4-Nitrocinnamoylamid | 18166-67-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 4-Nitrocinnamoylamid
• 英文别名: 4-nitro-cinnamic acid amide；4-Nitro-zimtsaeure-amid；4-nitro cinnamamide；β-(p-Nitro-phenyl)-acrylamid；3-(4-Nitrophenyl)prop-2-enamide
• CAS: 18166-67-1
• 化学式: C₉H₈N₂O₃
• mdl: MFCD03638186
• 分子量: 192.174
• InChiKey: OAAPPUXSAOJJCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  88.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-Nitrocinnamoylamid 在 sodium hypochlorite 、 硫酸 作用下， 生成 4-硝基苯乙醛
  参考文献：
  名称：

  Weerman, Justus Liebigs Annalen der Chemie, 1913, vol. 401, p. 10

  摘要：

  DOI：
• 作为产物：
  描述：

  对硝基肉桂酸 在 五氯化磷 、 三氯氧磷 作用下， 生成 4-Nitrocinnamoylamid
  参考文献：
  名称：

  Weerman, Justus Liebigs Annalen der Chemie, 1913, vol. 401, p. 10

  摘要：

  DOI：

文献信息

• Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
  申请人：Dow AgroSciences LLC

  公开号：US20170064962A1

  公开（公告）日：2017-03-09

  This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

  这份披露涉及具有对节肢动物门、软体动物门和线虫门害虫有用的杀虫性的分子领域，用于生产这种分子的过程，用于这种过程的中间体，含有这种分子的杀虫组合物，以及使用这种杀虫组合物对这些害虫进行处理的过程。这些杀虫组合物可以用作螨虫剂、杀虫剂、螨虫剂、软体动物杀虫剂和线虫杀虫剂。本文件披露了具有以下式（“式一”）的分子。
• Synthesis of polystyrene-supported Pd(II)-NHC complex derived from theophylline as an efficient and reusable heterogeneous catalyst for the Heck-Matsuda cross-coupling reaction
  作者：Elmira Mohammadi、Barahman Movassagh

  DOI：10.1016/j.molcata.2016.03.045

  日期：2016.7

  morphology of the polymer beads was also studied using scanning electron microscope. The polymer supported Pd(II)-NHC complex exhibits excellent catalytic activity and stability for the Heck-Matsuda cross-coupling reaction under mild conditions. A variety of arenediazonium tetrafluoroborate salts was coupled with the olefinic substrates in ethanol, in the presence of the 0.9 mol% of the catalyst to afford

  摘要 以茶碱为环境友好型NHC前体，采用氯甲基化聚苯乙烯树脂，成功合成了聚苯乙烯负载的钯(II)-N-杂环卡宾配合物PS-NHC-Pd(II)。PS-NHC-Pd(II) 配合物通过多种技术进行表征，包括傅里叶变换红外光谱 (FTIR)、能量色散 X 射线光谱 (EDX)、热分析 (TGA-DTG)、电感耦合等离子体 (ICP) 和CHN元素分析。还使用扫描电子显微镜研究了聚合物珠粒的形态。聚合物负载的 Pd(II)-NHC 配合物在温和条件下对 Heck-Matsuda 交叉偶联反应表现出优异的催化活性和稳定性。多种芳基重氮四氟硼酸盐与乙醇中的烯烃底物偶联，在 0.9 mol% 的催化剂存在下，在空气条件下以高产率提供相应的交叉偶联加合物。此外，多相催化剂可以很容易地通过简单的过滤回收并重复使用七个循环而不会显着降低其活性。
• Heck Arylation of Conjugated Alkenes with Aryl Bromides or Chlorides Catalyzed by Immobilization of Palladium in MCM-41
  作者：Fang Yao、Jiaqin Liu、Mingzhong Cai

  DOI：10.1007/s10562-013-1013-7

  日期：2013.7

  functionalized MCM-41-immobilized palladium(II) complex [MCM-41-2N-PdCl2] was conveniently synthesized from commercially available and cheap 3-(2-aminoethylamino)propyltrimethoxysilane via immobilization on MCM-41, followed by reacting with palladium chloride. It was found that this heterogeneous palladium complex is a highly efficient catalyst for Heck arylation of conjugated alkenes with aryl bromides

  一种新的 3-(2-氨基乙基氨基)丙基功能化 MCM-41 固定化钯 (II) 络合物 [MCM-41-2N-PdCl2] 由市售且廉价的 3-(2-氨基乙基氨基)丙基三甲氧基硅烷通过固定在MCM-41，然后与氯化钯反应。发现这种多相钯配合物是使用四丁基溴化铵作为添加剂对共轭烯烃与芳基溴化物或氯化物进行 Heck 芳基化的高效催化剂，并且可以重复使用至少六次连续试验而不会降低活性。描述了使用 3-(2-氨基乙基氨基)丙基官能化的 MCM-41-固定化钯 (II) 络合物 [MCM-41-2N-PdCl2] 作为有效的多相催化剂，以 TBAB 作为添加剂，使用芳基溴化物或氯化物制备烯烃。
• Use of tetrahydrocarbazone derivatives as 5HT.sub.1 receptor agonists
  申请人：SmithKline Beecham P.L.C.

