胆甾醇基氢琥珀酸盐 | 1510-20-9

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 胆甾醇基氢琥珀酸盐
• 中文别名: 胆固醇琥珀酸酯
• 英文名称: cholesteryl 3-succinate
• 英文别名: cholesteryl hemisuccinate, tris salt；cholesteryl succinate；dicholesteryl succinate；Bernsteinsaeure-dicholesterylester；Dicholesteryl-succinat；bis[cholest-5-en-3β-yl] succinate；Bis[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] butanedioate
• CAS: 1510-20-9
• 化学式: C₅₈H₉₄O₄
• 分子量: 855.382
• InChiKey: PRGHALIMOGZFFF-NTVQCMJZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  17.9
• 重原子数：
  62
• 可旋转键数：
  17
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  丁二酸酐 、 cholesterol 在 对甲苯磺酸 、 苯 作用下， 生成 胆甾醇基氢琥珀酸盐
  参考文献：
  名称：

  Cataline et al., Journal of the American Pharmaceutical Association (1912), 1944, vol. 33, p. 107

  摘要：

  DOI：

文献信息

• Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery
  申请人：Seo Hyo Min

  公开号：US20050201972A1

  公开（公告）日：2005-09-15

  The present invention relates to an amphiphilic block copolymer of a hydrophilic block and a hydrophobic block with a terminal hydroxyl group wherein the terminal hydroxyl group of the hydrophobic bock is substituted with a tocopherol or cholesterol group. It also relates to polymeric compositions capable of forming stable micelles in an aqueous solution, comprising the amphiphilic block copolymer and a polylactic acid derivative wherein one or more ends of the polylactic acid are covalently bound to at least one carboxyl group.

  本发明涉及一种两性块共聚物，包括亲水性块和疏水性块，其末端羟基团与生育酚或胆固醇基团取代的疏水性块。还涉及能在水溶液中形成稳定胶束的聚合物组合物，包括该两性块共聚物和聚乳酸衍生物，其中聚乳酸的一个或多个末端与至少一个羧基共价结合。
• [EN] CHOLESTEROL/BILE ACID/BILE ACID DERIVATIVE-MODIFIED THERAPEUTIC ANTI-CANCER DRUGS<br/>[FR] MEDICAMENTS ANTICANCEREUX THERAPEUTIQUES MODIFIES PAR LE CHOLESTEROL/L'ACIDE BILIAIRE/LES DERIVES D'ACIDE BILIAIRE
  申请人：SONUS PHARMA INC

  公开号：WO2005118612A1

  公开（公告）日：2005-12-15

  Cholesterol-modified anti-cancer therapeutic drug compounds, bile-acid-modified anti-cancer therapeutic drug compounds, and bile-acid-derivative-modified anti-cancer therapeutic drug compounds; emulsion, microemulsion, and micelle formulations that include the compounds, methods for administering the compounds and formulations; and methods for treating cancer using the compounds and formulations.

  胆固醇修饰的抗癌治疗药物化合物，胆酸修饰的抗癌治疗药物化合物，以及胆酸衍生物修饰的抗癌治疗药物化合物；包括这些化合物的乳剂、微乳剂和胶束配方，用于给药这些化合物和配方的方法；以及使用这些化合物和配方治疗癌症的方法。
• NOVEL VITAMIN E-BASED AMPHIPATHIC COMPOUND, AND USE THEREOF
  申请人：Industry-University Cooporation Foundation Hanyang University Erica Campus

  公开号：US20200299252A1

  公开（公告）日：2020-09-24

  The present invention relates to a vitamin E-based amphipathic compound, a method for producing same, and a method for extracting, solubilizing, stabilizing, or crystallizing a membrane protein using same. By using a compound according to the present invention, not only is an excellent membrane protein extraction and solubilization effect achieved, but the membrane protein can be stably stored for a long period of time in an aqueous solution, and thus the compound can be utilized in analyzing the function and structure of the membrane protein. Moreover, the vitamin E-based amphipathic compounds exhibited superb properties in the visualization of protein compounds through an electron microscope. Membrane protein structure and function analysis is one of the fields of greatest interest in biology and chemistry today, and since at least half of new drugs currently being developed target membrane proteins, the vitamin E-based amphipathic compounds may be applied to the membrane protein structure research, which is closely related to the development of new drugs.

