(5-bromo-2-hydroxyphenyl)(furan-2-yl)methanone | 53877-99-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (5-bromo-2-hydroxyphenyl)(furan-2-yl)methanone
• 英文别名: (5-bromo-2-hydroxyphenyl)furan-2-ylmethanone；(5-bromo-2-hydroxy-phenyl)-[2]furyl ketone；(5-Brom-2-hydroxy-phenyl)-[2]furyl-keton；(5-Bromo-2-hydroxyphenyl)-(furan-2-yl)methanone
• CAS: 53877-99-9
• 化学式: C₁₁H₇BrO₃
• 分子量: 267.079
• InChiKey: AMDRAQCJJXDNOM-UHFFFAOYSA-N

物化性质

• 熔点：
  88-90 °C
• 沸点：
  360.2±32.0 °C(Predicted)
• 密度：
  1.619±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (5-bromo-2-hydroxyphenyl)(furan-2-yl)methanone 在 吡啶 、 氢氧化钾 、 羟胺 作用下， 生成 5-Bromo-3-furan-2-yl-benzo[d]isoxazole
  参考文献：
  名称：

  Thakar; Padhye, Journal of the Indian Chemical Society, 1984, vol. 61, # 8, p. 715 - 716

  摘要：

  DOI：
• 作为产物：
  描述：

  furan-2-carboxylic acid-(4-bromo-phenyl ester) 在 二硫化碳 、 三氯化铝 作用下， 生成 (5-bromo-2-hydroxyphenyl)(furan-2-yl)methanone
  参考文献：
  名称：

  Tiwari; Tripathi, Journal of the Indian Chemical Society, 1954, vol. 31, p. 841,843

  摘要：

  DOI：

文献信息

• Synthesis of photoactive 2-aroyl-3-furylbenzofurans
  作者：K. A. Chudov、K. S. Levchenko、V. N. Yarovenko、M. M. Krayushkin、V. A. Barachevsky、T. K. Baryshnikova、E. P. Grebennikov

  DOI：10.1007/s11172-015-0876-8

  日期：2015.2

  2-Aroyl-3-furylbenzofurans were synthesized by the reaction of α-furoylphenols with α-bromo ketones.

  通过α-呋喃甲酰苯酚与α-溴代酮的反应，合成了2-芳酰基-3-呋喃基苯并呋喃。
• Synthesis and In Vitro Protein Tyrosine Kinase Inhibitory Activity of Furan-2-yl(phenyl)methanone Derivatives
  作者：Fei Lang Zheng、Shu Rong Ban、Xiu E Feng、Cheng Xiao Zhao、Wenhan Lin、Qing Shan Li

  DOI：10.3390/molecules16064897

  日期：——

  A series of novel furan-2-yl(phenyl)methanone derivatives were synthesized, and their structures were established on the basis of 1H-NMR, 13C-NMR and mass spectral data. All the prepared compounds were screened for their in vitro protein tyrosine kinase inhibitory activity and several new derivatives exhibited promising activity, which, in some cases, was identical to, or even better than that of genistein, a positive reference compound. The preliminary structure-activity relationships of these compounds were investigated and are discussed.

  一系列新的呋喃-2-基（苯基）甲酮衍生物被合成，并根据1H-NMR、13C-NMR和质谱数据确定了其结构。所有合成的化合物均进行了体外蛋白酪氨酸激酶抑制活性的筛选，结果显示几种新的衍生物表现出良好的活性， 在某些情况下，其活性与参照化合物贱酰豆素相同，甚至更优。初步的结构-活性关系也进行了研究并进行了讨论。
• Kumari; Krupadanam; Srimannarayana, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2000, vol. 39, # 1, p. 62 - 64
  作者：Kumari、Krupadanam、Srimannarayana

  DOI：——

  日期：——
• One pot synthesis of oxygenated tri-heterocycles as anti-microbial agents
  作者：Imthyaz A. Khan、Manohar V. Kulkarni、Chung-Ming Sun

  DOI：10.1016/j.ejmech.2005.05.007

  日期：2005.11

  A one pot synthesis of an array of angularly linked tri-heterocycles with coumarin, benzofuran and furan rings is described. This high yielding synthesis is achieved by the reaction of various 4-bromomethylcoumarins with furyl o-hydroxyphenyl ketones involving benzylic nucleophilic displacement and intramolecular aldolization. All the compounds have been tested in vitro for their anti-microbial activity against Micrococcus aureus, Pseudomonas chinchori, Asperigillus fumigatus and Penicillium wortmanni at 100, 50, and 25 mu g ml(-1) concentrations. Chloro groups in the benzofuran ring enhanced the activity. (c) 2005 Elsevier SAS. All rights reserved.
• THAKAR, K. A.;PADHYE, A. M., J. INDIAN CHEM. SOC., 1984, 61, N 8, 715-716
  作者：THAKAR, K. A.、PADHYE, A. M.

  DOI：——

  日期：——