胆甾醇基蒽-9-羧酸盐 | 2641-40-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 胆甾醇基蒽-9-羧酸盐
• 英文名称: cholesteryl anthracene-9-carboxylate
• 英文别名: Cholesteryl 9-anthracenecarboxylate；[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] anthracene-9-carboxylate
• CAS: 2641-40-9
• 化学式: C₄₂H₅₄O₂
• 分子量: 590.89
• InChiKey: FMGWOPYZVAWWNP-SKWQCYOWSA-N

物化性质

• 熔点：
  196-197 °C(lit.)
• 沸点：
  685.0±34.0 °C(Predicted)
• 密度：
  1.10±0.1 g/cm3(Predicted)
• 溶解度：
  在DMF中可溶

计算性质

• 辛醇/水分配系数(LogP)：
  13.3
• 重原子数：
  44
• 可旋转键数：
  8
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• CONJUGATE FOR RETENTION IN BLOOD AND CANCER TISSUE-SPECIFIC DRUG DELIVERY
  申请人：YAMANOUCHI PHARMACEUTICAL CO. LTD.

  公开号：EP1591450A1

  公开（公告）日：2005-11-02

  The present invention relates to conjugates of a lipid, substrate peptide of an enzyme secreted from the cells of mammals, including humans, and a water-soluble polymer that can be used as colloidal carriers and the like of tissue-specific drug delivery systems, methods of producing these conjugates, peptide-water-soluble polymer conjugates optionally having protective groups that are useful as the intermediates of these conjugates, colloidal carriers made from these conjugates, and tissue-specific drug delivery systems that use these colloidal carriers.

  本发明涉及可用作组织特异性给药系统胶体载体等的脂质、从哺乳动物（包括人类）细胞中分泌的酶的底物肽和水溶性聚合物的共轭物、生产这些共轭物的方法、肽-水溶性聚合物共轭物（可选择具有用作这些共轭物中间体的保护基团）、由这些共轭物制成的胶体载体以及使用这些胶体载体的组织特异性给药系统。
• TRANSPULMONARY LIPOSOME FOR CONTROLLING DRUG ARRIVAL
  申请人：Otsuka Pharmaceutical Co., Ltd.

  公开号：EP2133097A1

  公开（公告）日：2009-12-16

  An object of the present invention is to provide a liposome which is excellent in intrapulmonary delivery controllability of drugs or genes and is suited for pulmonary administration. By modifying the surface of a liposome using a terminal hydrophobized polyvinyl alcohol and/or chitosan, retention of drugs or genes encapsulated in the liposome on the surface of lung tissue and transfer of drugs or genes into lung tissue can be properly modulated, and thus in vivo behavior can be controlled.

  本发明的目的是提供一种脂质体，该脂质体在肺内输送药物或基因方面具有良好的可控性，适合肺部给药。 通过使用末端疏水的聚乙烯醇和/或壳聚糖修饰脂质体的表面，可以适当调节脂质体中包裹的药物或基因在肺组织表面的滞留以及药物或基因向肺组织的转移，从而控制体内行为。
• Transpulmonary liposome for controlling drug arrival
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP2656858A1

  公开（公告）日：2013-10-30

  An object of the present invention is to provide a liposome which is excellent in intrapulmonary delivery controllability of drugs or genes and is suited for pulmonary administration. By modifying the surface of a liposome using chitosan, retention of drugs or genes encapsulated in the liposome on the surface of lung tissue and transfer of drugs or genes into lung tissue can be properly modulated, and thus in vivo behavior can be controlled.

  本发明的目的是提供一种脂质体，该脂质体在肺内输送药物或基因方面具有良好的可控性，适合肺部给药。 通过使用壳聚糖修饰脂质体的表面，可以适当调节脂质体中包裹的药物或基因在肺组织表面的滞留以及药物或基因向肺组织的转移，从而控制体内行为。
• RADIATION DOSIMETRY SOL OR GEL AND RADIATION DOSIMETER COMPRISING SAME AS MATERIAL FOR RADIATION DOSIMETRY
  申请人：Riken

  公开号：EP3686632A1

  公开（公告）日：2020-07-29

  There is provided a radiation dosimetry sol or gel, and a radiation dosimeter containing the sol or the gel as a material for radiation dosimetry. A radiation dosimetry sol or gel characterized by comprising a compound (A) having an excitation light-induced fluorescence property that is changed by a radiolysis product of water; and a silicate salt (B). A radiation dosimetry sol or gel characterized by comprising a compound (A) having an excitation light-induced fluorescence property that is changed by a radiolysis product of water; a silicate salt (B); a water-soluble organic polymer (C) having an organic acid salt structure or an organic acid anion structure; and a dispersant (D) for the silicate salt (B). A radiation dosimeter comprising, as a material for radiation dosimetry, the above-mentioned radiation dosimetry sol or gel.

  提供了一种辐射剂量测定溶胶或凝胶，以及一种含有该溶胶或凝胶作为辐射剂量测定材料的辐射剂量计。 一种辐射剂量测定溶胶或凝胶，其特征在于包含一种化合物 (A)，该化合物具有由水的辐射分解产物改变的激发光诱导荧光特性；以及一种硅酸盐 (B)。 一种辐射剂量计溶胶或凝胶，其特征在于包含一种化合物（A），该化合物具有受水的辐射分解产物影响而改变的激发光诱导荧光特性；一种硅酸盐（B）；一种具有有机酸盐结构或有机酸阴离子结构的水溶性有机聚合物（C）；以及一种用于硅酸盐（B）的分散剂（D）。 一种辐射剂量计，包括作为辐射剂量测定材料的上述辐射剂量测定溶胶或凝胶。
• Radiation dosimetry sol or gel and radiation dosimeter comprising same as material for radiation dosimetry
  申请人：RIKEN

  公开号：US11150358B2

  公开（公告）日：2021-10-19

  A radiation dosimetry sol or gel, and a radiation dosimeter containing the sol or the gel as a material for radiation dosimetry. A radiation dosimetry sol or gel including a compound (A) having an excitation light-induced fluorescence property that is changed by a radiolysis product of water; and a silicate salt (B). A radiation dosimetry sol or gel including a compound (A) having an excitation light-induced fluorescence property that is changed by a radiolysis product of water; a silicate salt (B); a water-soluble organic polymer (C) having an organic acid salt structure or an organic acid anion structure; and a dispersant (D) for the silicate salt (B). A radiation dosimeter including, as a material for radiation dosimetry, the above-mentioned radiation dosimetry sol or gel.

  一种辐射剂量测定溶胶或凝胶，以及一种含有该溶胶或凝胶作为辐射剂量测定材料的辐射剂量计。一种辐射剂量测定溶胶或凝胶，包括一种化合物 (A)，其激发光诱导荧光特性会因水的辐射分解产物而改变；以及一种硅酸盐 (B)。一种辐射剂量测定溶胶或凝胶，包括一种化合物（A），其激发光诱导荧光特性会因水的辐射分解产物而改变；一种硅酸盐（B）；一种水溶性有机聚合物（C），其具有有机酸盐结构或有机酸阴离子结构；以及一种用于硅酸盐（B）的分散剂（D）。一种辐射剂量计，包括作为辐射剂量测定材料的上述辐射剂量测定溶胶或凝胶。