1-(methoxymethoxy)-2-(methylamino)ethane | 122225-44-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(methoxymethoxy)-2-(methylamino)ethane
• 英文别名: 1-Methylamino-2-methoxymethoxyethane；2-(methoxymethoxy)-N-methylethanamine
• CAS: 122225-44-9
• 化学式: C₅H₁₃NO₂
• 分子量: 119.164
• InChiKey: MZMUICAIGPEULH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  8
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  30.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(methoxymethoxy)-2-(methylamino)ethane 在 palladium on activated charcoal N-甲基吗啉 、 氢气 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 氯甲酸异丁酯 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 21.3h， 生成 (R)-2-Benzyl-N¹-[(S)-1-[(1S,2R)-1-cyclohexylmethyl-2-((S)-3-ethyl-2-oxo-oxazolidin-5-yl)-2-hydroxy-ethylcarbamoyl]-2-(3H-imidazol-4-yl)-ethyl]-N⁴-(2-methoxymethoxy-ethyl)-N⁴-methyl-succinamide
  参考文献：
  名称：

  Water-soluble renin inhibitors: design of a subnanomolar inhibitor with a prolonged duration of action

  摘要：

  Incorporation of nonreactive polar functionalities at the C- and N-termini of renin inhibitors led to the development of a subnanomolar compound (21) with millimolar solubility. This inhibitor demonstrated excellent efficacy and a long duration of action upon intravenous administration to monkeys. While activity was also observed intraduodenally, a comparison of the blood pressure responses indicated low bioavailability. Subsequent experiments in rats showed that, although the compound was absorbed from the gastrointestinal tract, extensive liver extraction severely limited bioavailability.

  DOI：

  10.1021/jm00169a024
• 作为产物：
  描述：

  2-<<(benzyloxy)carbonyl>methylamino>-1-(methoxymethoxy)ethane 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 反应 12.0h， 以84%的产率得到1-(methoxymethoxy)-2-(methylamino)ethane
  参考文献：
  名称：

  Water-soluble renin inhibitors: design of a subnanomolar inhibitor with a prolonged duration of action

  摘要：

  Incorporation of nonreactive polar functionalities at the C- and N-termini of renin inhibitors led to the development of a subnanomolar compound (21) with millimolar solubility. This inhibitor demonstrated excellent efficacy and a long duration of action upon intravenous administration to monkeys. While activity was also observed intraduodenally, a comparison of the blood pressure responses indicated low bioavailability. Subsequent experiments in rats showed that, although the compound was absorbed from the gastrointestinal tract, extensive liver extraction severely limited bioavailability.

  DOI：

  10.1021/jm00169a024

文献信息

• ROSENBERG, SAUL H.;WOODS, KEITH W.;SHAM, HING L.;KLEINERT, HOLLIS D.;MART+, J. MED. CHEM., 33,(1990) N, C. 1962-1969
  作者：ROSENBERG, SAUL H.、WOODS, KEITH W.、SHAM, HING L.、KLEINERT, HOLLIS D.、MART+

  DOI：——

  日期：——
• Water-soluble renin inhibitors: design of a subnanomolar inhibitor with a prolonged duration of action
  作者：Saul H. Rosenberg、Keith W. Woods、Hing L. Sham、Hollis D. Kleinert、Donald L. Martin、Herman Stein、Jerome Cohen、David A. Egan、Barbara Bopp

  DOI：10.1021/jm00169a024

  日期：1990.7

  Incorporation of nonreactive polar functionalities at the C- and N-termini of renin inhibitors led to the development of a subnanomolar compound (21) with millimolar solubility. This inhibitor demonstrated excellent efficacy and a long duration of action upon intravenous administration to monkeys. While activity was also observed intraduodenally, a comparison of the blood pressure responses indicated low bioavailability. Subsequent experiments in rats showed that, although the compound was absorbed from the gastrointestinal tract, extensive liver extraction severely limited bioavailability.