(+)-viridiflorol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (+)-viridiflorol
• 英文别名: Viridiflorol (incomplete stereochemistry)；(1aR,4S,4aS,7R,7aS)-1,1,4,7-tetramethyl-2,3,4a,5,6,7,7a,7b-octahydro-1aH-cyclopropa[e]azulen-4-ol
• 化学式: C₁₅H₂₆O
• 分子量: 222.371
• InChiKey: AYXPYQRXGNDJFU-OMDCQRFSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  trimethyl(((1aR,7R,7aS,7bR)-1,1,7-trimethyl-1a,2,3,5,6,7,7a,7b-octahydro-1H-cyclopropa[e]azulen-4-yl)oxy)silane 在 Oxone 、 lithium aluminium tetrahydride 、 18-冠醚-6 、 碳酸氢钠 、 三乙胺 、 丙酮 作用下， 以 甲醇 为溶剂， 反应 23.0h， 生成 (+)-viridiflorol
  参考文献：
  名称：

  The synthesis of mono- and dihydroxy aromadendrane sesquiterpenes, starting from natural (+)-aromadendrene-III

  摘要：

  The monoalcohols (-)-globulol (2), (-)-epiglobulol (3), (-)-ledol (4), and (+)-viridiflorol (5) were synthesized from (+)-aromadendrene (1). The cis-fused alloaromadendrone (14), the key intermediate used in the synthesis of 4 and 5, was obtained from the trans-fused apoaromadendrone (13) via a selective protonation of the thermodynamic enol trimethylsilylether 15. After hydroxylation of the tertiary C11 of 13 with RuO4, (+)-spathulenol (6), (-)-allospathulenol (7), and the aromadendrane diols 8-11 could be prepared. Compounds 2-11 were tested for antifungal properties, but their activity was only moderate.

  DOI：

  10.1016/s0040-4020(01)88765-2

文献信息

• DETERGENT COMPOSITION FOR THE CONTROL AND REMOVAL OF BIOFILMS
  申请人：Itram Higiene, S.L.

  公开号：EP3505609A1

  公开（公告）日：2019-07-03

  The present invention relates to a detergent composition for the control and removal of biofilms, which have been formed on a surface. The detergent composition comprises a combination of a mannanase and a botanical active ingredient, so that the combined action of both components provides a high efficiency in the elimination of biofilms adhered on surfaces, both in open areas and in closed areas. It also relates to a method for removing the biofilm in which this composition is used, and to the use thereof.

  本发明涉及一种用于控制和清除表面形成的生物膜的洗涤剂组合物。该洗涤剂组合物由一种甘露聚糖酶和一种植物活性成分组合而成，因此这两种成分的共同作用可以高效地消除附着在开放区域和封闭区域表面上的生物膜。它还涉及一种使用这种组合物去除生物膜的方法及其用途。
• Methods for production of oxygenated terpenes
  申请人：Manus Bio, Inc.

  公开号：US10934564B2

  公开（公告）日：2021-03-02

  The present invention relates to methods for producing oxygenated terpenoids. Polynucleotides, derivative enzymes, and host cells for use in such methods are also provided.

  本发明涉及生产含氧萜类化合物的方法。 还提供了用于此类方法的多核苷酸、衍生酶和宿主细胞。
• MALODOR REDUCTION COMPOSITIONS
  申请人：The Procter & Gamble Company

  公开号：EP3197507A1

  公开（公告）日：2017-08-02
• METHOD FOR PRODUCING OXYGENATED VALENCENE
  申请人：Manus Bio Inc.

  公开号：EP3183357B1

  公开（公告）日：2020-03-04
• Volatile Distillate By-Product of Mint Oil That Promotes Absorption and/or Bioavailability of Compounds of Bio-Medical and Nutritional Interest
  申请人：Finley John Westcott

  公开号：US20100197801A1

  公开（公告）日：2010-08-05

  Disclosed is an adjuvant for improving the bioavailability of bioactive compositions. The adjuvant is prepared from a byproduct of mint flavor production. In vitro and in vivo testing confirms effectiveness. The adjuvant contains a mixture of compounds which is effective to improve the oral bioavailability of a bioactive composition normally having limited absorptivity, and it comprises a mixture of nonpolar compounds and compounds with some polar characteristics. In preferred form the nonpolar compounds comprise compounds selected from a group that includes terpene hydrocarbons and terpene derivatives and the compounds with some polar characteristics comprise compounds selected from a group that includes aldehydes, alcohols and ketones. The preferred compositions will have a ratio of nonpolar compounds and compounds with some polar characteristics is within the range of from 5:1 to 20:1. The adjuvants can enhance delivery of CoQ10 and other bioactive compositions, such as carotenoids (e.g., β-carotene), curcuminoids, lycopene, resveratrol, flavonoids and other phenolic compounds, organosulfur compounds, saponins, sterols, stanols, and mixtures of at least two of these, to the interior cellular environment, including organelles, such as the mitochondria.