en réduisant les niveaux d'AMP cyclique intracytosolique, par exemple en utilisant un antagoniste d'AMP cyclique, tel que la clonidine. Cela peut s'avérer utile par exemple dans le traitement de troubles neurodégénératifs ou d'infections pathogènes.