5-嘧啶碳杂氧杂脒,N-2-吡啶基- | 70490-85-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 5-嘧啶碳杂氧杂脒,N-2-吡啶基-
• 中文别名: 1-甲基-4-氨基-2-甲基喹啉鎓
• 英文名称: 4-amino-N,2-dimethylquinolinium iodide
• 英文别名: 4-amino-1,2-dimethyl-quinolinium; iodide；4-Amino-1,2-dimethyl-chinolinium; Jodid；1,2-dimethylquinolin-4(1H)-imine hydroiodide；1,2-dimethylquinolin-4-imine;hydroiodide
• CAS: 70490-85-6
• 化学式: C₁₁H₁₃N₂*I
• 分子量: 300.142
• InChiKey: NIIAVLFMTBTSNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.44
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  29.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-嘧啶碳杂氧杂脒,N-2-吡啶基- 、 N,N-二甲基-4-亚硝基苯胺 生成 2-[(4-dimethylamino-phenylimino)-methyl]-4-imino-1-methyl-1,4-dihydro-quinoline; hydriodide
  参考文献：
  名称：

  Ashley et al., Proceedings of the Royal Society of London, Series B: Biological Sciences, 1933, vol. 113, p. 293,298

  摘要：

  DOI：
• 作为产物：
  描述：

  4-氨基喹哪啶 、 硫酸二甲酯 在 硝基苯 作用下， 生成 5-嘧啶碳杂氧杂脒,N-2-吡啶基-
  参考文献：
  名称：

  Ashley et al., Proceedings of the Royal Society of London, Series B: Biological Sciences, 1933, vol. 113, p. 293,296

  摘要：

  DOI：

文献信息

• PROCESS FOR PRODUCING CARBOXYLIC ACID ANHYDRIDES
  申请人：Tu Ching Liang

  公开号：US20100145098A1

  公开（公告）日：2010-06-10

  A process for producing carboxylic acid anhydrides by the carbonylation reaction of a carboxylic acid ester, derived from an alcohol and a carboxylic acid, with carbon monoxide containing a small amount of hydrogen in a liquid reaction medium in the presence of a Group VIII B catalyst to produce a carboxylic acid anhydride. The reaction medium comprises the Group VIII B catalyst, an organic halide, the carboxylic acid ester, an alkali metal salt, the carboxylic acid anhydride, the carboxylic acid, and at least one ionic liquid consisting of a cation and an anion where the cation of the ionic liquid has a nitrogen-containing heterocyclic structure. The ionic liquid has at least one of the following structural forms: The reaction rate of the carbonylation reaction is increased by the use of the specified ionic liquid promoters.

  一种通过羧酸酯的羰基化反应制备羧酸酐的方法，该羧酸酯由醇和羧酸衍生而来，与含有少量氢气的一氧化碳在液态反应介质中，在第VIII B族催化剂的存在下，产生羧酸酐。反应介质包括第VIII B族催化剂、有机卤素、羧酸酯、碱金属盐、羧酸酐、羧酸和至少一种离子液体，该离子液体由一个阳离子和一个阴离子组成，其中离子液体的阳离子具有含氮杂环结构。离子液体至少具有以下结构形式：使用指定的离子液体促进剂可增加羰基化反应的反应速率。
• Novel Conjugated Quinoline–Indoles Compromise Plasmodium falciparum Mitochondrial Function and Show Promising Antimalarial Activity
  作者：Silvia C. Teguh、Nectarios Klonis、Sandra Duffy、Leonardo Lucantoni、Vicky M. Avery、Craig A. Hutton、Jonathan B. Baell、Leann Tilley

  DOI：10.1021/jm400656s

  日期：2013.8.8

  A novel class of antimalarial compounds, based on an indol-3-yl linked to the 2-position of a 4-aminoquinoline moiety, shows promising activity against the malaria parasite, Plasmodium falciparum. Compounds with a quaternary nitrogen on the quinoline show improved activity against the chloroquine-resistant K1 strain. Nonquaternerized 4-amino-quinolines retain significant potency but are relatively less active against the K1 strain. Alkylation of the 4-amino group preferentially improves the activity against the chloroquine-sensitive 3D7 strain. The quinoline-indoles show only weak activity as inhibitors of beta-hematin formation, and their activities are only weakly antagonized by a hemoglobinase inhibitor. The compounds appear to dissipate mitochondrial potential as an early event in their antimalarial action and therefore may exert their activity by compromising Plasmodium mitochondrial function. Interestingly, we observed a structural relationship between our compounds and the anticancer and anthelminthic compound, pyrvinium pamoate, which has also been proposed to exert its action via compromising mitochondrial function.
• Ashley et al., Proceedings of the Royal Society of London. Series B, Biological sciences, 1933, vol. 113, p. 293,298
  作者：Ashley et al.

  DOI：——

  日期：——
• MIZUYAMA K.; TOMINAGA Y.; MATSUDA Y.; KOBAYASHI G., CHEM. AND PHARM. BULL., 1979, 27, NO 12, 2879-2889
  作者：MIZUYAMA K.、 TOMINAGA Y.、 MATSUDA Y.、 KOBAYASHI G.

  DOI：——

  日期：——
• US8097756B2
  申请人：——

  公开号：US8097756B2

  公开（公告）日：2012-01-17