3-acetyl-1,2,2-trimethyl-cyclopentanecarboxylic acid | 91966-20-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3-acetyl-1,2,2-trimethyl-cyclopentanecarboxylic acid
• 英文别名: 3-Acetyl-1,2,2-trimethyl-cyclopentancarbonsaeure；1.2.2-Trimethyl-3-aethylon-cyclopentan-carbonsaeure-(1)；3-Acetyl-1,2,2-trimethylcyclopentane-1-carboxylic acid
• CAS: 91966-20-0
• 化学式: C₁₁H₁₈O₃
• 分子量: 198.262
• InChiKey: YMMCUWBDKZIFOT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-acetyl-1,2,2-trimethyl-cyclopentanecarboxylic acid 在 乙醇 、 盐酸羟胺 、 水 、 sodium carbonate 作用下， 生成 3-(1-hydroxyimino-ethyl)-1,2,2-trimethyl-cyclopentanecarboxylic acid
  参考文献：
  名称：

  Winzer, Justus Liebigs Annalen der Chemie, 1890, vol. 257, p. 309

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium hydroxide 作用下， 生成 3-acetyl-1,2,2-trimethyl-cyclopentanecarboxylic acid
  参考文献：
  名称：

  Ginnings; Noyes, Journal of the American Chemical Society, 1922, vol. 44, p. 2571

  摘要：

  DOI：

文献信息

• NEW 4-AMINO-4-OXOBUTANOYL PEPTIDES AS INHIBITORS OF VIRAL REPLICATION
  申请人：Phadke Avinash

  公开号：US20140113890A1

  公开（公告）日：2014-04-24

  The invention provides 4-amino-4-oxobutanoyl peptides of Formula I and the pharmaceutically salts and hydrates thereof. The variables R, R 1 , R 6 -R 8 , R 16 , R 18 , R 19 , M, n, T, Y, and Z are defined herein. Certain compounds of Formula I are useful as antiviral agents. The 4-amino-4-oxobutanoyl peptides disclosed herein are potent and/or selective inhibitors of viral replication, particularly Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more 4-amino-4-oxobutanoyl peptides and one or more pharmaceutically acceptable carriers. Such pharmaceutical compositions may contain a 4-amino-4-oxobutanoyl peptides as the only active agent or may contain a combination of a 4-amino-4-oxobutanoyl peptides and one or more other pharmaceutically active agents. The invention also provides methods for treating viral infections, including Hepatitis C infections.
• 4-AMINO-4-OXOBUTANOYL PEPTIDES AS INHIBITORS OF VIRAL REPLICATION
  申请人：ACHILLION PHARMACEUTICALS, INC.

  公开号：US20140328796A1

  公开（公告）日：2014-11-06

  The invention provides 4-amino-4-oxobutanoyl peptide compounds of Formula I and the pharmaceutically salts and hydrates thereof. The variables R 1 -R 9 , R 16 , R 18 , R 19 , n, M, n, M, and Z are defined herein. Certain compounds of Formula I are useful as antiviral agents. Certain 4-amino-4-oxobutanoyl peptide compounds disclosed herein are potent and/or selective inhibitors of viral replication, particularly Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more 4-amino-4-oxobutanoyl peptide compounds and one or more pharmaceutically acceptable carriers. Such pharmaceutical compositions may contain 4-amino-4-oxobutanoyl peptide compound as the only active agent or may contain a combination of 4-amino-4-oxobutanoyl peptide containing peptides compound and one or more other pharmaceutically active agents. The invention also provides methods for treating viral infections, including Hepatitis C infections, in mammals.
• US8785378B2
  申请人：——

  公开号：US8785378B2

  公开（公告）日：2014-07-22
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  公开号：US9133115B2

  公开（公告）日：2015-09-15
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  申请人：——

  公开号：US9233136B2

  公开（公告）日：2016-01-12