bicyclo[2.2.1]heptane-1,4-diamine | 6600-41-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: bicyclo[2.2.1]heptane-1,4-diamine
• CAS: 6600-41-5
• 化学式: C₇H₁₄N₂
• 分子量: 126.202
• InChiKey: OJPPCWGKNSHPEU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  bicyclo[2.2.1]heptane-1,4-diamine 、 2,5-dichloro-4-(5-(cyclopropylmethyl)-1-methyl-1H-pyrazol-4-yl)pyrimidine 在 N,N-二异丙基乙胺 作用下， 以 二甲基亚砜 为溶剂， 反应 10.0h， 以21%的产率得到N’-(5-chloro-4-(5 -(cyclopropylmethyl)-1-methyl-1H-pyrazol-4-yl)pyrimidin-2-yl)bicyclo[2.2.1]heptane-1,4-diamine
  参考文献：
  名称：

  [EN] HETEROARYL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC USE
  [FR] COMPOSÉS HÉTÉROARYLE, COMPOSITIONS PHARMACEUTIQUES DE CEUX-CI, ET LEUR UTILISATION THÉRAPEUTIQUE

  摘要：

  本文提供了杂环芳基化合物，例如，式I或IA的化合物，以及其药物组成物。本文还提供了它们用于治疗、改善或预防由酪蛋白激酶1（CK1）、白细胞介素-1受体相关激酶（IRAK1）或细胞周期依赖性激酶9（CDK9）介导的一种或多种疾病、疾病或症状的方法。公式：（I），（IA）

  公开号：

  WO2019155468A1

文献信息

• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF RESPIRATORY SYNCYTIAL VIRUS<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR LE TRAITEMENT DU VIRUS RESPIRATOIRE SYNCYTIAL
  申请人：CIDARA THERAPEUTICS INC

  公开号：WO2020252396A1

  公开（公告）日：2020-12-17

  Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral RSV F protein (e.g., Presatovir, MDT 637, JNJ 179, or an analog thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide. In particular, conjugates can be used in the treatment of viral infections (e.g., RSV infections).

  用于治疗病毒感染的组合物和方法包括含有病毒RSV F蛋白抑制剂（例如Presatovir、MDT 637、JNJ 179或其类似物）的共轭物，连接到一个Fc单体、一个Fc结构域和Fc结合肽、一种白蛋白蛋白质或白蛋白结合肽。特别是，这些共轭物可以用于治疗病毒感染（例如RSV感染）。
• HETEROARYL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC USE
  申请人：Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

  公开号：EP3749666A1

  公开（公告）日：2020-12-16
• POLYIMIDE FILMS AND ELECTRONIC DEVICES
  申请人：DUPONT ELECTRONICS, INC.

  公开号：US20210079182A1

  公开（公告）日：2021-03-18

  In a first aspect, a polyimide film includes a dianhydride and a diamine. The dianhydride, the diamine or both the dianhydride and the diamine include an alicyclic monomer, an aliphatic monomer or both an alicyclic monomer and an aliphatic monomer. The polyimide film has a tensile modulus of 5.5 GPa or more, a b* of 1.4 or less and a yellowness index of 2.25 or less for a film thickness of 50 μm. In a second aspect, an electronic device includes the polyimide film of the first aspect.
• COATING SOLUTIONS AND CROSSLINKED POLYMER FILMS
  申请人：DUPONT ELECTRONICS, INC.

  公开号：US20220282118A1

  公开（公告）日：2022-09-08

  In a first aspect, a coating solution includes a soluble polymer and a crosslinking precursor. The soluble polymer includes an imide group. The crosslinking precursor includes a first amine group that is either reactive or passivated towards crosslinking and one or more additional amine groups, wherein the one or more additional amine groups has been passivated towards crosslinking such that the crosslinking precursor can be chemically converted, thermally converted, photo-converted or dissociated to form at least two reactive amines. In a second aspect, a process for forming a polymer film includes: (a) casting a coating solution, (b) activating the crosslinking precursor using an external stimulus to form at least two reactive amines and crosslink the polymer, and (c) drying the polymer film. The coating solution includes a soluble polymer, including an imide group, and a crosslinking precursor.
• US5281675A
  申请人：——

  公开号：US5281675A

  公开（公告）日：1994-01-25