1,8-Dimethyl-6,7,8,9-tetrahydronaphtho[1,2-g][1]benzofuran-10,11-dione | 1356254-37-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 1,8-Dimethyl-6,7,8,9-tetrahydronaphtho[1,2-g][1]benzofuran-10,11-dione
• CAS: 1356254-37-9
• 化学式: C₁₈H₁₆O₃
• 分子量: 280.323
• InChiKey: WGZSNPJOTXZUBC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  47.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-甲基-5-羟基苯并呋喃 在 potassium nitrososulfonate 作用下， 以 甲醇 为溶剂， 反应 16.0h， 生成 1,8-Dimethyl-6,7,8,9-tetrahydronaphtho[1,2-g][1]benzofuran-10,11-dione
  参考文献：
  名称：

  Antiandrogenic, Maspin Induction, and Antiprostate Cancer Activities of Tanshinone IIA and Its Novel Derivatives with Modification in Ring A

  摘要：

  Expression of metastatic suppressor maspin is lost in advanced prostate cancer. Clinically relevant mutations in androgen receptor (AR) convert antiandrogens into AR agonists, promoting prostate tumor growth. We discovered tanshinone IIA (TS-IIA) is a potent antagonist of mutated ARs and induces maspin expression through AR. TS-IIA suppressed AR expression and induced apoptosis in LNCaP cells. Syntheses of TS-IIA derivatives (1-9) revealed that the 4,4-dimethyl group at ring A is important for TS-IIA's antiandrogenic and maspin induction activities.

  DOI：

  10.1021/jm2015292

文献信息

• TASHINONES AND THEIR DERIVATIVES: NOVEL EXCELLENT DRUGS FOR ALZHEIMER DISEASE
  申请人：ZHENG Jie

  公开号：US20160022625A1

  公开（公告）日：2016-01-28

  A method for disaggregating amyloid peptide aggregates the method comprising administering a tanshinone or a tanshinone derivatives to an amyloid peptide aggregate. The method may be useful for disaggregating amyloid peptide aggregates in a patient in need of such treatment, such as patients with Alzheimer's disease.
• [EN] NOVEL TASHINONE DRUGS FOR ALZHEIMER DISEASE<br/>[FR] NOUVEAUX MÉDICAMENTS TASHINONE POUR LA MALADIE D'ALZHEIMER
  申请人：ZHENG JIE

  公开号：WO2014138357A1

  公开（公告）日：2014-09-12

  A method for disaggregating amyloid peptide aggregates the method comprising administering a tanshinone or a tanshinone derivatives to an amyloid peptide aggregate. The method may be useful for disaggregating amyloid peptide aggregates in a patient in need of such treatment, such as patients with Alzheimer's disease.
• Antiandrogenic, Maspin Induction, and Antiprostate Cancer Activities of Tanshinone IIA and Its Novel Derivatives with Modification in Ring A
  作者：Weiguo Liu、Jinming Zhou、Guoyan Geng、Qingwen Shi、Francoise Sauriol、Jian Hui Wu

  DOI：10.1021/jm2015292

  日期：2012.1.26

  Expression of metastatic suppressor maspin is lost in advanced prostate cancer. Clinically relevant mutations in androgen receptor (AR) convert antiandrogens into AR agonists, promoting prostate tumor growth. We discovered tanshinone IIA (TS-IIA) is a potent antagonist of mutated ARs and induces maspin expression through AR. TS-IIA suppressed AR expression and induced apoptosis in LNCaP cells. Syntheses of TS-IIA derivatives (1-9) revealed that the 4,4-dimethyl group at ring A is important for TS-IIA's antiandrogenic and maspin induction activities.