4-acetylphenyl (3,4-dichlorophenyl)carbamate | 85221-17-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-acetylphenyl (3,4-dichlorophenyl)carbamate
• 英文别名: Carbamic acid, (3,4-dichlorophenyl)-, 4-acetylphenyl ester；(4-acetylphenyl) N-(3,4-dichlorophenyl)carbamate
• CAS: 85221-17-6
• 化学式: C₁₅H₁₁Cl₂NO₃
• mdl: MFCD00419435
• 分子量: 324.163
• InChiKey: SVADXMBEHYZPGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-acetylphenyl (3,4-dichlorophenyl)carbamate 以 二甲基亚砜 为溶剂， 生成 N,N-双(3,4-二氯苯基)脲 、 3,4-二氯苯胺 、 对羟基苯乙酮
  参考文献：
  名称：

  [EN] ACTIVATORS OF MYOSIN II FOR MODULATING CELL MECHANICS
  [FR] ACTIVATEURS DE LA MYOSINE II POUR MODULER LA MÉCANIQUE DES CELLULES

  摘要：

  公开号：

  WO2015095202A3
• 作为产物：
  描述：

  3,4-二氯苯异氰酸酯 、 对羟基苯乙酮 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以20%的产率得到4-acetylphenyl (3,4-dichlorophenyl)carbamate
  参考文献：
  名称：

  [EN] ACTIVATORS OF MYOSIN II FOR MODULATING CELL MECHANICS
  [FR] ACTIVATEURS DE LA MYOSINE II POUR MODULER LA MÉCANIQUE DES CELLULES

  摘要：

  公开号：

  WO2015095202A3

文献信息

• Treating and preventing diseases by modulating cell mechanics
  申请人：THE JOHNS HOPKINS UNIVERSITY

  公开号：US10787410B2

  公开（公告）日：2020-09-29

  Described are methods of treating or preventing a disease in a subject treatable by modulating cell mechanics. The method includes administering to a subject having or at risk for such a disease a pharmaceutical composition comprising an agent selected from the group comprising a salt, solvate, or stereoisomer of compound (VIII) or its derivatives or a mixture of their constituents, where the compound has the formula:

  描述了通过调节细胞力学来治疗或预防受试者疾病的方法。该方法包括向患有这种疾病或有这种疾病风险的受试者施用药物组合物，该组合物包含选自化合物(VIII)或其衍生物的盐、溶解物或立体异构体或其成分混合物的组的制剂，其中化合物具有式：
• ACTIVATORS OF MYOSIN II FOR MODULATING CELL MECHANICS
  申请人：THE JOHNS HOPKINS UNIVERSITY

  公开号：US20160311764A1

  公开（公告）日：2016-10-27

  The present invention discloses small molecule compounds as activators of myosin II by promoting its assembly and recruitment to contractile structures in the cell and methods of using such compounds. These compounds are useful to modulate cell and tissue mechanics. This class of molecules, which affect cell mechanics either by activating the contractile system of the cell or modulating cytokinesis, will be used for therapeutic and tissue engineering applications.
• TREATING AND PREVENTING DISEASES BY MODULATING CELL MECHANICS
  申请人：THE JOHNS HOPKINS UNIVERSITY

  公开号：US20200354301A1

  公开（公告）日：2020-11-12

  Described are methods of treating or preventing a disease in a subject treatable by modulating cell mechanics. The method includes administering to a subject having or at risk for such a disease a pharmaceutical composition. comprising an agent selected from the group comprising a salt, solvate, or stereoisomer of compound (VIII) or its derivatives or a mixture of their constituents, where the compound has the formula:
• [EN] ACTIVATORS OF MYOSIN II FOR MODULATING CELL MECHANICS<br/>[FR] ACTIVATEURS DE LA MYOSINE II POUR MODULER LA MÉCANIQUE DES CELLULES
  申请人：UNIV JOHNS HOPKINS

  公开号：WO2015095202A3

  公开（公告）日：2015-08-20