5-(1,3-dioxolan-2-yl)furan-2-yl-(phenyl)methanone | 1276045-89-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-(1,3-dioxolan-2-yl)furan-2-yl-(phenyl)methanone
• 英文别名: [5-(1,3-Dioxolan-2-yl)furan-2-yl]-phenylmethanone；[5-(1,3-dioxolan-2-yl)furan-2-yl]-phenylmethanone
• CAS: 1276045-89-6
• 化学式: C₁₄H₁₂O₄
• 分子量: 244.247
• InChiKey: SVBQOYGUBFLWPY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  48.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  5-(1,3-dioxolan-2-yl)-2-furanylzinc bromide 、 苯甲酰氯 在 copper(l) iodide 、 lithium chloride 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以93%的产率得到5-(1,3-dioxolan-2-yl)furan-2-yl-(phenyl)methanone
  参考文献：
  名称：

  5-(1,3-Dioxolan-2-yl)-2-furanylzinc bromide; direct preparation, and its application for the synthesis of 5-substituted furan derivatives

  摘要：

  5-(1,3-Dioxolan-2-yl)-2-furanylzinc bromide was easily prepared by the direct insertion of active zinc to 2-bromo-5-(1,3-dioxolane)furan under mild conditions. Of interest, the resulting organozinc was successfully coupled with aryl halides and acid chlorides affording the corresponding coupling products in good to excellent yields. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.01.006

文献信息

• 5-(1,3-Dioxolan-2-yl)-2-furanylzinc bromide; direct preparation, and its application for the synthesis of 5-substituted furan derivatives
  作者：Reuben D. Rieke、Seung-Hoi Kim

  DOI：10.1016/j.tetlet.2011.01.006

  日期：2011.3

  5-(1,3-Dioxolan-2-yl)-2-furanylzinc bromide was easily prepared by the direct insertion of active zinc to 2-bromo-5-(1,3-dioxolane)furan under mild conditions. Of interest, the resulting organozinc was successfully coupled with aryl halides and acid chlorides affording the corresponding coupling products in good to excellent yields. (C) 2011 Elsevier Ltd. All rights reserved.