  公开号：US05464864A1

  公开（公告）日：1995-11-07

  ##STR1## Use of a compound of general formula (I), wherein R.sup.1 represents hydrogen, halogen, trifluoromethyl, nitro, hydroxy, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, arylC.sub.1-6 alkoxy, --CO.sub.2 R.sup.4, --(CH.sub.2).sub.n CN, --(CH.sub.2).sub.n CONR.sup.5 R.sup.6, --(CH.sub.2).sub.n SO.sub.2 NR.sup.5 R.sup.6, C.sub.1-6 alkanoylamino(CH.sub.2).sub.n, or C.sub.1-6 alkylsulphonylamino(CH.sub.2).sub.n ; R.sup.4 represents hydrogen, C.sub.1-6 alkyl or arylC.sub.1-6 alkyl; R.sup.5 and R.sup.6 each independently represent hydrogen or C.sub.1-6 alkyl, or R.sup.5 and R.sup.6 together with the nitrogen atom to which they are attached form a ring; n represents 0, 1 or 2; and R.sup.2 and R.sup.3 each independently represent hydrogen, C.sub.1-6 alkyl; or benzyl or together with the nitrogen atom to which they are attached form a pyrrolidino, piperidino or hexahydroazepino ring; or a physiologically acceptable salt thereof, in the manufacture of a medicament for the treatment of a condition where a 5-HT.sub.1 -like agonist is indicated, for example migraine. Novel compounds of formula (I), processes for preparing them and pharmaceutical compositions containing them are also described.

  在制备治疗5-HT1-样受体激动剂适用的药物时，使用通式（I）的化合物，其中R^1代表氢、卤素、三氟甲基、硝基、羟基、C1-6烷基、C1-6烷氧基、芳基C1-6烷氧基、-CO2R^4、-(CH2)nCN、-(CH2)nCONR^5R^6、-(CH2)nSO2NR^5R^6、C1-6烷酰氨基(CH2)n或C1-6烷基磺酰氨基(CH2)n；R^4代表氢、C1-6烷基或芳基C1-6烷基；R^5和R^6分别独立表示氢或C1-6烷基，或R^5和R^6与其连接的氮原子一起形成环；n代表0、1或2；R^2和R^3分别独立表示氢、C1-6烷基；或苄基，或与其连接的氮原子一起形成吡咯啉、哌啶或六氢脲环；或其生理上可接受的盐，在制备这些化合物和含有它们的药物组合物的过程中也有描述。
• Medicaments 1,2,3,4-tetrahydrocarbazoles and 5-HT.sub.1 agonist use
  申请人：Smithkline Beecham plc

  公开号：US05827871A1

  公开（公告）日：1998-10-27

  Use of a compound of general formula (I): ##STR1## wherein R.sup.1 represents hydrogen, halogen, trifluoromethyl, nitro, hydroxy, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, arylC.sub.1-6 alkoxy, --CO.sub.2 R.sup.4, --(CH.sub.2).sub.n CN, --(CH.sub.2).sub.n CONR.sup.5 R.sup.6, --(CH.sub.2).sub.n SO.sub.2 NR.sup.5 R.sup.6, C.sub.1-6 alkanoylamino(CH.sub.2).sub.n, or C.sub.1-6 alkylsulphonylamino(CH.sub.2).sub.n ; R.sup.4 represents hydrogen, C.sub.1-6 alkyl or arylC.sub.1-6 alkyl; R.sup.5 and R.sup.6 each independently represent hydrogen or C.sub.1-6 alkyl, or R.sup.5 and R.sup.6 together with the nitrogen atom to which they are attached form a ring; n represents 0, 1 or 2; and R.sup.2 and R.sup.3 each independently represent hydrogen, C.sub.1-6 alkyl or benzyl or together with the nitrogen atom to which they are attached form a pyrrolidino, piperidino or hexahydroazepino ring; or a physiologically acceptable salt thereof, in the manufacture of a medicament for the treatment of a condition where a 5-HT.sub.1 -like agonist is indicated, for example migraine. Novel compounds of formula (I), processes for preparing them and pharmaceutical compositions containing them are also described.

  将通用公式(I)的化合物用于制造药物，用于治疗需要5-HT1样受体激动剂的情况，例如偏头痛。公式(I)的新化合物、制备它们的方法以及含有它们的药物组成物也有描述。