9-(4-nitrostyryl)acridine | 134592-05-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 9-(4-nitrostyryl)acridine
• 英文别名: (E)-9-(4-nitrostyryl)acridine；9-[(E)-2-(4-nitrophenyl)ethenyl]acridine；9-(4-Nitro-styryl)-acridin
• CAS: 134592-05-5
• 化学式: C₂₁H₁₄N₂O₂
• 分子量: 326.354
• InChiKey: TZGCUOSVTVRJON-SDNWHVSQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  58.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  9-(4-nitrostyryl)acridine 在 盐酸 、 tin(ll) chloride 作用下， 生成 9-(p-Amino-styryl)-acridin
  参考文献：
  名称：

  Porai-Koschitz, Chemisches Zentralblatt, 1907, vol. 78, # II, p. 1528

  摘要：

  DOI：
• 作为产物：
  描述：

  9-溴甲基丫啶 在 15-冠醚-5 、 乙醇 、 sodium hydride 作用下， 反应 6.5h， 生成 9-(4-nitrostyryl)acridine
  参考文献：
  名称：

  Bastianelli, Carlo; Caia, Vincenzo; Cum, Giampietro, Journal of the Chemical Society. Perkin transactions II, 1991, # 5, p. 679 - 683

  摘要：

  DOI：

文献信息

• Enzyme substrates, culture media containing same and use thereof in order to detect aminopeptidase activity and/or differentiate gram-positive bacteria from gram-negative bacteria
  申请人：James Arthur

  公开号：US20060035306A1

  公开（公告）日：2006-02-16

  The present invention relates to novel chromogenic substrates which are used to detect aminopeptidase activity in microorganisms or to determine whether at least one bacterium belongs to the Gram-positive group or to the Gram-negative group according to the color thereof. The invention also relates to culture media containing such substrates, to the use of the substrates or media for the detection of aminopeptidase activities and/or the differentiation of Gram-positive bacteria from Gram-negative bacteria and to methods of use. The aforementioned novel substrates have the formula below: in which: R 1 is nothing or an alkyl, allyl or aryl group, R 2 consists of at least one amino acid, preferably alanine, R 3 , R 4 , R 5 and R 6 consist, independently of one another, of H— or —O-alkyl, preferably —O—CH 3 , R 7 consists of H, O—CH 3 , alkyl or halogen, R 8 consists of H or Cl, and n is an integer corresponding to 0 or 1. The invention is particularly suitable for use in the field of diagnostics.

  本发明涉及一种新型的显色底物，用于检测微生物中的氨基肽酶活性，或根据其颜色确定至少一种细菌属于革兰氏阳性群或革兰氏阴性群。该发明还涉及含有这种底物的培养基，以及利用这些底物或培养基检测氨基肽酶活性和/或区分革兰氏阳性细菌和革兰氏阴性细菌的用途和使用方法。 上述新型底物的化学式如下： 其中： R1为无或烷基、烯丙基或芳基， R2由至少一种氨基酸组成，最好是丙氨酸， R3、R4、R5和R6独立地由H-或-O-烷基组成，最好是-O-CH3， R7由H、O-CH3、烷基或卤素组成， R8由H或Cl组成，n是对应于0或1的整数。该发明特别适用于诊断领域。
• Sharp et al., Journal of the Chemical Society, 1943, p. 5
  作者：Sharp et al.

  DOI：——

  日期：——
• Synthesis, spectral characterization, DNA binding ability and anti-cancer screening of new acridine-based derivatives
  作者：Othman M. Salem、Mária Vilková、Jana Janočková、Rastislav Jendželovský、Peter Fedoročko、Ján Imrich、Mária Kožurková

  DOI：10.1007/s00044-017-1931-9

  日期：2017.10

  In this study, a series of newly synthesized acridine derivatives, compounds 4, 6a, and 6b, are described and their biological activity on HL-60 cell lines is assessed using a number of different techniques. Binding studies were also performed between the derivatives and DNA in order to characterize the mechanism of the agents' effect in more detail. The results of ultraviolet-visible absorption spectroscopy prove that the binding of derivatives 4, 6a, and 6b had occurred with a binding constant value of K = 3.5 x 10(4)-4.0 x 10(4) M-1. These findings are indicative of a strong interaction between the derivatives and DNA, and this hypothesis is supported by the results of the fluorescence emission, linear dichroism, and viscometric assays.
• Azami, Mohamed El; Bitit, Najib; Kerbal, Abdelali, Heterocycles, 2001, vol. 55, # 12, p. 2325 - 2340
  作者：Azami, Mohamed El、Bitit, Najib、Kerbal, Abdelali、Lahlou, Souad、Lyazidi, Saadia Ait、Desvergne, Jean-Pierre、Bouas-Laurent, Henri、Bassani, Dario

  DOI：——

  日期：——
• Vlassa, Mircea; Molnariu, Castelia; Silberg, Joan A., Revue Roumaine de Chimie, 1994, vol. 39, # 3, p. 315 - 317
  作者：Vlassa, Mircea、Molnariu, Castelia、Silberg, Joan A.

  DOI：——

  日期：——