2-Furyl 4-bromobutyl ketone | 86607-63-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Furyl 4-bromobutyl ketone
• 英文别名: 5-Bromo-1-(2-furyl)-1-pentanone；5-bromo-1-(furan-2-yl)pentan-1-one
• CAS: 86607-63-8
• 化学式: C₉H₁₁BrO₂
• 分子量: 231.089
• InChiKey: VSAPJUTVEWKWKM-UHFFFAOYSA-N

物化性质

• 熔点：
  54.7 °C
• 沸点：
  311.0±22.0 °C(Predicted)
• 密度：
  1.388±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Furyl 4-bromobutyl ketone 、 丙二酸二甲酯 在 sodium methylate 、 potassium iodide 作用下， 以 甲醇 为溶剂， 反应 2.0h， 生成 dimethyl 2-(furan-2-carbonyl)cyclopentane-1,1-dicarboxylate
  参考文献：
  名称：

  Anodic cyclization of dimethyl 2-(5-aryl-5-oxopentyl)malonates into the corresponding dimethyl 2-aroylcyclopentane-1,1-dicarboxylates

  摘要：

  A wide range of dimethyl 2-(5-aryl-5-oxopentyl)malonates was electrooxidized in methanol, in the presence of catalytic amount of potassium iodide, to give the corresponding dimethyl 2-aroylcyclopentane-1,1-dicarboxylates in high yields.The reactions were carried out under extremely mild reaction conditions, in which the optimal amount of electrolytic current ranged from 2.24 to 2.35 Fmol(-1). The reaction presumably proceeded via a two-electron oxidation process, in which iodide ions played an important role as the electron carrier between the anode and the substrate. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.12.104
• 作为产物：
  描述：

  2-糠醛缩二乙醇 在 盐酸 、 正丁基锂 作用下， 以 四氢呋喃 、 环己烷 、 甲苯 为溶剂， 反应 4.03h， 生成 2-Furyl 4-bromobutyl ketone
  参考文献：
  名称：

  Benzotriazole-Mediated Conversions of Aromatic and Heteroaromatic Aldehydes to Functionalized Ketones

  摘要：

  Aromatic and heteroaromatic aldehydes reacted with benzotriazole and triethyl orthoformate in THF to give the corresponding alpha-(benzotriazol-1-yl)aryl ethyl ethers 7 in good yield. The novel acyl anion precursors 7 underwent smooth lithiation at the methine group followed by trapping with alkyl halides, aldehydes, ketones, and imines to yield the expected substituted intermediates of type 9, which were hydrolyzed under mild conditions without isolation. Benzaldehyde, methyl-, chloro-, and methoxy-substituted benzaldehydes, 1-naphthalenecarboxaldehyde, 2- and 3-furaldehydes, 2- and 3-thiophenecarboxaldehydes, and 2-pyridinecarboxaldehyde were all transformed in this manner into a variety of aryl and heteroaryl ketones with alkyl (10), alpha-hydroxyalkyl (12 and 13), alpha-aminoalkyl (14) and acyl(15) substituents.

  DOI：

  10.1021/jo00128a039

文献信息

• Fayed, S.; Delmas, M.; Gaset, A., Synthetic Communications, 1982, vol. 12, # 14, p. 1121 - 1126
  作者：Fayed, S.、Delmas, M.、Gaset, A.

  DOI：——

  日期：——
• FAYED, S.;DELMAS, M.;GASET, A., SYNTH. COMMUN., 1982, 12, N 14, 1121-1126
  作者：FAYED, S.、DELMAS, M.、GASET, A.

  DOI：——

  日期：——
• Benzotriazole-Mediated Conversions of Aromatic and Heteroaromatic Aldehydes to Functionalized Ketones
  作者：Alan R. Katritzky、Hengyuan Lang、Zuoquan Wang、Zhongxing Zhang、Huimin Song

  DOI：10.1021/jo00128a039

  日期：1995.11

  Aromatic and heteroaromatic aldehydes reacted with benzotriazole and triethyl orthoformate in THF to give the corresponding alpha-(benzotriazol-1-yl)aryl ethyl ethers 7 in good yield. The novel acyl anion precursors 7 underwent smooth lithiation at the methine group followed by trapping with alkyl halides, aldehydes, ketones, and imines to yield the expected substituted intermediates of type 9, which were hydrolyzed under mild conditions without isolation. Benzaldehyde, methyl-, chloro-, and methoxy-substituted benzaldehydes, 1-naphthalenecarboxaldehyde, 2- and 3-furaldehydes, 2- and 3-thiophenecarboxaldehydes, and 2-pyridinecarboxaldehyde were all transformed in this manner into a variety of aryl and heteroaryl ketones with alkyl (10), alpha-hydroxyalkyl (12 and 13), alpha-aminoalkyl (14) and acyl(15) substituents.
• Anodic cyclization of dimethyl 2-(5-aryl-5-oxopentyl)malonates into the corresponding dimethyl 2-aroylcyclopentane-1,1-dicarboxylates
  作者：Mitsuhiro Okimoto、Haruki Yamamori、Masayuki Hoshi、Takashi Yoshida

  DOI：10.1016/j.tetlet.2013.12.104

  日期：2014.2

  A wide range of dimethyl 2-(5-aryl-5-oxopentyl)malonates was electrooxidized in methanol, in the presence of catalytic amount of potassium iodide, to give the corresponding dimethyl 2-aroylcyclopentane-1,1-dicarboxylates in high yields.The reactions were carried out under extremely mild reaction conditions, in which the optimal amount of electrolytic current ranged from 2.24 to 2.35 Fmol(-1). The reaction presumably proceeded via a two-electron oxidation process, in which iodide ions played an important role as the electron carrier between the anode and the substrate. (C) 2014 Elsevier Ltd. All rights reserved.