2-(Furan-2-yl)-1-(4-methoxyphenyl)ethanone | 55001-14-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(Furan-2-yl)-1-(4-methoxyphenyl)ethanone
• 英文别名: 2-(furan-2-yl)-1-(4-methoxyphenyl)ethanone
• CAS: 55001-14-4
• 化学式: C₁₃H₁₂O₃
• 分子量: 216.236
• InChiKey: QVCRSABYTNSERM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  39.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(Furan-2-yl)-1-(4-methoxyphenyl)ethanone 在 三乙基硅烷 、 吡啶盐酸盐 、 phenyltrimethylammonium tribromide 、 sodium hydride 、 N,N-二异丙基乙胺 、 三氟乙酸 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Estrogen receptor ligands. Part 3: The SAR of dihydrobenzoxathiin SERMs

  摘要：

  A series of 3-alkyl, 3-cycloalkyl, and 3-heteroaryl dihydrobenzoxathim analogs 1 were prepared and evaluated for estrogen/anti-estrogen activity in both in vitro and in vivo models. In general, the compounds were found to exhibit a high degree of selectivity for ERalpha over ERbeta, but were less potent than the original lead compound la in the inhibition of estradiol-driven uterine proliferation. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.02.084
• 作为产物：
  描述：

  3-(4-甲氧苯基)-3-氧代丙酸乙酯 在 溶剂黄146 、 lithium chloride 、 zinc(II) chloride 作用下， 以 N-甲基吡咯烷酮 为溶剂， 生成 2-(Furan-2-yl)-1-(4-methoxyphenyl)ethanone
  参考文献：
  名称：

  Estrogen receptor ligands. Part 3: The SAR of dihydrobenzoxathiin SERMs

  摘要：

  A series of 3-alkyl, 3-cycloalkyl, and 3-heteroaryl dihydrobenzoxathim analogs 1 were prepared and evaluated for estrogen/anti-estrogen activity in both in vitro and in vivo models. In general, the compounds were found to exhibit a high degree of selectivity for ERalpha over ERbeta, but were less potent than the original lead compound la in the inhibition of estradiol-driven uterine proliferation. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.02.084

文献信息

• Unusual rearrangement of Fischer carbene complexes to ketones
  作者：Malay Nandi、Kashinath M. Sathe、Amitabha Sarkar

  DOI：10.1039/c39920000793

  日期：——

  A thermal rearrangement of aryl arylmethoxy carbene complexes of chromium and tungsten to aryl arylmethyl ketones is described for the first time.

  首次描述了铬和钨的芳基芳基甲氧基炔烃络合物与芳基芳基甲基酮的热重排反应。
• Estrogen receptor ligands. Part 3: The SAR of dihydrobenzoxathiin SERMs
  作者：Helen Y. Chen、Seongkon Kim、Jane Y. Wu、Elizabeth T. Birzin、Wanda Chan、Yi Tien Yang、Johanna Dahllund、Frank DiNinno、Susan P. Rohrer、James M. Schaeffer、Milton L. Hammond

  DOI：10.1016/j.bmcl.2004.02.084

  日期：2004.5

  A series of 3-alkyl, 3-cycloalkyl, and 3-heteroaryl dihydrobenzoxathim analogs 1 were prepared and evaluated for estrogen/anti-estrogen activity in both in vitro and in vivo models. In general, the compounds were found to exhibit a high degree of selectivity for ERalpha over ERbeta, but were less potent than the original lead compound la in the inhibition of estradiol-driven uterine proliferation. (C) 2004 Elsevier Ltd. All rights reserved.