3-benzyloxy-4-(2-propenyl)benzyl bromide | 271581-06-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-benzyloxy-4-(2-propenyl)benzyl bromide
• 英文别名: 4-(Bromomethyl)-2-phenylmethoxy-1-prop-2-enylbenzene；4-(bromomethyl)-2-phenylmethoxy-1-prop-2-enylbenzene
• CAS: 271581-06-7
• 化学式: C₁₇H₁₇BrO
• 分子量: 317.225
• InChiKey: KYXOJRCRKCIUGE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-benzyloxy-4-(2-propenyl)benzyl bromide 在 sodium tetrahydroborate 、 重铬酸吡啶 、 正丁基锂 、 偶氮二异丁腈 、 W-2 Raney nickel 、 三正丁基氢锡 、 硫酸二甲酯 作用下， 以 四氢呋喃 、 乙醇 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 57.33h， 生成 (+/-)-trans-2-[3-hydroxy-4-(2-carboxyethyl)benzyl]-3-(3'-hydroxybenzyl)butyrolactone
  参考文献：
  名称：

  Development of a Novel Hapten for Radioimmunoassay of the Lignan, Enterolactone in Plasma (Serum). Total Synthesis of (±)-trans-5-Carboxymethoxyenterolactone and Several Analogues

  摘要：

  A recently developed method for the analysis of the mammalian lignan, enterolactone 1, is based on time-resolved fluoroimmunoassay (TR-FIA) using an europium chelate as a label. This RIA utilizes enterolactone derivatives carrying a carboxylic acid appendage for the production of antiserum and tracer. The synthesis of 5-carboxymethoxyenterolactone 6 and analogues 5, 7 and 8 is described, and their suitability for the method are discussed. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)00078-8
• 作为产物：
  描述：

  3-烯丙氧基-苯甲醛 在 sodium tetrahydroborate 、 potassium tert-butylate 、 三溴化磷 、 N,N-二甲基苯胺 作用下， 以 乙醚 、 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 7.5h， 生成 3-benzyloxy-4-(2-propenyl)benzyl bromide
  参考文献：
  名称：

  Development of a Novel Hapten for Radioimmunoassay of the Lignan, Enterolactone in Plasma (Serum). Total Synthesis of (±)-trans-5-Carboxymethoxyenterolactone and Several Analogues

  摘要：

  A recently developed method for the analysis of the mammalian lignan, enterolactone 1, is based on time-resolved fluoroimmunoassay (TR-FIA) using an europium chelate as a label. This RIA utilizes enterolactone derivatives carrying a carboxylic acid appendage for the production of antiserum and tracer. The synthesis of 5-carboxymethoxyenterolactone 6 and analogues 5, 7 and 8 is described, and their suitability for the method are discussed. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)00078-8

文献信息

• Development of a Novel Hapten for Radioimmunoassay of the Lignan, Enterolactone in Plasma (Serum). Total Synthesis of (±)-trans-5-Carboxymethoxyenterolactone and Several Analogues
  作者：Taru Mäkelä、Jorma Matikainen、Kristiina Wähälä、Tapio Hase

  DOI：10.1016/s0040-4020(00)00078-8

  日期：2000.3

  A recently developed method for the analysis of the mammalian lignan, enterolactone 1, is based on time-resolved fluoroimmunoassay (TR-FIA) using an europium chelate as a label. This RIA utilizes enterolactone derivatives carrying a carboxylic acid appendage for the production of antiserum and tracer. The synthesis of 5-carboxymethoxyenterolactone 6 and analogues 5, 7 and 8 is described, and their suitability for the method are discussed. (C) 2000 Elsevier Science Ltd. All rights reserved.