7-chloro-4-(phenyltellanyl)quinoline | 1415931-43-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-chloro-4-(phenyltellanyl)quinoline
• 英文别名: 4-Phenyltellanyl-7-chloroquinoline；7-chloro-4-phenyltellanylquinoline
• CAS: 1415931-43-9
• 化学式: C₁₅H₁₀ClNTe
• 分子量: 367.304
• InChiKey: RVRPVSYHVHNDPB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.54
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4,7-二氯喹啉 、 联苯二碲 在 potassium hydroxide 作用下， 以 二甲基亚砜 为溶剂， 反应 24.0h， 以90%的产率得到7-chloro-4-(phenyltellanyl)quinoline
  参考文献：
  名称：

  Synthesis and antioxidant properties of novel quinoline–chalcogenium compounds

  摘要：

  Herein we describe our results on the synthesis and antioxidant properties of 4-arylchalcogenyl-7-chloroquinolines. This new class of compounds has been synthesized in high yields by the reaction of 4,7-dichloroquinoline with diaryl dichalcogenides using KOH as base, DMSO as solvent at 100 C under air atmosphere and tolerates a range of substituents in the arylchalcogenyl moiety. The obtained compounds 3a and 3j were screened for in vitro antioxidant activity and the results demonstrated that compound 3j presented a potent antioxidant effect when compared to compound 3a. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.10.067

文献信息

• Synthesis and antioxidant properties of novel quinoline–chalcogenium compounds
  作者：Lucielli Savegnago、Aline I. Vieira、Natália Seus、Bruna S. Goldani、Micheli R. Castro、Eder João Lenardão、Diego Alves

  DOI：10.1016/j.tetlet.2012.10.067

  日期：2013.1

  Herein we describe our results on the synthesis and antioxidant properties of 4-arylchalcogenyl-7-chloroquinolines. This new class of compounds has been synthesized in high yields by the reaction of 4,7-dichloroquinoline with diaryl dichalcogenides using KOH as base, DMSO as solvent at 100 C under air atmosphere and tolerates a range of substituents in the arylchalcogenyl moiety. The obtained compounds 3a and 3j were screened for in vitro antioxidant activity and the results demonstrated that compound 3j presented a potent antioxidant effect when compared to compound 3a. (C) 2012 Elsevier Ltd. All rights reserved.