7-[(Z)-5-[(1R,3S)-3-hydroxy-2,2-dimethyl-6-methylidenecyclohexyl]-3-methylpent-2-enoxy]chromen-2-one

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 7-[(Z)-5-[(1R,3S)-3-hydroxy-2,2-dimethyl-6-methylidenecyclohexyl]-3-methylpent-2-enoxy]chromen-2-one
• 化学式: C₂₄H₃₀O₄
• 分子量: 382.5
• InChiKey: XXKXCRGLMFAXTK-KTRRDNADSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  7-allyloxycoumarin 、 3-(5-hydroxy-3-methylpent-3-enyl)-2,2-dimethyl-4-methylenecyclohexanol 在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) 作用下， 以 二氯甲烷 为溶剂， 生成 法尼斯淝醇 B 、 7-[(Z)-5-[(1R,3S)-3-hydroxy-2,2-dimethyl-6-methylidenecyclohexyl]-3-methylpent-2-enoxy]chromen-2-one
  参考文献：
  名称：

  Total synthesis of (±)-elegansidiol, (±)-farnesiferol B, and (±)-farnesiferol D

  摘要：

  The racemic total synthesis of elegansidiol, farnesiferol B, and farnesiferol D has been obtained following a Diels-Alder approach. Gillman addition, cross metathesis reaction are the other key steps involved in the target synthesis. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.04.030

文献信息

• Total synthesis of (±)-elegansidiol, (±)-farnesiferol B, and (±)-farnesiferol D
  作者：Jhillu Singh Yadav、Kamani Satyanarayana、Pamu Sreedhar、Pabbaraja Srihari、Thokhir Basha Shaik、Shasi Vardhan Kalivendi

  DOI：10.1016/j.bmcl.2010.04.030

  日期：2010.6

  The racemic total synthesis of elegansidiol, farnesiferol B, and farnesiferol D has been obtained following a Diels-Alder approach. Gillman addition, cross metathesis reaction are the other key steps involved in the target synthesis. (C) 2010 Elsevier Ltd. All rights reserved.