(2E)-2-cyano-3-phenyl-N-(1,3-thiazol-2-yl)prop-2-enamide | 1006694-45-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (2E)-2-cyano-3-phenyl-N-(1,3-thiazol-2-yl)prop-2-enamide
• 英文别名: (E)-2-cyano-3-phenyl-N-(1,3-thiazol-2-yl)prop-2-enamide
• CAS: 1006694-45-6
• 化学式: C₁₃H₉N₃OS
• 分子量: 255.3
• InChiKey: MJIDWXYGAAMSEW-DHZHZOJOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  94
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2E)-2-cyano-3-phenyl-N-(1,3-thiazol-2-yl)prop-2-enamide 、 氯化苄 在 氢氧化钾 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 26.0h， 以87%的产率得到(2E)-N-benzyl-2-cyano-3-phenyl-N-(1,3-thiazol-2-yl)prop-2-enamide
  参考文献：
  名称：

  N-hetaryl-2-cyanoacetamides in the synthesis of substituted (E)-N-hetaryl-2-cyanoacrylamides, (E)-N-alkyl-N-hetaryl-2-cyanoacrylamides, and 6-amino-2-oxo-4-phenyl-1-(pyridin-2-yl)-1,2-dihydropyridine-3,5-dicarbonitriles

  摘要：

  Knoevenagel condensation of N-hetaryl-substituted cyanoacetamides with aldehydes gave the corresponding (E)-N-hetaryl-2-cyanoacrylamides which were converted into (E)-N-alkyl-N-hetaryl-2-cyanoacrylamides and 6-amino-2-oxo-4-phenyl-1-(pyridin-2-yl)-1,2-dihydropyridine-3,5-dicarbonitriles. The structure of (E)-N-(pyridin-2-yl)-2-cyano-3-phenylprop-2-enamide was determined by X-ray analysis.

  DOI：

  10.1134/s1070428007010101
• 作为产物：
  描述：

  2-氰基-N-噻唑-2-乙酰胺 、 苯甲醛 在 哌啶 作用下， 以 乙醇 为溶剂， 反应 24.0h， 以72%的产率得到(2E)-2-cyano-3-phenyl-N-(1,3-thiazol-2-yl)prop-2-enamide
  参考文献：
  名称：

  N-hetaryl-2-cyanoacetamides in the synthesis of substituted (E)-N-hetaryl-2-cyanoacrylamides, (E)-N-alkyl-N-hetaryl-2-cyanoacrylamides, and 6-amino-2-oxo-4-phenyl-1-(pyridin-2-yl)-1,2-dihydropyridine-3,5-dicarbonitriles

  摘要：

  Knoevenagel condensation of N-hetaryl-substituted cyanoacetamides with aldehydes gave the corresponding (E)-N-hetaryl-2-cyanoacrylamides which were converted into (E)-N-alkyl-N-hetaryl-2-cyanoacrylamides and 6-amino-2-oxo-4-phenyl-1-(pyridin-2-yl)-1,2-dihydropyridine-3,5-dicarbonitriles. The structure of (E)-N-(pyridin-2-yl)-2-cyano-3-phenylprop-2-enamide was determined by X-ray analysis.

  DOI：

  10.1134/s1070428007010101

文献信息

• N-hetaryl-2-cyanoacetamides in the synthesis of substituted (E)-N-hetaryl-2-cyanoacrylamides, (E)-N-alkyl-N-hetaryl-2-cyanoacrylamides, and 6-amino-2-oxo-4-phenyl-1-(pyridin-2-yl)-1,2-dihydropyridine-3,5-dicarbonitriles
  作者：I. V. Dyachenko、V. D. Dyachenko、E. B. Rusanov

  DOI：10.1134/s1070428007010101

  日期：2007.1

  Knoevenagel condensation of N-hetaryl-substituted cyanoacetamides with aldehydes gave the corresponding (E)-N-hetaryl-2-cyanoacrylamides which were converted into (E)-N-alkyl-N-hetaryl-2-cyanoacrylamides and 6-amino-2-oxo-4-phenyl-1-(pyridin-2-yl)-1,2-dihydropyridine-3,5-dicarbonitriles. The structure of (E)-N-(pyridin-2-yl)-2-cyano-3-phenylprop-2-enamide was determined by X-ray analysis.