tert-butyl (2-bromo-6-methoxypyridin-3-yl)carbamate | 1338219-50-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: tert-butyl (2-bromo-6-methoxypyridin-3-yl)carbamate
• 英文别名: Tert-butyl (2-bromo-6-methoxypyridin-3-yl)carbamate；tert-butyl N-(2-bromo-6-methoxypyridin-3-yl)carbamate
• CAS: 1338219-50-3
• 化学式: C₁₁H₁₅BrN₂O₃
• 分子量: 303.156
• InChiKey: ALOXPFRSCMRUDW-UHFFFAOYSA-N

物化性质

• 沸点：
  316.7±42.0 °C(Predicted)
• 密度：
  1.430±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  60.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  tert-butyl (2-bromo-6-methoxypyridin-3-yl)carbamate 在 正丁基锂 、 三乙胺 作用下， 以 四氢呋喃 、 正己烷 、 二氯甲烷 为溶剂， 反应 1.17h， 生成 2-{3-[(tert-butoxycarbonyl)amino]-6-methoxypyridin-2-yl}ethyl methanesulfonate
  参考文献：
  名称：

  Preparation of azaindolines and benzoyl substituted azaindolines: precursors of triazabenzo[cd]azulen-9-one PDE4 inhibitors

  摘要：

  The syntheses of various substituted azaindolines are described. Azaindolines were identified as potential key intermediates towards new PDE4 inhibitors. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.08.009
• 作为产物：
  描述：

  5-氨基-2-甲氧基吡啶 在 氢溴酸 、 双氧水 、 sodium hexamethyldisilazane 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 17.0h， 生成 tert-butyl (2-bromo-6-methoxypyridin-3-yl)carbamate
  参考文献：
  名称：

  Preparation of azaindolines and benzoyl substituted azaindolines: precursors of triazabenzo[cd]azulen-9-one PDE4 inhibitors

  摘要：

  The syntheses of various substituted azaindolines are described. Azaindolines were identified as potential key intermediates towards new PDE4 inhibitors. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.08.009

文献信息

• [EN] NITROGEN CONTAINING CONDENSED 2,3-DIHYDROQUINAZOLINONE COMPOUNDS AS NAV1.8 INHIBITORS<br/>[FR] COMPOSÉS DE 2,3-DIHYDROQUINAZOLINONE CONDENSÉS CONTENANT DE L'AZOTE UTILISÉS EN TANT QU'INHIBITEURS DE NAV1.8
  申请人：[en]GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

  公开号：WO2023238065A1

  公开（公告）日：2023-12-14

  Small molecule inhibitors of Nav1.8 voltage-gated sodium ion channel, including compounds of formula (I), (II), (III), (IV), and (V) are described. Also described are pharmaceutical compositions containing a compound of formula (I), (II), (III), (IV), and (V) and uses of the compounds and pharmaceutical compositions for inhibiting Nav1.8 voltage-gated sodium channels and treating Nav1.8 mediated diseases, such as pain and pain-associated diseases and cardiovascular diseases, such as atrial fibrillation.
• Preparation of azaindolines and benzoyl substituted azaindolines: precursors of triazabenzo[cd]azulen-9-one PDE4 inhibitors
  作者：Matthew Badland、Ingrid Devillers、Corinne Durand、Véronique Fasquelle、Bernard Gaudillière、Henry Jacobelli、Ajith C. Manage、Isabelle Pevet、Jocelyne Puaud、Anthony J. Shorter、Roger Wrigglesworth

  DOI：10.1016/j.tetlet.2011.08.009

  日期：2011.10

  The syntheses of various substituted azaindolines are described. Azaindolines were identified as potential key intermediates towards new PDE4 inhibitors. (C) 2011 Elsevier Ltd. All rights reserved.