2,4-dihydroxy-6-propylbenzaldehyde | 37455-87-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,4-dihydroxy-6-propylbenzaldehyde
• 英文别名: 2,4-Dihydroxy-6-propylbenzaldehyde
• CAS: 37455-87-1
• 化学式: C₁₀H₁₂O₃
• 分子量: 180.203
• InChiKey: UZIMQJKPLFIOJN-UHFFFAOYSA-N

物化性质

• 沸点：
  336.6±22.0 °C(Predicted)
• 密度：
  1.223±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,4-dihydroxy-6-propylbenzaldehyde 在 4-二甲氨基吡啶 、 sodium chlorite 、 水 、 对甲苯磺酸 、 三乙胺 、 sodium hydroxide 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 二甲基亚砜 、 甲苯 为溶剂， 反应 5.0h， 生成 次大麻二酚
  参考文献：
  名称：

  [EN] METHODS FOR SYNTHESIS OF CANNABINOID COMPOUNDS
  [FR] PROCÉDÉS DE SYNTHÈSE DE COMPOSÉS CANNABINOÏDES

  摘要：

  本发明提供了制备大麻素化合物（如CBD、CBDV、THC、THCV、CBN、HU-308、CBG、CBC以及它们的衍生物）的简单合成途径，这些途径具有立体选择性并且能够高产率地提供所需的大麻素化合物。

  公开号：

  WO2020031179A1
• 作为产物：
  描述：

  氢氰酸 、 5-丙基-1,3-苯二酚 在 乙醚 作用下， 生成 2,4-dihydroxy-6-propylbenzaldehyde
  参考文献：
  名称：

  Asahina; Yosioka, Chemische Berichte, 1937, vol. 70, p. 1823,1825

  摘要：

  DOI：

文献信息

• Fujikawa et al., Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1956, vol. 76, p. 1326
  作者：Fujikawa et al.

  DOI：——

  日期：——
• Effects of cancer and anti-neoplastic treatment on the human testicular function
  作者：A. De Palma、E. Vicari、I. Palermo、R. D’Agata、Aldo E. Calogero

  DOI：10.1007/bf03343795

  日期：2000.11

  Men with testicular neoplasia (TN) and Hodgkin's disease (HD) are those who more frequently require treatment for fertility because these malignancies affect patients during the reproductive age and because the early diagnosis and the improved anti-neoplastic treatments cure most of these patients. Although some of them can father a child spontaneously, assisted reproductive techniques allow fatherhood to patients with severe spermatogenesis impairment and this possibility has raised concern about the long-term consequence of the testicular damage induced by chemo- and/or radiotherapy. This paper reviews the effects of cancer per se and of anti-neoplastic treatments on gonadal function, sperm aneuploidy rate and sperm DNA integrity. A debate is still open as to whether TN or HD per se may impair spermatogenesis. Many studies have shown that this is the case, albeit others have challenged this view. Chemo- and/or radiotherapy affects negatively gonadal function, rendering almost all patients azoospermics. However, spontaneous pregnancies and a high degree of spermatogenesis recovery occur with time. A large body of literature on sperm chromosome complement suggests an increased rate of structural and numerical chromosome abnormalities in patients with cancer during anti-neoplastic treatment. A minority of them has, however, shown that this effect disappears with time. An interesting and relatively new aspect is the study of sperm DNA integrity in patients with TN and HD particularly following chemo- and/or radiotherapy. The scanty information available seems to suggest that these patients have a permanent or at least a long-lasting DNA fragmentation in their spermatozoa. (C) 2000, Editrice Kurtis.
• Asahina; Akagi, Chemische Berichte, 1935, vol. 68, p. 1130,1132
  作者：Asahina、Akagi

  DOI：——

  日期：——
• Hiraiwa, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1940, vol. 60, p. 569,574
  作者：Hiraiwa

  DOI：——

  日期：——
• Fuzikawa; Inoue, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1940, vol. 60, p. 181,182, 183; dtsch. Ref. S. 58
  作者：Fuzikawa、Inoue

  DOI：——

  日期：——