2-chloro-3-(2,2,2-trifluoroethoxy)pyridine | 256473-04-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-chloro-3-(2,2,2-trifluoroethoxy)pyridine
• 英文别名: 2-Chloro-3-(2,2,2-trifluoro-ethoxy)-pyridine
• CAS: 256473-04-8
• 化学式: C₇H₅ClF₃NO
• 分子量: 211.571
• InChiKey: IUTMJBMTEOTFKB-UHFFFAOYSA-N

物化性质

• 沸点：
  211.0±40.0 °C(Predicted)
• 密度：
  1.396±0.06 g/cm3(Predicted)
• LogP：
  2.2 at 25℃ and pH8.64
• 表面张力：
  51.9mN/m at 1g/L and 20℃

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-chloro-3-(2,2,2-trifluoroethoxy)pyridine 在 硫脲 、 氯 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 5.0h， 以71.2%的产率得到3-(2,2,2-trifluoroethoxy)-2-pyridinesulfonyl chloride
  参考文献：
  名称：

  Zhang, Jianzhong; Xu, Defeng; Wu, Jianping, Asian Journal of Chemistry, 2010, vol. 22, # 1, p. 826 - 828

  摘要：

  DOI：
• 作为产物：
  描述：

  3-氨基-2-氯吡啶 、 2,2,2-三氟乙醇 在 甲烷磺酸 、 溶剂黄146 、 亚硝酸丁酯 作用下， 反应 1.5h， 生成 2-chloro-3-(2,2,2-trifluoroethoxy)pyridine
  参考文献：
  名称：

  Zhang, Jianzhong; Xu, Defeng; Wu, Jianping, Asian Journal of Chemistry, 2010, vol. 22, # 1, p. 826 - 828

  摘要：

  DOI：

文献信息

• CXCR4 chemokine receptor binding comounds
  申请人：——

  公开号：US20040209921A1

  公开（公告）日：2004-10-21

  The present invention relates to compounds that bind to chemokine receptors, and having the formula 1 wherein each A, X, Y, R 1 , R 2 and R 3 are substituents. The present invention also relates to methods of using such compounds, such as in treating HIV infection and inflammatory conditions such as rheumatoid arthritis. Furthermore, the present invention relates to methods to elevate progenitor and stem cell counts, as well as methods to elevate white blood cell counts, using such compounds.

  本发明涉及与趋化因子受体结合的化合物，其具有式1的结构，其中A、X、Y、R1、R2和R3均为取代基。本发明还涉及使用这类化合物的方法，例如在治疗HIV感染和炎症性疾病如类风湿性关节炎中的应用。此外，本发明还涉及使用这类化合物来提高祖细胞和干细胞计数的方法，以及提高白细胞计数的方法。
• 3-substituted pyridine compounds and related synthesis
  申请人：——

  公开号：US20010006805A1

  公开（公告）日：2001-07-05

  The present invention relates to 3-substituted and 2,3-disubstituted pyridine compounds which are useful as intermediates in the synthesis of pyridylsulfonylurea herbicides. The invention also relates to arylation of alcohols using a pyridinediazonium salt. More particularly the arylation process of the instant invention relates to the synthesis of 2,3-disubstituted pyridine compounds via anhydrous diazotization of 3-aminopyridines to form a diazonium salt intermediate that is then reacted with the appropriate alcohol to produce the desired product. The invention additionally relates to pyridine-3-diazonium salt intermediates.

  本发明涉及3-取代和2,3-二取代的吡啶化合物，这些化合物在吡啶磺酰脲除草剂的合成中作为中间体有用。本发明还涉及使用吡啶重氮盐进行醇的芳基化反应。更具体地说，本发明的芳基化过程涉及通过无水重氮化3-氨基吡啶来合成2,3-二取代的吡啶化合物，以形成重氮盐中间体，然后与适当的醇反应以产生所需的产物。本发明还涉及吡啶-3-重氮盐中间体。
• CXCR4 CHEMOKINE RECEPTOR BINDING COMPOUNDS
  申请人：BRIDGER Gary J.

  公开号：US20080255197A1

  公开（公告）日：2008-10-16

  The present invention relates to compounds that bind to chemokine receptors, and having the formula wherein each A, X, Y, R 1 , R 2 and R 3 are substituents. The present invention also relates to methods of using such compounds, such as in treating HIV infection and inflammatory conditions such as rheumatoid arthritis. Furthermore, the present invention relates to methods to elevate progenitor and stem cell counts, as well as methods to elevate white blood cell counts, using such compounds.

  本发明涉及与趋化因子受体结合的化合物，其具有以下式子： 其中每个A、X、Y、R1、R2和R3均为取代基。本发明还涉及使用这种化合物的方法，例如用于治疗HIV感染和炎症性疾病，如类风湿性关节炎。此外，本发明还涉及使用这种化合物提高祖细胞和干细胞数量的方法，以及提高白细胞计数的方法。
• CXCR4 chemokine receptor binding compounds
  申请人：Genzyme Corporation

  公开号：US07291631B2

  公开（公告）日：2007-11-06

  The present invention relates to compounds that bind to chemokine receptors, and having the formula wherein each A, X, Y, R1, R2 and R3 are substituents. The present invention also relates to methods of using such compounds, such as in treating HIV infection and inflammatory conditions such as rheumatoid arthritis. Furthermore, the present invention relates to methods to elevate progenitor and stem cell counts, as well as methods to elevate white blood cell counts, using such compounds.

  本发明涉及结合趋化因子受体的化合物，其具有以下式子： 其中每个A、X、Y、R1、R2和R3均为取代基。本发明还涉及使用这种化合物的方法，例如用于治疗HIV感染和炎症性疾病，如类风湿性关节炎。此外，本发明还涉及使用这种化合物提高祖细胞和干细胞计数的方法，以及提高白细胞计数的方法。
• Diazonium salts which are intermediates for 3-substituted pyridines
  申请人：Syngenta Participations AG

  公开号：US06710180B2

  公开（公告）日：2004-03-23

  The present invention relates to 3-substituted and 2,3-disubstituted pyridine compounds which are useful as intermediates in the synthesis of pyridylsulfonylurea herbicides. The invention also relates to arylation of alcohols using a pyridinediazonium salt. More particularly the arylation process of the instant invention relates to the synthesis of 2,3-disubstituted pyridine compounds via anhydrous diazotization of 3-amninopyridines to form a diazonium salt intermediate that is then reacted with the appropriate alcohol to produce the desired product. The invention additionally relates to pyridine-3-diazonium salt intermediates.

  本发明涉及3-取代和2,3-双取代吡啶化合物，可用作合成吡啶磺酰脲除草剂的中间体。本发明还涉及使用吡啶重氮盐对醇进行芳基化反应。特别是，本发明的芳基化过程涉及通过3-氨基吡啶的无水重氮化形成重氮盐中间体，然后与适当的醇反应，以产生所需的产物的2,3-双取代吡啶化合物的合成。本发明还涉及吡啶-3-重氮盐中间体。