5,9,13-Trimethyltetradeca-4,8,12-trienenitrile

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 5,9,13-Trimethyltetradeca-4,8,12-trienenitrile
• 化学式: C₁₇H₂₇N
• 分子量: 245.408
• InChiKey: QVUFWNZNLYZZKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  5,9,13-Trimethyltetradeca-4,8,12-trienenitrile 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 以1.32 g的产率得到
  参考文献：
  名称：

  A Stereoselective Hydroamination Transform To Access Polysubstituted Indolizidines

  摘要：

  Stereoselective, intramolecular, formal hydroamination of dienamines via directed hydroboration is reported. Four stereocenters are set in the process. Natural and unnatural indolizidine alkaloids can be synthesized from simple unsaturated amines using the title process.

  DOI：

  10.1021/ja211090n
• 作为产物：
  描述：

  金合欢醇 在 copper(l) iodide 、 正丁基锂 、 三溴化磷 作用下， 以 四氢呋喃 、 乙醚 、 正己烷 为溶剂， 反应 2.5h， 生成 5,9,13-Trimethyltetradeca-4,8,12-trienenitrile
  参考文献：
  名称：

  A Stereoselective Hydroamination Transform To Access Polysubstituted Indolizidines

  摘要：

  Stereoselective, intramolecular, formal hydroamination of dienamines via directed hydroboration is reported. Four stereocenters are set in the process. Natural and unnatural indolizidine alkaloids can be synthesized from simple unsaturated amines using the title process.

  DOI：

  10.1021/ja211090n

文献信息

• DEVICE AND METHODS FOR DETECTION AND MONITORING OF TUBERCULOSIS
  申请人：Technion Research & Development Foundation Limited

  公开号：EP3602044A1

  公开（公告）日：2020-02-05
• [EN] DEVICE AND METHODS FOR DETECTION AND MONITORING OF TUBERCULOSIS<br/>[FR] DISPOSITIF ET PROCÉDÉS DE DÉTECTION ET DE SURVEILLANCE DE LA TUBERCULOSE
  申请人：TECHNION RES & DEV FOUNDATION

  公开号：WO2018173060A1

  公开（公告）日：2018-09-27

  Methods of diagnosing and/or monitoring tuberculosis (TB) in a subject by analyzing a test sample comprising at least one volatile organic compound (VOC) or semi-volatile organic compound (SVOC) emitted or excreted from the skin of the subject. The test sample can be analyzed by a sensing unit comprising nanomaterials- and/or polymer-based sensors. Further provided is a skin- mountable device comprising a fixing unit and said sensing unit. Also discloses a method of diagnosing and/or monitoring tuberculosis, comprising analyzing specific skin-emitted VOCs or SVOCs, which are indicative of tuberculosis in a subject.