(E)-3-(4-fluorophenyl)-1-(4-methyl-2-(methylamino)thiazol-5-yl)prop-2-en-1-one | 1350802-15-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-3-(4-fluorophenyl)-1-(4-methyl-2-(methylamino)thiazol-5-yl)prop-2-en-1-one
• 英文别名: (E)-3-(4-fluorophenyl)-1-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]prop-2-en-1-one
• CAS: 1350802-15-1
• 化学式: C₁₄H₁₃FN₂OS
• 分子量: 276.334
• InChiKey: XQOQSIRCTSOXLE-VMPITWQZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  70.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-氯-2,4-戊二酮 在 sodium hydroxide 作用下， 以 甲醇 、 水 、 丙酮 为溶剂， 反应 1.5h， 生成 (E)-3-(4-fluorophenyl)-1-(4-methyl-2-(methylamino)thiazol-5-yl)prop-2-en-1-one
  参考文献：
  名称：

  Novel (E)-1-(4-methyl-2-(alkylamino)thiazol-5-yl)-3-arylprop-2-en-1-ones as potent antimicrobial agents

  摘要：

  New (E)-1-(4-methyl-2-(alkylamino)thiazol-5-yl)-3-arylprop-2-en-1-ones, unsubstituted or carrying fluoro, bromo, methoxy, nitro, methyl and chloro groups on the benzene ring, were synthesized and assayed in vitro for their antimicrobial activity against Gram positive and Gram negative bacteria and fungi. The compounds were very potent towards all tested microorganisms and in most cases their activity was better than that of reference drugs. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.10.059

文献信息

• Novel (E)-1-(4-methyl-2-(alkylamino)thiazol-5-yl)-3-arylprop-2-en-1-ones as potent antimicrobial agents
  作者：K. Liaras、A. Geronikaki、J. Glamočlija、A. Ćirić、M. Soković

  DOI：10.1016/j.bmc.2011.10.059

  日期：2011.12

  New (E)-1-(4-methyl-2-(alkylamino)thiazol-5-yl)-3-arylprop-2-en-1-ones, unsubstituted or carrying fluoro, bromo, methoxy, nitro, methyl and chloro groups on the benzene ring, were synthesized and assayed in vitro for their antimicrobial activity against Gram positive and Gram negative bacteria and fungi. The compounds were very potent towards all tested microorganisms and in most cases their activity was better than that of reference drugs. (C) 2011 Elsevier Ltd. All rights reserved.