  本发明涉及一种基于维生素E的两性分子化合物，以及制备该化合物的方法，以及利用该化合物提取、溶解、稳定或结晶膜蛋白的方法。通过使用本发明的化合物，不仅可以实现出色的膜蛋白提取和溶解效果，而且膜蛋白可以在水溶液中稳定存储长时间，因此该化合物可用于分析膜蛋白的功能和结构。此外，基于维生素E的两性分子化合物在通过电子显微镜可视化蛋白化合物方面表现出卓越性能。膜蛋白结构和功能分析是当今生物学和化学领域最感兴趣的领域之一，由于目前至少一半正在开发的新药物针对膜蛋白，因此基于维生素E的两性分子化合物可能被应用于与新药物开发密切相关的膜蛋白结构研究中。
• NOVEL AMPHIPHILIC COMPOUND HAVING DENDRONIC HYDROPHOBIC GROUP AND APPLICATION THEREOF
  申请人：Industry-University Cooperation Foundation Hanyang University Erica Campus

  公开号：US20200247836A1

  公开（公告）日：2020-08-06

  The present invention relates to an amphiphilic compound having a dendronic hydrophobic group, a method for preparing the same, and a method for extraction, solubilization, stabilization, or crystallization of a membrane protein by using the same. The use of the compound according to the present invention leads to an excellent membrane protein solubilization effect and a stable storage of a membrane protein in an aqueous solution for a long time, and thus can be utilized for functional analysis and structural analysis of the membrane protein. Especially, the amphiphilic compound having a dendronic hydrophobic group showed very remarkable characteristics in the visualization of protein composites through an electronic microscope. The membrane protein structural and functional analysis is one of the fields of greatest interest in current biology and chemistry, and more than half of the new drugs that are currently being developed are targeted at membrane proteins, and thus the amphiphilic compound of the present invention can be applied to membrane protein structure studies closely related to the development of new drugs.

  本发明涉及具有树状疏水基团的两性分子化合物，以及制备该化合物的方法，以及利用该化合物进行膜蛋白的提取、溶解、稳定化或结晶化的方法。根据本发明的化合物的使用导致出色的膜蛋白溶解效果，并使膜蛋白在水溶液中稳定存储较长时间，因此可用于膜蛋白的功能分析和结构分析。特别是，具有树状疏水基团的两性分子化合物在电子显微镜下显示出非常显著的蛋白质复合物可视化特征。膜蛋白的结构和功能分析是当前生物学和化学领域最感兴趣的领域之一，目前正在开发的新药物中超过一半是针对膜蛋白的，因此本发明的两性分子化合物可应用于与新药物开发密切相关的膜蛋白结构研究。
• Solubilization and Targeted Delivery of Drugs With Self-Assembling Amphiphilic Polymers
  申请人：Diwan Anil

  公开号：US20100260743A1

  公开（公告）日：2010-10-14

  There are provided amphiphilic biodegradable copolymers comprising a hydrophilic backbone with pendant aliphatic groups as the hydrophobic component. The polymers form nanoscale molecular aggregates in aqueous environments, which have hydrophobic interiors that are capable of solubilizing insoluble organic compounds such as drugs, vitamins, dyes, and imaging agents. The polymers optionally feature reactive functional groups that provide attachment points for antibodies, ligands, and other targeting moieties useful for the targeted delivery of drugs and imaging agents.

  提供的两性可降解共聚物包括具有羟基亲水骨架和作为疏水组分的脂肪族侧链的共聚物。这些聚合物在水性环境中形成纳米级分子聚集体，具有疏水内部，能够溶解不溶于水的有机化合物，如药物、维生素、染料和成像剂。这些聚合物可选择性地具有反应性功能基团，提供与抗体、配体和其他靶向基团的结合点，有助于药物和成像剂的靶向传递。