(methoxymethoxy)cyclohexane | 42604-09-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (methoxymethoxy)cyclohexane
• 英文别名: O-(methoxymethyl)cyclohexanol；formaldehyde-(cyclohexyl-methyl-acetal)；Methoxymethyl-cyclohexyl-aether；Methoxymethoxycyclohexane
• CAS: 42604-09-1
• 化学式: C₈H₁₆O₂
• 分子量: 144.214
• InChiKey: QLPPJSYDXNHJMH-UHFFFAOYSA-N

物化性质

• 沸点：
  61.5-62.5 °C(Press: 15 Torr)
• 密度：
  0.9375 g/cm3(Temp: 16 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (methoxymethoxy)cyclohexane 在 β-环糊精 、 2-碘酰基苯甲酸 作用下， 以 水 、 丙酮 为溶剂， 反应 10.0h， 以89%的产率得到2-环己烯-1-酮
  参考文献：
  名称：

  水中的小β-环糊精/ IBX：高度仿生的一锅式仿制THP / MOM / Ac / Ts醚去保护，并伴随查尔酮环氧化物的氧化裂解和醇的氧化脱氢

  摘要：

  对THP / MOM / Ac / Ts醚进行温和有效的一锅脱保护，并进行环氧化物的氧化裂解和醇的氧化脱氢反应，形成[小β-羟基1，2，2二酮，1,2,3三酮...

  DOI：

  10.1039/c5gc01785h
• 作为产物：
  描述：

  三丁基-[1-(甲氧基甲氧基)环己基]锡烷 在 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 反应 0.03h， 以95%的产率得到(methoxymethoxy)cyclohexane
  参考文献：
  名称：

  Physical properties and synthetic utility of .alpha.-alkoxyorganolithium species as studied through ligand selectivity in tin-lithium exchange

  摘要：

  DOI：

  10.1021/ja00211a024

文献信息

• P4VPy–CuO nanoparticles as a novel and reusable catalyst: application at the protection of alcohols, phenols and amines
  作者：Farhad Shirini、Abdollah Fallah-Shojaei、Masoumeh Abedini、Laleh Samavi

  DOI：10.1007/s13738-016-0887-x

  日期：2016.9

  P4VPy–CuO nanoparticles were synthesized using ultrasound irradiations. Relevant properties of the synthesized nanoparticles were investigated by X-ray diffraction, scanning electron microscopy, transmission electron microscopy and Fourier transform infrared spectroscopy. After identification, the prepared reagent was used for the promotion of different types of protection reactions of alcohols, phenols and amines. Easy workup, short reaction times, excellent yields, relatively low cost and reusability of the catalyst are the striking features of the reported methods.

  采用了超声波辐照法合成了P4VPy–CuO纳米粒子。通过X射线衍射、扫描电子显微镜、透射电子显微镜和傅里叶变换红外光谱对合成的纳米粒子的相关性质进行了研究。在鉴定之后，制备的试剂被用于促进不同类型的醇、酚和胺的保护反应。操作简便、反应时间短、产率高、成本相对较低以及催化剂的重复使用性是所报道方法的显著特点。
• A Facile Preparation of Methoxymethyl Ethers of Primary and Secondary Alcohols with Dimethoxymethane Catalysed by Expansive Graphite
  作者：Tong-Shou Jin、Tong-Shuang Li、Yong-Tao Gao

  DOI：10.1080/00032719808006481

  日期：1998.3.1

  Abstract An easy preparation of methoxymethyl ethers of primary and secondary alcohols with dimethoxymethane has been carried out in excellent yield under catalysis of expansive graphite.

  摘要 在膨胀石墨的催化下，以二甲氧基甲烷简单地制备了伯醇和仲醇的甲氧基甲基醚，收率良好。
• Methods for Producing Fluorine-Containing Hydroxyaldehyde, Fluorine-Containing Propanediol, and Fluorine-Containing Alcohol Monomer
  申请人：Central Glass Company, Limited

  公开号：US20150361026A1

  公开（公告）日：2015-12-17

  As shown by the following reaction formula, disclosed is a fluorine-containing hydroxyaldehyde production method, including the step of obtaining a fluorine-containing hydroxyaldehyde represented by the general formula (1) by reacting a fluorine-containing ketone represented by the general formula (4) and an aldehyde represented by the general formula (5) in the presence of an organic base selected from a heterocyclic compound which contains a nitrogen atom in its ring or a tertiary amine. By this production method, it is possible to obtain the fluorine-containing hydroxyaldehyde in a high yield. Furthermore, it is possible to easily obtain in high yields a fluorine-containing propanediol, which is a derivative of this fluorine-containing hydroxyaldehyde, and a fluorine-containing alcohol monomer by using the same.

  根据以下反应方程式，揭示了一种含氟羟基醛的生产方法，包括通过在选择的含氟酮（通式（4）表示）和醛（通式（5）表示）在含有从含有氮原子的杂环化合物或三级胺中选择的有机碱的情况下反应，获得由通式（1）表示的含氟羟基醛的步骤。通过这种生产方法，可以高产率地获得含氟羟基醛。此外，可以通过使用相同方法轻松高产率地获得含氟丙二醇（这是这种含氟羟基醛的衍生物）和含氟醇单体。
• Electrochemical methoxymethylation of alcohols – a new, green and safe approach for the preparation of MOM ethers and other acetals
  作者：Xiya Luo、Xiaofeng Ma、Frédéric Lebreux、István E. Markó、Kevin Lam

  DOI：10.1039/c8cc05843a

  日期：——

  A new, green, safe, cost-effective and highly efficient electrochemical approach for the methoxymethylation of alcohols and phenols was successfully developed. The methodology was also applied to the synthesis of substituted acetals.

  成功开发了一种新的，绿色的，安全的，具有成本效益的和高效的电化学方法，用于醇和酚的甲氧基甲基化。该方法还用于取代乙缩醛的合成。
• Highly efficient and selective methoxymethylation of alcohols and phenols catalyzed by reusable ZrO(OTf)2 under solvent-free conditions
  作者：Majid Moghadam、Shahram Tangestaninejad、Valiollah Mirkhani、Iraj Mohammadpoor-Baltork、Mostafa Khajehzadeh

  DOI：10.1007/s00706-010-0310-8

  日期：2010.6

  tertiary alcohols were efficiently converted to their corresponding methoxymethyl ethers with formaldehyde dimethyl acetal in the presence of catalytic amounts of ZrO(OTf)2 at room temperature. Phenols were also methoxymethylated by this catalytic system. Advantages of using this catalytic system are the short reaction times, easy catalyst preparation, high product yield, solvent-free conditions, applicability

  摘要在室温下，在催化量的ZrO（OTf）2存在下，用甲醛二甲基乙缩醛将不同的伯醇，仲醇和叔醇有效地转化为其相应的甲氧基甲基醚。酚也通过该催化体系被甲氧基甲基化。使用该催化体系的优点是反应时间短，催化剂制备容易，产物收率高，无溶剂条件，对醇和酚的适用性以及催化剂的可重复使用性。 图形概要