Methyl-6α-brom-7-oxo-O-methyl-podocarpat | 1045-54-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Methyl-6α-brom-7-oxo-O-methyl-podocarpat
• 英文别名: Methyl 6alpha-bromo-7-oxo-O-methylpodocarpate；methyl (1S,4aS,10R)-10-bromo-6-methoxy-1,4a-dimethyl-9-oxo-3,4,10,10a-tetrahydro-2H-phenanthrene-1-carboxylate
• CAS: 1045-54-1；10060-22-7；37931-64-9；100174-01-4；127380-56-7
• 化学式: C₁₉H₂₃BrO₄
• 分子量: 395.293
• InChiKey: VXNUYSOLTINORZ-GEPVWJNCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• MODULATORS OF ALPHA-DICARBONYL DETOXIFICATION AND THEIR USE FOR THE TREATMENT OF DIABETIC PATHOLOGIES
  申请人：Buck Institute for Research on Aging

  公开号：US20180015051A1

  公开（公告）日：2018-01-18

  In various embodiments compositions and methods are provided for ameliorating a pathology characterized by elevated α-dicarbonyl compounds or prophylactically slowing or stopping the onset of said pathology in a mammal. In certain embodiments the method comprises administering to the mammal an agent that activates TRPA1 in an amount sufficient to activate TRPA1, and/or to ameliorate one or more symptoms of the pathology (e.g., diabetes or a complication thereof), and/or to slow or stop the onset of the pathology, and/or to lower the level of α-dicarbonyl compounds in the mammal.