5'-deuterio-adenosine | 57018-86-7

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 5'-deuterio-adenosine
• 英文别名: Adenosin-5'-D；(2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-[deuterio(hydroxy)methyl]oxolane-3,4-diol
• CAS: 57018-86-7；64200-32-4；64200-33-5
• 化学式: C₁₀H₁₃N₅O₄
• 分子量: 268.236
• InChiKey: OIRDTQYFTABQOQ-XQLZWXLASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  140
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  N6-苯甲酰基-2',3'-O-异丙亚基腺苷 在 二氯乙酸 、 硼氘化钠 、 氨 、 溶剂黄146 、 二甲基亚砜 、 N,N'-二环己基碳二亚胺 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 2.0h， 生成 5'-deuterio-adenosine
  参考文献：
  名称：

  Synthesis of²H,¹³C-Labelled 2′-Deoxynucleosides and Their Site Specific Incorporation into Oligo-DNA for Structural Studies via Relaxation Time Measurements

  摘要：

  We have recently shown(1) the usefulness of H-2,C-13-labelled 2'-deoxynucleoside building blocks for structural studies via relaxation time measurements. The synthesis of phosphoramidite blocks 11 and 12 for their site-specific incorporation (indicated by underlines) into the d(5')((1)C(2)G(3)(A) under bar(4)(T) under bar(5)(T) under bar(6)(A) under bar(7)(A) under bar(8)(T) under bar(9)C(10)G)(2)(3') is briefly described for studying the T-1 and T-1 rho relaxations of H-2 and C-13 at specific deuterated carbons in a large molecule.

  DOI：

  10.1080/07328319908044720

文献信息

• Synthesis of deuterated ribo nucleosides N-protected phosphoramidites, and oligonucleotides
  申请人：Srivastava Suresh C.

  公开号：US20140039178A1

  公开（公告）日：2014-02-06

  The present invention is directed towards the synthesis of high purity deuterated sugars, deuterated phosphoramidites, deuterated nucleobases, deuterated nucleosides, deuterated oligonucleotides, and deuterated RNA's of defined sequences which can exhibit biochemically useful and biologically valuable properties, thus having potential for therapeutic uses.

  本发明旨在合成高纯度的氘代糖、氘代磷酰胺、氘代核碱基、氘代核苷、氘代寡核苷酸和具有定义序列的氘代RNA，这些化合物可以展现出生物化学上有用和生物学上有价值的特性，因此具有潜在的治疗用途。
• Nucleoside analogs for treatment of the flaviviridae family of viruses and cancer
  申请人：Cocrystal Pharma, Inc.

  公开号：US10011629B2

  公开（公告）日：2018-07-03

  The present invention is directed to compounds, compositions and methods for treating or preventing Flaviviridae family of viruses (including HCV, Yellow fever, Dengue, Chikungunya and West Nile virus), RSV, HEV, and influenza infection and cancer in human subjects or other animal hosts.

  本发明涉及用于治疗或预防人类或其他动物宿主中黄病毒科病毒（包括 HCV、黄热病、登革热、基孔肯雅病毒和西尼罗河病毒）、RSV、HEV 和流感感染及癌症的化合物、组合物和方法。
• SYNTHESIS OF DEUTERATED RIBO NUCLEOSIDES, N-PROTECTED PHOSPHORAMIDITES, AND OLIGONUCLEOTIDES
  申请人：Ased, LLC

  公开号：EP2882768A2

  公开（公告）日：2015-06-17
• 2',2'-DIHALO NUCLEOSIDE ANALOGS FOR TREATMENT OF THE FLAVIVIRIDAE FAMILY OF VIRUSES AND CANCER
  申请人：Cocrystal Pharma, Inc.

  公开号：EP3212658A1

  公开（公告）日：2017-09-06
• NUCLEOSIDE ANALOGS FOR TREATMENT OF THE FLAVIVIRIDAE FAMILY OF VIRUSES AND CANCER
  申请人：Cocrystal Pharma, Inc.

  公开号：EP3288957A2

  公开（公告）日：2018-03-07