5-[(octyloxy)methyl]-8-quinolinol | 102269-68-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5-[(octyloxy)methyl]-8-quinolinol
• 英文别名: 5-Octyloxymethyl-8-quinolinol；5-(octoxymethyl)quinolin-8-ol
• CAS: 102269-68-1
• 化学式: C₁₈H₂₅NO₂
• 分子量: 287.402
• InChiKey: LIAHOBMFROLCJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  21
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  42.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  聚合甲醛 、 二氮杂18-冠醚-6 、 5-[(octyloxy)methyl]-8-quinolinol 以 1,4-二氧六环 为溶剂， 反应 3.0h， 以91%的产率得到N,N'-bis((5-octyloxymethyl-8-hydroxy-7-quinolinyl)methyl)-1,10-diaza-18-crown-6 ether
  参考文献：
  名称：

  Microwave Assisted Synthesis of a Small Library of SubstitutedN,N′-Bis((8-hydroxy-7-quinolinyl)methyl)-1,10-diaza-18-crown-6 Ethers

  摘要：

  N,N'- Bis-((8-hydroxy-7-quinolinyl)methyl)-1,10-diaza-18-crown-6 ether 1a and its analogue 1c are known as fluorescent sensors of magnesium in living cells. With the aim to investigate the effects of the substitution pattern on the photophysical properties of ligands 1 and their metal complexes, we developed an efficient microwaves enhanced one-pot Mannich reaction to double-armed diaza-crown ligands 1 carrying a variety of substituents. This new protocol is characterized by shorter reaction times, enhanced yields, and improved product purities with respect to the use of conventional conductive heating.

  DOI：

  10.1021/jo101173t
• 作为产物：
  描述：

  辛醇 、 5-(氯甲基)-8-羟基喹啉盐酸盐 在 ammonium hydroxide 作用下， 以 乙醚 、 水 为溶剂， 反应 2.0h， 以82%的产率得到5-[(octyloxy)methyl]-8-quinolinol
  参考文献：
  名称：

  Microwave Assisted Synthesis of a Small Library of SubstitutedN,N′-Bis((8-hydroxy-7-quinolinyl)methyl)-1,10-diaza-18-crown-6 Ethers

  摘要：

  N,N'- Bis-((8-hydroxy-7-quinolinyl)methyl)-1,10-diaza-18-crown-6 ether 1a and its analogue 1c are known as fluorescent sensors of magnesium in living cells. With the aim to investigate the effects of the substitution pattern on the photophysical properties of ligands 1 and their metal complexes, we developed an efficient microwaves enhanced one-pot Mannich reaction to double-armed diaza-crown ligands 1 carrying a variety of substituents. This new protocol is characterized by shorter reaction times, enhanced yields, and improved product purities with respect to the use of conventional conductive heating.

  DOI：

  10.1021/jo101173t

文献信息

• Electroluminescent metal complexes with nucleophilic carbene ligands
  申请人：Ciba Holding Inc.

  公开号：EP2080796A1

  公开（公告）日：2009-07-22

  This invention relates to the use of electroluminescent metal complexes of the formula wherein the ring A, represents an optionally substituted aryl group which can optionally contain heteroatoms, the ring B, represents an optionally substituted nitrogen containing aryl group, which can optionally contain further heteroatoms, or the ring A may be taken with the ring B binding to the ring A to form a ring; the group C, represents an acyclic carbene, or a cyclic carbene (ring C), which can optionally contain heteroatoms, the ring D, represents an optionally substituted aryl group which can optionally contain heteroatoms, n1 is an integer of 1 to 3, m1 is an integer of 0, 1, or 2, m2 is an integer 0, or 1, M1 is a metal with an atomic weight of greater than 40, L3 is a monodentate ligand, or a bidentate ligand, Y is -C(=O)-, or -C(X1)2-, wherein X1 is hydrogen, or C1-4alkyl, especially hydrogen, and y is 0, or 1, especially 0; in electronic devices, especially organic light emitting diodes (OLEDs), as oxygen sensitive indicators, as phosphorescent indicators in bioassays, and as catalysts.

  本发明涉及以下式子的电致发光金属络合物的用途 其中 环 A 代表任选取代的芳基，可任选含有杂原子、 环 B、 代表任选取代的含氮芳基，该芳基可任选含有更多的杂原子，或者环 A 可与环 B 结合在一起形成环；基团 C、 代表无环碳烯或环碳烯（环 C），可选择含有杂原子、 环 D、 代表任选取代的芳基，可任选含有杂原子、 n1 是 1 至 3 的整数，m1 是 0、1 或 2 的整数，m2 是 0 或 1 的整数、 M1 是原子量大于 40 的金属、 L3 是单齿配体或双齿配体、 Y 是-C(=O)-，或-C(X1)2-，其中 X1 是氢或 C1-4 烷基，尤其是氢，以及 y 是 0 或 1，尤其是 0； 在电子设备中，特别是有机发光二极管（OLED）中，作为氧敏感指示剂，在生物检测中作为磷光指示剂，以及作为催化剂。
• POROUS SILICA AND DEODORANT CONTAINING SAME
  申请人：Toyo Seikan Group Holdings, Ltd.

  公开号：EP3326972A1

  公开（公告）日：2018-05-30

  To provide a porous silica which is capable of effectively eliminating odors of methyl mercaptan, hydrogen sulfide, nonenal and the like, said odors being difficult to be eliminated by a silica porous material that contains no metal. A porous silica containing particles that are provided with primary pores, wherein the particles contain a metal containing substance complex having a particle size of 1-100 nm. This porous silica has a specific surface area of 500 m2/g or more.

  提供一种能有效消除甲硫醇、硫化氢、壬醛等气味的多孔二氧化硅，上述气味是不含金属的多孔二氧化硅材料难以消除的。一种多孔二氧化硅，含有初级孔的颗粒，其中颗粒含有粒径为 1-100 纳米的含金属物质复合物。这种多孔二氧化硅的比表面积为 500 m2/g 或更大。
• Porous silica and deodorant comprising the same
  申请人：Toyo Seikan Group Holdings, Ltd.

  公开号：US11090403B2

  公开（公告）日：2021-08-17

  To provide a porous silica which is capable of effectively eliminating odors of methyl mercaptan, hydrogen sulfide, nonenal and the like, said odors being difficult to be eliminated by a silica porous material that contains no metal. A porous silica containing particles that are provided with primary pores, wherein the particles contain a metal containing substance complex having a particle size of 1-100 nm. This porous silica has a specific surface area of 500 m2/g or more.

  提供一种能有效消除甲硫醇、硫化氢、壬醛等气味的多孔二氧化硅，上述气味是不含金属的多孔二氧化硅材料难以消除的。一种多孔二氧化硅，含有初级孔的颗粒，其中颗粒含有粒径为 1-100 纳米的含金属物质复合物。这种多孔二氧化硅的比表面积为 500 m2/g 或更大。
• [EN] PROCEDURE FOR THE SYNTHESIS OF FLUORESCENT PROBES FOR METALS<br/>[FR] PROCÉDÉ DE SYNTHÈSE DE SONDES FLUORESCENTES POUR MÉTAUX
  申请人：UNIV BOLOGNA ALMA MATER

  公开号：WO2011077226A8

  公开（公告）日：2012-05-18
• ELECTROLUMINESCENT METAL COMPLEXES WITH NUCLEOPHILIC CARBENE LIGANDS
  申请人：Ciba Specialty Chemicals Holding Inc.

  公开号：EP1841834A1

  公开（公告）日：2007-10-10