(2S)-1-phenoxy-3-[N-benzyl-[3,3-bis[4-(methoxycarbonyl)phenyl]propyl]amino]-2-propanol | 259798-84-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (2S)-1-phenoxy-3-[N-benzyl-[3,3-bis[4-(methoxycarbonyl)phenyl]propyl]amino]-2-propanol
• 英文别名: methyl 4-[3-[benzyl-[(2S)-2-hydroxy-3-phenoxypropyl]amino]-1-(4-methoxycarbonylphenyl)propyl]benzoate
• CAS: 259798-84-0
• 化学式: C₃₅H₃₇NO₆
• 分子量: 567.682
• InChiKey: AASYUXJEIYLTBL-HKBQPEDESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  42
• 可旋转键数：
  16
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  85.3
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (2S)-1-phenoxy-3-[N-benzyl-[3,3-bis[4-(methoxycarbonyl)phenyl]propyl]amino]-2-propanol 在 sodium hydroxide 作用下， 生成 (2S)-1-phenoxy-3-[3,3-bis(4-carboxyphenyl)propyl]amino-2-propanol
  参考文献：
  名称：

  Aminoalcohol derivatives and their use as beta 3 adrenergic agonists

  摘要：

  该发明涉及由以下式表示的新氨基醇衍生物或其盐：1其中每个符号如规范中定义或其盐，具有肠道选择性交感兴奋剂、抗溃疡、抗胰腺炎、脂解作用、抗尿失禁和抗排尿活性，以及其制备方法、包含相同的药物组合物，以及用于预防和/或治疗规范中指示的疾病的方法，适用于人类或动物。

  公开号：

  US20030181726A1

文献信息

• AMINOALCOHOL DERIVATIVES AND THEIR USE AS BETA 3 ADRENERGIC AGONISTS
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP1107944A1

  公开（公告）日：2001-06-20
• [EN] AMINOALCOHOL DERIVATIVES AND THEIR USE AS BETA 3 ADRENERGIC AGONISTS<br/>[FR] DERIVES D'AMINOALCOOL ET LEUR UTILISATION COMME AGONISTES DU RECEPTEUR BETA-3-ADRENERGIQUE
  申请人：FUJISAWA PHARMACEUTICAL CO

  公开号：WO2000012462A1

  公开（公告）日：2000-03-09

  This invention relates to new aminoalcohol derivatives or salts thereof represented by formula (I) wherein each symbol is as defined in the specification or salts thereof which have β3 adrenergic agonist activity and therefore have gut selective sympathomimetic, anti-ulcerous, anti-pancreatitis, lipolytic, anti-urinary incontinence and anti-pollakiuria activities, to processes for the preparation thereof, to a pharmaceutical composition comprising the same and to a method for the prevention and/or treatment of diseases indicated in the specification to a human being or an animal.
• Aminoalcohol derivatives and their use as beta 3 adrenergic agonists
  申请人：Fujisawa Pharmaceutical Co. Ltd.

  公开号：US20030181726A1

  公开（公告）日：2003-09-25

  This invention relates to new aminoalcohol derivatives or salts thereof represented by the following formula [I]: 1 wherein each symbol is as defined in the specification or salts thereof which have gut selective sympathomimetic, anti-ulcerous, anti-pancreatitis, lipolytic, anti-urinary incontinence and anti-pollakiuria activities, to processes for the preparation thereof, to a pharmaceutical composition comprising the same and to a method for the prevention and/or treatment diseases indicated in the specification to a human being or an animal.

  该发明涉及由以下式表示的新氨基醇衍生物或其盐：1其中每个符号如规范中定义或其盐，具有肠道选择性交感兴奋剂、抗溃疡、抗胰腺炎、脂解作用、抗尿失禁和抗排尿活性，以及其制备方法、包含相同的药物组合物，以及用于预防和/或治疗规范中指示的疾病的方法，适用于人类或动物。